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Geraniol and Citral as potential therapeutic agents targeting the HSP90 activity: An in silico and experimental approach
Lemongrass essential oil has antifungal and anti-cancerous properties. Heat-shock protein (HSP90), an ATP-dependent molecular chaperone found in eukaryotes, is involved in protein folding, stability, and disease, making it a promising research topic. Both in silico and in vitro approaches were used to provide a clear insight into the HSP90-ATPase 3D structures, activity, and their interaction with the essential oil constituents among various species such as fungi (S. cerevisiae), parasites (P. falciparum), and humans. For in silico studies, sequence alignment, docking (AutoDock), and absorption, distribution, metabolism, and excretion (ADME) properties were evaluated to obtain hit compounds specifically against each HSP90-ATPase. The hit compounds obtained were evaluated for their efficacy in the in vitro studies of S. cerevisiae. In vitro studies were carried out targeting HSP90-ATPases via lemongrass essential oil components individually and in combination as a function of concentration and various salt concentrations. Results suggest that sequence alignment exists of over 75% among these three species. The best docking score was possessed by Geraniol and its constituent (geldanamycin ? ?4.93 kcal/mol) (a known antifungal and antitumor against HSP90) in all the above species. Lemongrass oil and the combination of Geraniol and Citral at concentrations of 80 ?g/mL showed the maximum inhibition of ATPase and HSP90-ATPase activity compared to their individual treatment. Therefore, both in silico and in vitro studies provide clear evidence of specific inhibitory action of lemongrass oil, Geraniol, and Citral against the ATPase and HSP90ATPase activities and might show potential as antifungal and antitumor drugs. 2021 -
A study investigating the role of economic uncertainty and factors affecting futures indices mispricing
In this paper, we investigate (a) what are the factors that affect the mispricing in benchmark and sectoral indices; (b) the role of economic policy uncertainty (EPU) on the mispricing in future indices; and (c) is there any relationship between the magnitude of mispricing in future indices and the number of factors affecting it. The study deploys regression analysis on the 6930 observations during the period of 2009-2019 for three major indices i.e., Nifty, Nifty Bank and Nifty IT respectively. The study reports that (a) time to maturity and lag of mispricing affect all three indices positively whereas open interest affects Nifty Bank and Nifty IT negatively and spot volume affects only Nifty IT positively; (b) EPU affects positively to all three indices, reflecting that uncertainty increases the mispricing in the stock market; (c) magnitude of the mispricing is directly related to the number of factors affecting that mispricing. Copyright 2022 Inderscience Enterprises Ltd. -
Self-assembled free nanocarrier prodrugs based on camptothecin and dihydroartemisinin exhibit accumulation and improved anticancer efficacy
Small molecule targeted inhibitor therapies often have several drawbacks, including limited oral bioavailability, quick metabolism, toxic effects that limit dosage, and poor water solubility. This study aims to develop a nanodrug self-delivery system that does not require a carrier by utilizing the self-assembly of camptothecin (CPT) and dihydroartemisinin (DHA). CPT/DHA nanoparticles (NPs) with varying diameters can be synthesized without requiring further carrier materials or chemical modifications by changing the CPT-to-DHA ratio (10:1, 5:1, 2:1, 1:1). Even more crucially, CPT/DHA NPs generate an AIE impact when they self-assemble. CPT/DHA NPs are used for cell tracking and bioimaging fluorescent probes. We chose CPT/DHA NPs (2:1) with a size of approximately 140nm for the anticancer examinations. The A549 cells were used to assess the cytotoxicity, morphological changes by biochemical staining methods and apoptosis by flow cytometric techniques of CPT/DHA NPs. Finally, in vitro anticancer research proved that CPT/DHA NPs are biocompatible and have strong synergistic anticancer properties. 2024 International Union of Biochemistry and Molecular Biology, Inc. -
Diaspora Experience Between the Creation and the Creator : A Closer Look at the Diaspora Connected Character in Anita Desai's 'Fasting, Feasting'
Quest International Multidisciplinary Research Journal, Vol-1 (2), pp. 83-86. ISSN-2278-4497 -
Exploring silenced subaltern voices of three-fold oppressed dalit women in Akkarmashi by Sharankumar Limbale : A postcolonial reading /
Roots International Journal Of Multidisciplinary Researches, Vol.2, Issue 3, pp.13-15, ISSN No: 2349-8684. -
Indias role in kazakhstans multi-vector foreign policy
?fter the disintegration of the Soviet Union, Kazakhstans economy was weak since most of the industrial en-terprises were located in Russia. To attain economic growth, Kazakhstan crafted a unique foreign policy known as the multi-vec-tor foreign policy, which facilitated an easy inflow of direct foreign investments into the state economy. After economic liberalization in 1991, India took a serious interest in Cen- tral Asia, and since then the two nations have come a long way marked by complex interde-pendence in the international arena. They have demonstrated a successful and sus-tained upward trend in their bilateral relationship through soft power, trade and long-standing historical connections. Thus, the prospects of mutual cooperation between Central Asia, particularly Kazakhstan, and India are quite promising in the near future. 2021, CA and C Press AB. All rights reserved. -
Taxonomic revision and molecular phylogeny of flemingia subgenus rhynchosioides (Leguminosae)
A taxonomic revision of Flemingia subg. Rhynchosioides based on morphology and molecular information (matK and ITS) is presented. The subgenus comprises six herbaceous taxa (F. gracilis, F. mukerjeeana, F. nilgheriensis, F. rollae, F. tuberosa and F. vestita). All species except F. vestita are endemic to India. Morphological evidence and molecular phylogeny revealed that the subgenus is monophyletic. Nevertheless, the systematic position of F. tuberosa remains unclear on account of its unique ecology and inflorescence. A new species, F. mukerjeeana, is described and four binomials, namely F. gracilis, F. nilgheriensis, F. tuberosa and F. vestita have been lectotypified. Furthermore, all species have been described, illustrated and their ecology discussed. A taxonomic key including the recently described species from Thailand, F. sirindhorniae, is also provided for easy identification. 2019 Naturalis Biodiversity Center. -
Degradation of azodyes in wastewater by using hydrodynamic cavitation technique
The organic waste water discharged from various industries consists of large amounts of dyes & cyanides & other toxic carcinogenic pollutants which are harmful to human health & ecosystem. Release of carcinogenic dyes is hazardous & has a detrimental effect on the well being of an individual. The present work is focussed at finding the viability of hydrodynamic cavitations process in the degradation of dyes. To study the degradation, influence of various parameters on degradation rate has been studied. BEIESP. -
Origami foldaway support for beginners using image processing
Various origami works are distributed as origami books in which a succession of collapsing operations with basic outlines is portrayed. In any case, the origami book reader often will give up the instruction of the book middle, because it is too difficult to understand a way to fold in accordance with the diagrams. This paper proposes an approach to find the next step how to do the folding operation, especially for origami beginners. First, a method of detecting the folding operation based on camera images is been detected by canny edge detection. Then, in order to get the next operation camera image is been compare with the database images with the help of Bag of a visual word and Speed up robust features(SURF) detector to detect the key points by finding out the nearest neighboring distance ration (NNDR) measures to find out the similarities. 2016 Authors. -
Rayleigh-Bard convection in mono and hybrid nanoliquids in an inclined slot
Linear stability analysis is conducted to investigate the longitudinal and transverse rolls (TRs) generated in Rayleigh-Bard convection in mono and hybrid nanoliquids confined between two infinite inclined parallel slots. Thermophysical properties of six mono nanoliquids and fifteen hybrid nanoliquids are calculated for different volume fractions (0.5%, 1%, 2%) using phenomenological laws and mixture theory. The shooting method is used to solve boundary eigenvalue problems to obtain the eigenvalues for 16 different boundary conditions. It is observed that as the inclination angle is increased, it delays the onset of longitudinal rolls in the case of all boundary conditions. However, it advances the onset of TRs except when the lower plate is adiabatic. The addition of mono and hybrid nanoparticles results in the advancement of the onset of convection. The addition of SWCNT and SWCNT Al 2 O 3 accelerates the onset of convection the most while Cu and Cu-Ag accelerates the onset of convection the least amongst the mono and hybrid nanoparticles considered in the study. 2023 IOP Publishing Ltd. -
A Novel Assessment of Healthcare Waste Disposal Methods: Intuitionistic Hesitant Fuzzy MULTIMOORA Decision Making Approach
Waste produced from medical facilities systems incorporates a blend of dangerous waste which can posture dangers to humans and ecological receptors. Lacking administration of healthcare waste can prompt hazard to medicinal service specialists, patients, public health, communities and the wider environment. Hence, proper management of healthcare waste is imperative to reduce the associated health and environment risk. In this paper, we extend the MULTIMOORA decision making method with intuitionistic hesitant fuzzy set to evaluate the healthcare waste treatment methods. Intuitionistic hesitant fuzzy set is a generalized form of a hesitant fuzzy set. Intuitionistic hesitant fuzzy set considers the uncertainty of data in a single framework and take more information into account. The MULTIMOORA method consists of three parts namely the ratio system, reference point approach and the full multiplicative form. In the optimal ranking methods, the IHF-MULTIMOORA method is uncomplicated it is able to be used practically with high dimension intuitionistic hesitant fuzzy sets. For pathological, pharmaceutical, sharp, solid and chemical wastes, the preferred waste disposal methods are deep burial, incineration, autoclave, deep burial, and chemical disinfection, respectively. 2013 IEEE. -
The hesitant Pythagorean fuzzy ELECTRE III: An adaptable recycling method for plastic materials
In this research article, introduce a novel decision making method called HPF-ELECTRE method by extending the ELECTRE III (ELimination and Choice Expressing REality) method with HPF (Hesitant Pythagorean Fuzzy) set. The efficiency of the new method is testing in the plastic recycling problem. One of the most hazardous domestic materials is plastic. The low biodegradability nature of plastic is a serious threat to the environment and to human life. Plastic is a synthetic chemical that do not belong to the natural world. Owing to the non-biodegradability, the only way to deal with this modern-world problem is recycling. Finding a suitable recycling method for disposing and recycling plastic materials is a major research issue. Propose the HPF-ELECTRE III method to find out the adaptable recycling method for plastics materials. The outranking in HPF-ELECTRE III method expand on concordance and discordance acceptability value values. Established method is an effective tool for decision making problems. 2020 Elsevier Ltd -
A Precise Computational Method for Hippocampus Segmentation from MRI of Brain to Assist Physicians in the Diagnosis of Alzheimer's Disease
Hippocampus segmentation on magnetic resonance imaging is more significant for diagnosis, treatment and analyzing of neuropsychiatric disorders. Automatic segmentation is an active research field. Previous state-of-the-art hippocampus segmentation methods train their methods on healthy or Alzheimer's disease patients from public datasets. It arises the question whether these methods are capable for recognizing the hippocampus in a different domain. Therefore, this study proposes a precise computational method for hippocampus segmentation from MRI of brain to assist physicians in the diagnosis of Alzheimer's disease (HCS-MRI-DAD-LBP). Initially, the input images are pre-processed by Trimmed mean filter for image quality enhancement. Then the pre-processed images are given to ROI detection, ROI detection utilizes Weber's law which determines the luminance factor of the image. In the region extraction process, Chan-Vese active contour model (ACM) and level sets are used (UACM). Finally, local binary pattern (LBP) is utilized to remove the erroneous pixel that maximizes the segmentation accuracy. The proposed model is implemented in MATLAB, and its performance is analyzed with performance metrics, like precision, recall, mean, variance, standard deviation and disc similarity coefficient. The proposed HCS-MRI-DAD-LBP method attains in OASIS dataset provides high disc similarity coefficient of 12.64%, 10.11% and 1.03% compared with the existing methods, like HCS-DAS-MLT, HCS-DAS-RNN and HCS-DAS-GMM and in ADNI dataset provides high precision of 20%, 9.09% and 1.05% compared with existing methods like HCS-MRI-DAD-CNN-ADNI, HCS-MRI-DAD-MCNN-ADNI and HCS-MRI-DAD-CNN-RNN-ADNI, respectively. 2022 World Scientific Publishing Europe Ltd. -
Inter-relational dynamics of factors affecting the emergence of orphan drugs; [Dynamique interrelationnelle des facteurs influennt lergence des micaments orphelins]
Orphan drugs are medications that are produced for the treatment of rare diseases. As there is less number of patients, the drug manufacturing companies are not keen in producing these drugs. Due to high costs of research and development and low profitability, companies do not want to invest in manufacturing of orphan drugs. Several laws have been passed by Governments of different nations to encourage the development of orphan drugs and make it available to patients. This study explores the interrelation dynamics of factors that has resulted in the greater availability of orphan drugs in recent times. Ten factors: internet technology, legislation, online patient support groups, government subsidiary, biotechnological advancements, corporate social responsibility, awareness and diagnosis of rare diseases and exclusive budgeting by pharmaceutical industries for orphan drugs related research and development and production were taken for the study. With a sample size of 38 experts, the technique of decision-making trial and evaluation laboratory (DEMATEL) was used for the study. It was found that information technology, legislation, support groups, and budget were the causes and the factors awareness, diagnosis, medicine availability, subsidiary, CSR and biotechnology emerged to be the effect. 2024 Acadie Nationale de Pharmacie -
Kerala Development and the Attapadi Adivasi
The development experience of the state of Kerala in southwest India is based generally on democratic principles of equality and popular participation. This article focuses on the lives of the Adivasi1 people of Attapadi in the Palakkad district of Kerala. It argues that the state of Kerala largely treats the Adivasis as secondary citizens and ignores their right to be socially and economically empowered. The state of Kerala takes pride in its positive ranking on human development and social progress indexes but has not done enough to stop Adivasi infants from dying of malnutrition, and Adivasis demands for land rights have been disregarded. As a result, they are forced to live obscure lives in poverty and generally unable to influence their sociopolitical sphere. 2023 The Author(s). -
Surface-engineering of carbon fibre paper electrode through molecular imprinting technique towards electrochemical sensing of food additive in shrimps
Excessive usage of food additives needs to be extensively examined and regulated. Herein, we report the development of an exceptionally proficient and practical electrochemical sensor for the quantitative determination of 4-hexylresorcinol (4-HR) in shrimps using a molecularly imprinted conducting polymer. By electropolymerizing 2-aminothiazole (AT) on the surface of a carbon fibre paper electrode (CFP) in the presence of 4-HR imprinted polymer films were developed. Bulk-electrolysis was used to produce definite imprinting sites and regulate the release of 4-hexylresorcinol templates. Voltammetric study reveals that the synthesized conducting polymer has outstanding electroactivity towards 4-HR and enables quick electron transfer kinetics. This MIP sensor has a detection limit of 6.03 nM for 4-HR. The modified CFP electrode has been found to be extremely selective to 4-HR due to its intensive contact via intermolecular hydrogen bonding. The modified electrodes were characterized by Scanning Electron Microscopy, Fourier Transform Infrared spectroscopy, Optical profilometry, and X-ray Photoelectron Spectroscopy. 2022 Elsevier B.V. -
Platinum decorated phosphorous doped graphitic carbon nitride supported molecularly imprinted carbon fibre electrode as a nano-interface for the detection of butylated hydroxy anisole
This research generated an electrochemical sensor using a carbon fibre (CFP) paper electrode coated using platinum-decorated phosphorous doped graphitic carbon nitride (Pt/PgCN). This sensor was designed to detect butylated hydroxy anisole (BHA) selectively and sensitively. The molecularly imprinted polymers (MIPs) were synthesized onto the Pt/PgCN coated CFP surface through electropolymerization using BHA as a template and 3-thiophene acetic acid as monomer. Numerous analytical methods were used to characterise the sensor electrode, including cyclic voltammetry, impedance spectroscopy, and electron microscopy. The results showed that the synergetic effect of PgCN, Pt nanoparticles, and PTAA, PgCN and Pt had a positive impact on the electrochemical detection, the sensor's linear range was determined to be between 5 10?10 M and 2.1 10?7 M. The sensor demonstrated excellent stability, good reproducibility, and high selectivity for detecting BHA. Moreover, the proposed sensor successfully detected BHA in real samples. 2024 Elsevier Ltd -
Single-monomer dual templated MIP based electrochemical sensor for tartrazine and brilliant blue FCF
In this study, a dual-templated molecularly imprinted polymer-based electrochemical sensor was developed for the simultaneous analysis of two food additive dyes, brilliant blue FCF and tartrazine. Using a 3-aminophenyl boronic acid (3-APBA) monomer and the dual templates of brilliant blue FCF (BB) and tartrazine (TZ), the molecularly imprinted polymer (MIP) layer was electropolymerized on the carbon fibre paper (CFP) electrode. By using BB and TZ as template molecules along the electro-polymerization of 3-APBA, then removing both template molecules, the MIP film was generated on the surface of the CFP electrode. Due to the high surface area provided by modification, several complementary binding sites for template molecules are formed on the surface of the MIP sensor during this process of sensor fabrication. On the MIP/CFP electrode, the electrochemical behavior of BB and TZ was assessed. The monomer/template ratio, pH values, and influencing parameters like the electro-polymerization scanning cycles were all optimized. This sensor was applied to detect brilliant blue FCF and tartrazine in beverage and food samples using MIPAPBA/CFP electrode. 2023 -
Design optimisation and fabrication of amino acid based molecularly imprinted sensor for the selective determination of food additive tartrazine
In this work, we developed a new molecularly imprinted polymer detector for tartrazine's rapid and selective detection. Electropolymerisation using L-Methionine resulted in the polymer immobilised on the carbon fibre paper electrode's surface. MIP film was formed by electropolymerisation in the presence of the template tartrazine. The polymer frame comprises cavities after template removal, which can specifically bind to the analyte molecule. Without pre-treatment, the developed sensor MIPMet/CFP detects tartrazine in beverage samples precisely and rapidly. The sensor has a linear response in the concentration range of 0.6 nM- 160 nM, high sensitivity (601964 AM-1cm?2), and a low detection limit of 27 pM under optimum conditions. MIPMet/CFP sensor displayed the ability to distinguish target analyte from interferants selectively. The performance of the MIPMet/CFP sensor in assessing tartrazine in different saffron powder and packed juice samples suggests that it could be used to detect tartrazine fast and effectively. 2022 Elsevier Ltd -
Marital Stress and Domestic Violence during the COVID- 19 Pandemic
Marital stress and domestic violence is prevalent in every society around the world. It has become a major concern during the Covid-19 pandemic. Governments have resorted to lockdown measures in order to contain the pandemic. The pandemic has made the weaker and more vulnerable people in a household more exposed to abusive partners. Social isolation and home confinement have detrimental effects on ones mental and physical well-being. Women have been shown to be at a very high risk from violence during The Covid19 pandemic. The research paper aims to understand the factors which compel women to stay in abusive and stressful marriages and the ways in which they can be empowered to lead their life with dignity and self-respect. The cultural contexts of most societies force women to stay in abusive marriages as the woman is often portrayed as the symbol of unity in families. Understanding the cultural bindings of women trapped in abusive households during the COVID-19 pandemic is a very crucial aspect as this can help in understanding the fear and apprehensions of women trapped in destructive marriages. This can be a key factor which can make it easier for support groups while providing counselling and other kinds of support to women trapped in abusive marriages. The paper also discusses the impact of abusive relationships on children and how it negatively shapes their personality and their emotional well- being. 2021 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license.