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Recent Advances in Electrochemical Synthesis of Nitriles: A Sustainable Approach
Nitriles unveil widespread applications in pharmaceuticals, agrochemicals, textiles, rubber, polymers, and constitute a significant intermediate in several organic transformations, necessitating the design of simple and environmentally benign pathways for their synthesis. Over the recent years, electro-organic reactions have found widespread attention in developing effective and selective organic synthesis. They possess several advantages: high atom economy, selectivity, minimal waste production, and shorter routes to multistep traditional organic reactions. The development of novel strategies for greener and sustainable electro-organic synthesis of nitriles is therefore commendable. This review focuses on analyzing various methods and strategies used in the electrochemical synthesis of nitriles using phase transfer catalyst, N-oxoammonium salts mediated electrocatalysis, iodine-mediated electrocatalysis, and anodic oxidations of aldoximes. In addition, the recent trends including the synthesis of nitriles via C?H cyanation, domino oxidation, bio electrocatalysis, and metal-ligand cooperative synthesis have been discussed. 2022 Wiley-VCH GmbH. -
ETHICAL CONFLICTS AMONG THE LEADING MEDICAL AND HEALTHCARE LEADERS
Today, the whole world is fighting the COVID-19 pandemic. In these circumstances, medical professionals are being viewed as the frontline warriors who are risking their lives for the sake of helping, caring, and curing these patients. However, in these difficult times, there are few medical professionals and health care providers who are taking advantage of this situation and taking advantage of distressed and distraught patients at will. A conflict between professional and personal ethical values makes them depressed and puzzled. It is tough for them to maintain a good image of their profession and business. The objectives of this study are to review the ethical conflict amid the ongoing Covid pandemic and post-Covid pandemic (vaccination period) in the context of medical professionals and health care providers. The paper is designed based on a literature review. Almost fifty-two research papers, articles, survey reports, and newspapers were studied in the context of ethics in business/profession. After reviewing moral distress is ongoing and post-pandemic period, the researchers have tried to present the medical professionals and health care providers' critical situation to give priority to their professional ethics or personal interest. School of Engineering, Taylor's University -
A critical review of anticancer properties of Withania somnifera (L.) Dunal with respect to the biochemical mechanisms of its phytochemical constituents
Cancer is a leading cause of mortality worldwide, the conventional chemotherapeutic drugs have been known for their toxicity and numerous side effects. A new approach to treat cancer involves phytochemical drugs. In the present review, anti-cancer activity of a class of steroidal lactones called withanolides obtained from Withania somnifera (L.) Dunal is discussed. The commonly studied bioactive compounds namely withaferin-A, withanoside IV, withanoside VI and withanolide-A among others obtained from methanolic and chloroform extract of the leaves and various alcoholic, aqueous and chloroform extract of roots have shown inhibition to various human cancer cell lines including skin, breast, colon, prostate, liver, ovary, cervical and lung. Prominent mechanisms of action include induction of apoptosis by NOS upregulation, ROS production and NBS2 or COX-2 inhibition; cytotoxicity by humoral and cell mediated immune response, activation of p53 and pRB and inhibition of various viral oncoproteins; cell cycle arrest by Cdc2 facilitated mitotic catastrophe, cyclin-D1 down-regulation and inhibition of transcription factors. Cancers are also controlled by inhibition of angiogenesis and metastasis of the tumor cells. In addition to anti-tumorogenic properties, W. somnifera also holds properties that make it a potential adjuvant in integrated cancer therapeutics and in enhancing the effectiveness of ongoing radiation therapy. Surya et al (2021). -
Responsible and sustainable lending by Financial institutions: a literature Review
The subject of the study is to use an extensive literature review to evaluate how academic research on corporate social responsibility (CSR) is developing. The journals and papers in the ISI Web of Science, SCOPUS, and Taylor&Francis databases served as the foundation for this literature review. The purpose of the study is to highlight essential papers, referenced journals importance, and potential future study directions. Determinants that impact the CSR performance of an organization are governance, profitability, firm characteristics, and minimum expenditure. The impact of CSR has been measured using accounting-based market value, risk, excess return on a stock, and moral capital. All the variables are discussed with strongly supported literature and then concluded by giving a framework. The novelty of our study is that it analyses new research trends while concentrating on the CSR research frontiers. The conclusion identifies possible areas for scientists to further develop their expertise, including sustainable and responsible financing and ESG strategy. Sachdeva S., Ramesh L., 2023. -
Risk management of technological accidents triggered by natural-hazards (Natech): A review of relevant indian legislation
The ill-effects of technological sites on the environment have been researched substantially across the world with particular reference to pollution. However, the threats posed by the environment to technological sites have rarely been studied. Such events, where natural forces trigger technological accidents, are called Natech accidents. It has been observed that developed countries are aware of this emerging hazard and they have responded to it by creating various legislative frameworks for managing Natech risk. In contrast, in developing countries, it has not yet received due attention. The present study has been done to understand the Indian perspective of the legal framework for Natech risk reduction. The study revealed that India has an elaborate legislative framework for disaster risk identification and management. Though there is attention to routine disaster risk, the risk from natural forces to the technological sites is rarely considered. Apart from recognizing natural forces as a threat, no specific legislation is available for Natech risk reduction. A developing country like India must manage the risk posed by natural forces to its technological infrastructure. There is a need for specific legislation to manage Natech risk, which will be an initiating force for the state of the art Natech risk management. 2021, World Research Association. All rights reserved. -
Job Satisfaction Among Health-Care Practitioners: A Bibliometric Analysis
Purpose: The study aims to throw light on job satisfaction among health-care practitioners based on the metadata of published literature from Scopus database with the help of bibliometric analysis. Design/methodology/approach: Metadata of 6,998 publications from the Scopus database were extracted. Bibliometric analysis was done with country-based co-authorship analysis, all keywords-based co-occurrence analysis, sources-based citation analysis, cited authors-based co-citation analysis, and term co-occurrence based on text data. Findings: It was found that United States had the highest number of publications at 2,037. The Journal Of Nursing Management had the highest number of publications (332). Term co-occurrence based on text data reveals that job satisfaction, turnover intention, work engagement, compassion fatigue, job stress, organizational commitment, job demand, job performance, workplace violence, job burnout, career satisfaction, safety climate, organizational support, transformational leadership, leadership style, discrimination, workplace bullying, and job strain are the most prominent terms. The paper also highlights the factors affecting job satisfaction of employees in the health-care sector. Conclusion: The paper tries to highlight the publication trends on the job satisfaction among health-care practitioners. Since health care is a primary sector, prosperity of other sectors in the society depends on the job satisfaction level of employees in this sector. 2024 Association for Radiologic & Imaging Nursing -
A review on ethanol tolerance mechanisms in yeast: Current knowledge in biotechnological applications and future directions
Saccharomyces cerevisiae is one of the prominent strains in the brewing and bioethanol industries and has been used for many industrial purposes for ages. Though the organism is an outstanding ethanol producer, the major limiting factor is the stress the organism undergoes during fermentation. One of the significant stresses is the ethanol stress, created by ethanol accumulation in the medium. The ethanol starts to interact with the yeast cell membrane; further, as ethanol concentration increases, it affects a lot of cell organelles. Thereby, cellular activities get disrupted, causing cell death and hence reducing ethanol production. The organism has developed many strategies to overcome this stress by activating the stress response pathway, which regulates many genes involved in modifying the cell membrane cell wall, renaturation of proteins, and altering the metabolism. However, with higher ethanol concentrations, the yeast cells will be unable to tolerate, leading to cell death. Hence, to minimize cell death at higher ethanol concentrations, there is a need to understand the effect of ethanol and its response by the organism; this helps improve the ethanol tolerance of the organism and, thereby, ethanol production. Although many research works are carried out to understand the vital aspect of the tolerance and are reported, very few review papers cover all these points. Hence, this review is designed to include information on all the elements of ethanol tolerance, i.e., ethanol tolerance of different strains of S. cerevisiae, the effect of ethanol on the yeast cells, the mechanism used to tolerate the ethanol, and various techniques developed to improve the ethanol tolerance of the yeast cells. 2024 Elsevier Ltd -
Nitrogen-doped carbonized polymer dots (CPDs) and their optical and antibacterial characteristics: A short review
Substantial advancements in the field of Carbon Dots (CDs) and their derivatives in recent years can be accredited to their tunable properties. Recently Carbonized Polymer Dots (CPDs) are the emerging form in the CDs family, which possesses a typical polymer/Carbon hybrid structure and properties due to its incomplete carbonization. Alteration of various parameters during the synthesis process suggested that the properties of CPDs depend on temperature and pH. It was found that doping of CPDs using nitrogen enhanced its optical properties, thereby being used as biomarkers. CPDs generally hold a strong green and blue emission, while intense red luminescence was observed doping with nitrogen. Photoluminescence Quantum Yield (PLQY) was also found to increase with the increase in doping and temperature. Doped CPDs find several applications, including bio-imaging, LEDs, etc. In this review, we focus on analyzing the increase in efficiency of CPDs with the process of doping considering optical and antibacterial applications. 2021 by the authors. -
A Review of Comprehension and Operation of DC/DC Converters Precisely Voltage Multiplier and Voltage Lift Converters
Converters in power electronics play a significant part in the power conversion of distributed generation and grid-connected systems. This paper gives comprehension analysis and operation of various non-isolated step-up DC/DC converters for renewable energy applications using voltage multiplier or/and voltage lift techniques to attain higher voltage gain. An isolated converter structure mainly comprises a transformer which is associated with high cost, complexity, leakage inductance, losses and EMI problems with the decrease in the efficiency of the converter, hence the operation of several DC/DC converters precisely voltage multiplier and voltage lift converters are discussed with relative simulation results obtained. 2022 Seventh Sense Research Group. -
A conceptual framework for the worklife balance of police officers: a post-COVID-19 perspective
This study has undertaken a comprehensive review of literature from 2019 to 2021, encompassing work/life balance review articles to identify the research gap in the work/life balance area. Employing the PRISMA framework for systematic literature review, the study identified prospective areas for future research on work/life balance and variables associated with work/life balance in the police sector. The articles published between 2013 and 2023 relating to the police force over the past decade were reviewed to frame a conceptual framework for the work/life balance of police officers. Further literature review attests that there is a research gap in the police sector. The primary goal is to identify the area (work/life balance in the police sector) that lacked research and establish a conceptual framework addressing the work/life balance of police officers, even in challenging situations like COVID-19. The articles related to police from 2013 to 2023 were scrutinised through the PRISMA framework to identify variables necessary for constructing the conceptual framework for police officers. This article, set in the post-COVID-19 era, delves into the factors influencing police officers capacity to uphold a healthy worklife balance. By pinpointing those research gaps, the article proposes a conceptual framework designed to help police officers balance their professional and personal lives. Such a framework can aid organisations in formulating effective strategies for employee well-being, facilitating worklife balance even in challenging circumstances, such as those imposed by the COVID-19 pandemic. 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. -
Medicinal Exploitation of Coriandrum sativum L.
Coriandrum sativum L. is a potential herb that is commonly known as coriander or Chinese parsley is being possessed to have various medicinal properties. Almost all the parts of the herb have been examined for its effectiveness in various human diseases such as migraine, hypertension and diabetes specifically. The diseases considered for the current review are migraine, hypertension and diabetes, which are highly prevalent as well as major co-morbidity for other clinical conditions. The extracts of different parts of C. sativum have been identified to have roles in treating and managing migraine, hypertension and diabetes. The genetic inter-relationship of C. sativum with the diseases are also being discussed in this review. The literature surf was done in platforms for the journals life science and medicinal research using the keywords C. sativum, herbal medicine, anti-diabetic, anti-hypertensive, migraine, genetics etc. The results obtained through the clinical trials conducted by various researchers globally were satisfactorily acceptable in treating these diseases along with some other diseases to a certain extent, whereas the genetic studies were insignificant. Henceforth, the current literature review highlights the medicinal exploitation of C. sativum in accordance with the treatment and management of migraine, hypertension and diabetes. 2022 Visagaa Publishing House. -
Authentication of symmetric cryptosystem using anti-aging controller-based true random number generator
In todays digital world, data protection is extremely important. Every companys data is a valuable asset, so its important to ensure that it's secured from outside threats. Information security is not only an effective but also a necessary element to protect data from unauthorized access. The confidentiality of any communication system is strengthening with the help of random number generators along with some analog circuitry. This type of analog models demands more power and area. So analog circuit-based hardware Random Number Generators (RNG) are least preferred over digital RNGs. To improve the security every industry depends on the one-time password (OTP). Which gives the security but generation of the OTP is very easy. Random number generator is used for the generation of OTP. Similarly, hacking such OTP is easier than creating them. This paper introduces the Anti-Aging controller TRNG, a highly stable high-performance random number generator Anti-Aging Cryptographically Secured True Random Number Generator (AACTRNG). Implementation of this work can be done by using TANNER EDA Tools and ModelSim-Altera 6.4a (Quartus-II 9.0) used for the simulation to retrieve random numbers. 2021, King Abdulaziz City for Science and Technology. -
Microbial Polyhydroxyalkanoates (PHAs): A Review on Biosynthesis, Properties, Fermentation Strategies and Its Prospective Applications for Sustainable Future
Exponential increase in the use and disposal of synthetic plastics has raised an alarming concern related to their adverse effect on the environment due to their recalcitrant nature and non biodegradability. Nevertheless, the depletion in the petrochemical sources made it imperative to search for other sustainable alternatives to synthetic plastics. This triggered the attention on biodegradable plastics produced from plants, animals and microbial sources that have excellent material properties like their synthetic counterparts. Polyhydroxyalkanoates (PHAs) are ineluctably promising microbial polyesters that have the competence to supersede traditional oil-based synthetic polymers which causes major disposal issues worldwide. The compostable nature, biocompatibility, thermostability, and resilience of these bio-based polymers make them an acceptable replacement in the global market. Their versatile material properties made them a propitious candidate in packaging, biomedicine, tissue engineering, biofuel production, nanocomposite formation, and other industrial applications. Despite their potential advantages, the commercialization of PHA is hindered majorly due to the high cost associated with their production and extraction. This review work majorly focuses on the production, extraction, applications and fermentation strategies for enhancing PHA production. The review also addresses the production of PHA from extremophiles, challenges associated with PHA production and sustainable substrates for PHA production using various agroindustrial wastes. 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. -
New Horizons in the Synthesis, Properties, and Applications of MXene Quantum Dots
The progress of MXenes, a 2D layered structural material since its discovery in 2011 recently arouses a great deal of attention due to their plethora of applications in a diverse range of fields. Their excellent properties in terms of surface chemistry, optical activity, electrical conductivity, presence of abundant active catalytic sites, tunable band gap structure, ease of surface functionalization, and good biocompatibility make them an ideal candidate. The authors aim to guide the readers through various aspects such as their unique properties, synthesis techniques, and the recent advancements associated with MXene quantum dots (QDs). Herein, this review serves as a one-stop point for prospective researchers to gain a better understanding of the application of MXene QDs in various fields including electrochemical detection, biomedical applications, and energy conversion and storage applications. 2023 The Authors. Advanced Materials Interfaces published by Wiley-VCH GmbH. -
The Renaissance of Ferrocene-Based Electrocatalysts: Properties, Synthesis Strategies, and Applications
The fascinating electrochemical properties of the redox-active compound ferrocene have inspired researchers across the globe to develop ferrocene-based electrocatalysts for a wide variety of applications. Advantages including excellent chemical and thermal stability, solubility in organic solvents, a pair of stable redox states, rapid electron transfer, and nontoxic nature improve its utility in various electrochemical applications. The use of ferrocene-based electrocatalysts enables control over the intrinsic properties and electroactive sites at the surface of the electrode to achieve specific electrochemical activities. Ferrocene and its derivatives can function as a potential redox medium that promotes electron transfer rates, thereby enhancing the reaction kinetics and electrochemical responses of the device. The outstanding electrocatalytic activity of ferrocene-based compounds at lower operating potentials enhances the specificity and sensitivity of reactions and also amplifies the response signals. Owing to their versatile redox chemistry and catalytic activities, ferrocene-based electrocatalysts are widely employed in various energy-related systems, molecular machines, and agricultural, biological, medicinal, and sensing applications. This review highlights the importance of ferrocene-based electrocatalysts, with emphasis on their properties, synthesis strategies for obtaining different ferrocene-based compounds, and their electrochemical applications. 2023, The Author(s), under exclusive licence to Springer Nature Switzerland AG. -
An extensive critique on expert system control in solar photovoltaic dominated microgrids
Solar and wind power have recently become a potential option in power systems and act significantly to meet load penetration demands. The present growth of such renewable energy sources has shown an exponential increase. The high penetration of such system helps a grid effectively meet its load in an irregular demand but also creates some disturbances in the grid due to frequent additions and detachments of load or source. The way by which the renewable energy sources usually work in the on-grid mode is to be attached to and cut down from the grids without creating disturbances in a stable grid. Another important requirement is effective load management with fewer transmission losses. This article presents a detailed review of a microgrid and enumerates the possible methods for the analysis of the system, feature extraction, control methods, and options for machine learning. This paper examines the factors affecting the operations in a power system, their nature, interdependability, and controllability. It also inspects the various machine learning algorithms, their feasibility, and possible applications in power systems. The major contribution of the paper is the elucidation of expert system control methods for the performance improvement of solar PV assisted DC microgrids. The major objective of the paper is to provide an overview on various algorithms intended for the microgrid systems pertaining to its accuracy, precision, classification, prediction and forecasting. 2023 The Authors. IET Renewable Power Generation published by John Wiley & Sons Ltd on behalf of The Institution of Engineering and Technology. -
Usage data for predicting user trends and behavioral analysis in E-commerce applications
Reviewing and buying the right goods from online websites is growing day by day in todays fast internet environment. Numerous goods in the same label are available to consumers. It is thus a difficult job for consumers to pick up the correct commodity at a decent price under different market conditions. Therefore, it is important for owners of online shopping websites to better understand their customers needs and offer better services. For these reasons, the access log documented a vast amount of data related to user interactions with the websites. This access log therefore plays a key role in predicting user access trends and in recommending the best product to consumers. This research work therefore focuses on one such methodology for evaluating the pattern and behavioral analysis of users in e-commerce websites. Copyright 2021, IGI Global. -
Cassava (Manihot esculenta Crantz)A potential source of phytochemicals, food, and nutritionAn updated review
Cassava (Manihot esculenta Crantz) is believed to be an important staple food crop providing potential valuable food source as well as variety of phytoconstituents. Its starchy tubers provide a significant source of energy for around 500 million individuals. Among staple crops, it is regarded to be one of the top suppliers of carbohydrates. Its physicochemical qualities, as well as its availability, have made it a captivating food component. Cassava starch is a valuable raw material used to make a variety of both native and modified starch for cooking purposes. They have also been used for a variety of industrial uses. Cassava starch and flour have the potential to be valuable alternatives to rice, maize, and wheat crops. The advantages included being a staple diet for humans, a component of animal feeds, a raw ingredient for food processing, edible coatings, locally produced alcoholic beverages, and ethanol manufacturing. The roots consist of cyanogenic glycosides, which can lead to lethal cyanide poisoning if tubers arse not properly detoxified using different processing methods include washing, fermentation, boiling, peeling and chemical processing to escape toxin content. The current review summarizes cassava's bioactive components which could be a potential source of various pharmaceutical drugs as well as a source of traditional and modern food applications. 2024 The Authors. eFood published by John Wiley & Sons Australia, Ltd on behalf of International Association of Dietetic Nutrition and Safety. -
Reversing Cell Aging - Understanding the Causes and Potential Remedies, a Current Perspective
To retain vigor, vitality and youthfulness has always been cherished as the dream of mankind from time immemorial. Scientists have been on the quest to find out the reasons for aging so that remedial measures can be thought of. With the current pace of developments in this domain, the possibility of extending one's expiry date is not so far off in the future. Through reverse cell aging, the concept of everlasting youth might no longer be a fantasy. Aging is the net result of reduction in the efficiency of physiological activities in our body essentially due to wear and tear. At the molecular level, the reasons for this include telomere shortening, oxidative stress, glycation, protein aggregation, mutation etc. Progressive damage due to these underlying causes result in pathological manifestation resulting in cell aging. The current review focuses on the causes of cellular aging, both genetic and epigenetic and discusses various approaches like telomere reactivation, epigenetic age reversal and hyperbaric oxygen treatment to reverse that condition. 2022 World Research Association. All rights reserved. -
Artificial intelligence for diabetic retinopathy detection: A systematic review
The incidence of diabetic retinopathy (DR) has increased at a rapid pace in recent years all over the world. Diabetic eye illness is identified as one of the most common reasons for vision loss among people. To properly manage DR, there has been immense research and exploration of state-of-the-art methods using artificial intelligence (AI) enabled models. Specifically, AI-empowered models combine multiple machine learning (ML) and deep learning (DL) based algorithms to improve the performance of the developed system architectures that are commercially utilized for the detection of DR disease. However, these models still exhibit several limitations, such as computational complexity, low accuracy in DR stage detection due to class imbalance, more time consumption, and high maintenance cost. To overcome these limits, a more advanced model is required to accurately predict the DR stage in the initial stages. For example, the identification of DR disease in the initial stage helps the ophthalmologist to make an accurate and safe diagnosis, and thereby, eyesight-related issues may be treated more effectively. This study conducted a systematic literature review (SLR) to provide a detailed discussion of the background of diabetic retinopathy, its major causes, challenges faced by ophthalmologists in DR detection, and possible solutions for identifying DR in the initial stage. Also, the SLR provides an in-depth analysis of the existing state-of-the-art techniques and system models used in DR diagnosis based on AI, ML, and recently developed DL-based approaches. Furthermore, this present survey would be helpful for the research community to receive information on the recent approaches used for DR identification along with their significant challenges and limitations. 2024 The Authors