Fluorescence diffuse optical tomography: Synthesis, characterization and imaging of a novel target specific near infra-red contrast agent for breast cancer detection /

Vinay - 1347201.pdf

Title

Fluorescence diffuse optical tomography: Synthesis, characterization and imaging of a novel target specific near infra-red contrast agent for breast cancer detection /

Subject

Electronics and Communication Engineering

Description

A paradigm shift is seen for cancer treatment since many decades in developing safe and efficient techniques to prevent, detect, treat and cure cancer worldwide. However, there is still a long way to stabilize the rate of cancer occurrence. Breast cancer is found to be among the top three cancer types in terms of incidence and fifth in terms of mortality. An estimate of 2.1 million new cases of breast cancer was recorded in the International Agency for Research on Cancer [IARC] Report 2018. Close to a half (43.6%) of all breast cancers were diagnosed within the Asia-Pacific region (approximately 911014 cases), with the greatest number of those occurring in China, Japan and Indonesia. Although the prognosis is relatively favorable, at least in more developed countries, early diagnosis is the lifesaver. Diffuse Optical Tomography (DOT) is one of the emerging diagnostic tools for early detection of breast cancer. It uses near infra-red (NIR) light to probe human soft tissues and is capable of continuous monitoring of the patient. DOT is cheaper, compact and uses non-ionizing radiation unlike its counterparts like CT-Scan, Mammogram and PET scan. The potential of DOT can be enhanced by using a NIR exogenous contrast agents, and the system is known as Fluorescence-DOT (FDOT). Indocyanine Green (ICG) is a popular FDA approved dye available in the market which is explored for cancer detection using FDOT. But, with its non-specific nature, there was a need for a specific and functionally orientated dye to further improve the efficacy of FDOT imaging.

Creator

Pillai, Vinay Jha - 1347201

Publisher

CHRIST (Deemed to be University)

Date

2021

Language

English

Type

PhD

Collection

Citation

Pillai, Vinay Jha - 1347201, “Fluorescence diffuse optical tomography: Synthesis, characterization and imaging of a novel target specific near infra-red contrast agent for breast cancer detection /,” CHRIST (Deemed To Be University) Institutional Repository, accessed January 28, 2023, http://archives.christuniversity.in/items/show/1809.

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