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Child sexual abuse prevention involving mothers: A Quasi-experimental study with Protection Motivation Theory-based intervention
Child sexual abuse (CSA) is a worldwide problem. The safety of children is everybody's responsibility. Parental and family involvement is crucial in the CSA prevention process. Parental lack of knowledge may increase the risk of abuse among children. Educating parents is crucial as children are mostly dependent on them. The role of mothers in educating children on CSA is of relevance as they are identified as more sensitive and responsible caregivers. The present study aimed to promote knowledge and attitude towards CSA prevention among mothers through a psychoeducation program. A pre- and posttest design (n = 67) was used with an intervention based on Protection Motivation Theory (PMT). A CSA knowledge and attitude scale was developed for the assessment of the participants for the study. There were significant changes in knowledge and attitude among the participants after the intervention. The prevention of CSA will be effective with knowledge gains after the PMT-based intervention. The intervention programs that involve mothers in CSA education have benefits. The findings of this study can be helpful to incorporate public health approaches to devise evidence-based parental programs in community settings. 2022 Wiley Periodicals LLC. -
Children Witnessing Violence in India: Nature, Risk Factors, Impact and Prevention Strategies
Children witness various degrees and intensities of violations and violence along with a hoard of environmental stressors. Such a spectrum of violence includes disturbing family environments, witnessing adults, including parents and family members, indulge in violence and abusive behaviours and direct or vicarious exposure to violence outside the home. The chapter aims to provide an overview of the nature and impact of witnessing violence. The frequency, type, intensity and the child's relationship with the people involved or impacted by the violence can determine the impact on a child's mental health and development. Children may witness distressing events in their daily lives like the loss of a loved one or watching adults take up challenging tasks, which may help them be resilient and learn coping skills with appropriate support. Long-term exposure to witnessing violence and trauma can lead to severe emotional and developmental difficulties. Such direct or vicarious exposure to varying degrees of violence may cultivate a culture of fear, repression and silence around the children. These difficulties may be similar to those of children who are direct victims of abuse. Witnessing violence has also been linked to anxiety and depression. Children growing up in such environments are at higher risk of normalizing violence and growing into abusive adults. Poverty, cultural factors, parenting, schooling, and policies can largely determine such risks for children. The paper discusses the preventive and promotive approaches at the school, family and community levels. Education and empowerment of adults in the child's environment can be the best preventative approach. Existing policies and programmes in India for children need to bring in more robust initiatives to identify, report, prevent and protect children witnessing violence. The needs and concerns of children witnessing violence and prevention approaches should be part of courses in helping professionals training and curriculum. The chapter calls for the necessity of individual and community-based interventions in terms of need-based models for addressing the mental health needs of children. The chapter strongly recommends the need for addressing mental health education for families and schools. The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2022. -
Chinese maritime relations with Malabar Coast, 12001500 AD: A quest for naval dominance
China has had a long history of maritime expedition. Its Indian Ocean connectivity, long before European explorers arrived at the Malabar Coast, had made significant impact on the maritime trade in the Indian Ocean region. Chinas expedition to the Southern Asia was aimed to expand the benevolence of Chinese emperor and to establish its suzerainty in maritime trade rather than to establish the permanent position on land. The political dynamics at home caused the rise and fall of the maritime might of China. The famous explorer, Zheng Hes expeditions represented Chinas ambition to expand its control over the Indian Ocean regions. The Malabar Coast with its geographical advantages had developed maritime activities enhancing its commercial fortunes. China had to accept the strength of Malabar kingdoms in terms of political power, trade and commercial advantages. Importantly, Malabar kingdoms did not accept the Chinese assertions of supremacy but engaged with the Chinese on equal terms. An attempt is made here to trace Chinas maritime strategy to expand their power beyond the immediate periphery and establish its supremacy in the Indian Ocean. 2019, 2019 National Maritime Foundation. -
ChIPSeq Analysis with Bayesian Machine Learning
ChIP-sequencing, otherwise called ChIP-seq, is a technique used to identify protein co-operations with DNA. A crucial advancement to the field of bio-informatics, ChIP sequencing is conducted in research labs around the world to get a better understanding of the way transcription factors and other associated proteins influence the gene in many biological processes and in tackling disease states. ChIP-seq is predominantly a field under the domain of biotechnology, however recent advancements and development of tools to process ChIP data have turned the study into one involving bio-informatics, allowing computer scientists and lab technicians to work on an otherwise scholarly field of biochemistry, molecular biology, microbiology and biomedicine. This report illustrates the predominant work-flow undertaken to sequence chromatin from a cell and to gain insights on the gene/protein of interest. Another aspect added is to use Machine Learning with Bayesian statistical techniques for Peak Calling. The different stages enumerated in this paper have been completed either with the R language or on a Web Server titled Galaxy.org. 2019 IEEE. -
Chitosan stabilized platinum nanoparticles: Synthesis, characterization and cytotoxic impacts on human breast cancer cells
Platinum nanoparticles are widely studied as a nanomedicine against many of the solid tumours. Due to their promising physicochemical properties, chitosan-stabilized platinum nanoparticles may exhibit exceptional cytotoxic effects on cancer cells. This article describes the synthesis and characterization of chitosan-stabilized platinum nanoparticles (Ch-Pt NPs) through a wet chemical method and in vitro studies of their anticancer effect on human breast cancer cells (MCF-7 cell line). Different analytical methods confirmed the formation of chitosan-stabilized platinum nanoparticles. The structural and surface morphological analyses were done using XRD, FTIR, TEM, FESEM, etc. Elemental analysis was done using XPS and EDX. The hydrodynamic diameter and zeta potential were determined using DLS and zeta analyzer. These platinum nanoparticles have a spherical shape and FCC structure with an average particle size of 3.4 nm and an average hydrodynamic diameter of 248 nm. The characteristic FTIR peaks of chitosan in the sample confirmed the capping of chitosan on the surface of the Pt NPs. The surface charge estimation using a zeta potential analyzer showed ?23.8 mV, elucidating the stability and dispersity of the as-synthesized Pt NPs. The in vitro cytotoxicity study using MTT assay revealed a non-toxic behaviour on normal L929 cell lines and a severe anti-proliferative activity on a human breast cancer (MCF-7) cell line with an IC50 value of 35.60 ?g/ml after 24 h of incubation. This result indicates a better anticancer therapeutic application against human breast cancer cells for the as-synthesized chitosan-stabilized platinum nanoparticles. 2024 Elsevier B.V. -
Chlorin e6 decorated doxorubicin encapsulated chitosan nanoparticles for photo-controlled cancer drug delivery
In the study we have reported the physico-chemical, photophysical and morphological properties of chlorin e6 (Ce6) decorated doxorubicin (DOX) encapsulated chitosan (CS)-tripolyphosphate (TPP) nanoparticles which prepared by ionotropic gelation method. The Ce6 physically loaded onto the nanoparticles by self-assembly of CS with TPP-DOX under aqueous conditions. The results from DLS studies highlights the prepared nanoparticles that possess the size in the range of 80120 nm. with negatively charged of ?6 mV. The SEM and AFM images showed 80120 nm size while the average size of the Ce6 decorated nanoparticles was found to be around 100130 nm. The absorption spectra of Ce6 decorated nanoparticles are similar when compared to free Ce6 which suggest there is no change in the Ce6 chromophore upon decoration. This nanoparticle showed high photostability and singlet oxygen generation (SOG). The Ce6 decorated and DOX encapsulated nanoparticles sizes and charges are in the range of 90130 nm and ?30 mV respectively. The nanoparticles showed high encapsulation efficiency towards DOX as well as pH controlled release. This has significant anti-proliferative activity against MCF-7 breast cancer cells after irradiation at near infra-red (NIR) ranges were evaluated. This could have potential applications in photo-controlled smart DOX delivery system for cancer treatment. 2019 Elsevier B.V. -
Chloroform fraction of Chaetomorpha brachygona, a marine green alga from Indian Sundarbans inducing autophagy in cervical cancer cells in vitro
Sundarbans Mangrove Ecosystem (SME) is a rich repository of bioactive natural compounds, with immense nutraceutical and therapeutic potential. Till date, the algal population of SME was not explored fully for their anticancer activities. Our aim is to explore the potential of these algal phytochemicals against the proliferation of cervical cancer cells (in vitro) and identify the mode of cell death induced in them. In the present work, the chloroform fraction of marine green alga, Chaetomorpha brachygona was used on SiHa cell line. The algal phytochemicals were identified by GCMS, LCMS and column chromatography and some of the identified compounds, known for significant anticancer activities, have shown strong Bcl-2 binding capacity, as analyzed through molecular docking study. The extract showed cytostatic and cytotoxic activity on SiHa cells. Absence of fragmented DNA, and presence of increased number of acidic vacuoles in the treated cells indicate nonapoptotic cell death. The mode of cell death was likely to be autophagic, as indicated by the enhanced expression of Beclin 1 and LC3BII (considered as autophagic markers) observed by Western blotting. The study indicates that, C. brachygona can successfully inhibit the proliferation of cervical cancer cells in vitro. 2020, The Author(s). -
Cholesterol reduction and heavy metal assimilation characteristics of Pediococcus pentosaceus strains isolated from pickle and moor-kuzhambu
Aims: Consumption of fermented foods are known to provide various health benefits. The present study was aimed to isolate novel potent probiotic strains from the homemade fermented Indian recipe Moor Kuzhambu and Pickle and its characterization to elucidate the efficacy of isolate in cholesterol and heavy metal reduction. Methodology and results: Cultures isolated from Pickle (CK2) and Moor Kuzhambu (CK3) were identified as different strains of Pediococcus pentosaceus using the 16S rDNA sequence-based bacterial identification method. The study analysed the survival of probiotic strains under the influence of various chemical and natural stimulants. The isolated strains exhibited tolerance to gastric juice and were able to exhibit a broad range of tolerance to varying temperatures, pH, NaCl, solvent, phenol, trypsin and artificial gastric juice. Microencapsulation studies were conducted using alginate and chitosan to increase the shelf life of the isolated probiotic. Preliminary analysis regarding cell surface studies such as autoaggregation, co-aggregations and cell surface hydrophobicity determined the ability of the strains to aggregate on to intestinal cell surface and manifest competitive pathogen displacement. Conclusion, significance and impact of study: Remarkable biofilm reduction of 48% to 80% was observed in the probiotic-supplemented samples. Similarly, a reduction of 80% to 85% free cholesterol was noted in cholesterol assimilation assays and heavy metal (Cu+, Pb+, Zn+ and Fe+) assimilation ability was observed. Further studies are required to characterize the nature of the secretory products and their mode of action in the survival and immune enhancement in animal models. 2023, Malaysian Journal of Microbiology. All Rights Reserved. -
Chromatic completion number
The well known concept of proper vertex colouring of a graph is used to introduce the construction of a chromatic completion graph and determining its related parameter, the chromatic completion number of a graph. The chromatic completion numbers of certain classes of cycle derivative graphs and helm graphs are then presented. Finally, we discuss further problems for research related to this concept. 2020 the author(s). -
Chromatic Zagreb and irregularity polynomials of graphs
Graph coloring is an assignment of colors, labels or weights to elements of a graph subject to certain constraints. Coloring the vertices of a graph in such a way that adjacent vertices are having different colors is called proper vertex coloring. A proper vertex coloring using minimum parameters of colors is studied extensively in recent literature. In this paper, we define new coloring related polynomials, called chromatic Zagreb polynomials and chromatic irregularity polynomials, in terms of minimal parameter coloring and structural characteristics of graphs such as distances and degrees of vertices. 2021 World Scientific Publishing Company. -
Cinema and the non-violence versus violence discourse: a review of the film RRR
[No abstract available] -
Cinnamon A Competent Drug: A Review on Extraction, Analysis and Anticancer Action
Cinnamon, an Indigenous species, is extensively used as a folk medicine in India, China, and other parts of the world due to its therapeutic potential inherited via the latent chemical composition. The vital component presented is cinnamaldehyde, along with cinnamic acid and cinnamate, which contributes to being an anti-inflammatory, antimicrobial, antidiabetic, and anticancer agent together with the capability to control neurological syndromes like Alzheimer's and even Parkinson's diseases. Given the importance of the anticarcinogenic properties of cinnamon on various cell strains concerning the curable effect, this review focuses on evaluating different extraction methods like steam distillation, Soxhlet extraction, microwave-assisted extraction, and more, in addition to a summary of new technologies like gas chromatography, HPLC, DART-MS, and NMR, etc. which paved the way in characterizing the chemical composition of cinnamon. Cinnamaldehyde showed its apoptosis through various mechanistic pathways on an adequate number of cell lines and antineoplastic potential on specific multifaceted cancerous cells, which advocates for continued research and investment in this vital area of drug discovery and suggestions for future scope. 2024 Wiley-VCH GmbH. -
Cipher Block Chaining Support Vector Machine for Secured Decentralized Cloud Enabled Intelligent IoT Architecture
The growth of internet era leads to a major transformation in a storage of data and accessing the applications. One such new trend that promises the endurance is the Cloud computing. Computing resources offered by the Cloud includes the servers, networks, storage, and applications, all as services. With the advent of Cloud, a single application is delivered as a metered service to numerous users, via an Application Programming Interface (API) accessible over the network. The services offered via the Cloud are such as the infrastructure, software, platform, database and web services. The main motivation of this application model is to provide computationally secure key generation to protect the data via encryption. This key generation in the cryptography process falls into three categories in this research work. In the first part, SVM based encryption service model is constructed for which the key generation is from the conventional encryption operation mode with some improvements. To make the process more complex, the optimization techniques are taken into account for the key generation in descendant two methods application model that acts computationally more secure specifically for Cloud environment. The results of security analysis confirm the effectiveness of the proposed application model withstands potentially against various attacks such as Chosen Cipher Attack, Chosen Plain text Attack indistinguishable attacks for files. In case of images, it resists well against statistical and differential attacks. Comparative Analysis shows evidence of the efficiency of the developed pioneering application model quality and strength compared with that of the existing services. 2013 IEEE. -
Circuit Breaker: A Resilience Mechanism for Cloud Native Architecture
Over the past decade, the utilization of cloud native applications has gained significant prominence, leading many organizations to swiftly transition towards developing software applications that leverage the powerful, accessible, and efficient cloud infrastructure. As these applications are deployed in distributed environments, there arises a need for reliable mechanisms to ensure their availability and dependability. Among these mechanisms, the circuit breaker pattern has emerged as a crucial element in constructing resilient and trustworthy cloud native applications in recent times. This research article presents a comprehensive review and analysis of circuit breaker patterns and their role within cloud-native applications. The study delves into various aspects of circuit breakers, encompassing their design, implementation, and recommended practices for their utilization in cloud native applications. Additionally, the article examines and compares different circuit breaker libraries available for employment in modern software development. The paper also presents a concept for improving the circuit breaker pattern, which will be pursued in our upcoming research. 2023 IEEE. -
Circular supply chains in manufacturingQuo vadis? Accomplishments, challenges and future opportunities
Circular approach in manufacturing supply chain (SC) operations yields multiple benefits through optimal utilisation and consumption of resources. This study maps the scope and structure of circularity in the manufacturing SC discipline and explores the evolution of the domain over time. We review 946 journal articles published between 2013 and September 2023. Our study identifies key drivers and barriers to circular economy (CE) deployment in manufacturing SC operations, bibliometric parameters, emerging research themes, decision support tools, theories and applications. Using the theory extension approach, we propose a strategic framework to fortify the deployment of circularity in SCs. This comprehensive study renders a methodological contribution through combined descriptive content analysis and bibliometric and network analyses to evaluate the circular manufacturing SC operations concepts, theories and applications. We posit that manufacturing firms require to deploy innovation-led approaches to embed the CE strategies in their SC operations. We find that the studies investigating green skill development and circularity-culture adoption can facilitate manufacturers to understand the efficacy of circularity in their SC operations. The findings of this study can facilitate the practitioners to identify the links between the CE approaches and their strategic implications and examine CE implementation at the strategic level. 2024 The Authors. Business Strategy and The Environment published by ERP Environment and John Wiley & Sons Ltd. -
Citizen data in distributed computing environments: Privacy and protection mechanisms
Data security is paramount in the increasingly connected world. Securing data, while in transit and rest, and while under usage, is essentialfor deriving actionable insights out of data heaps. Incorrect or wrong data can lead to incorrect decisions. So, the confidentiality and integrity of data have to be guaranteed through a host of technology-inspired security solutions. Organizational data is kept confidentially by the businesses and governments, often in distant locations (e.g., in cloud environments), though more sensitive data is normally kept in house. As the security mechanisms are getting more sophisticated, cyber security attacks are also becoming more intensive, so there is a constant battle between the organisations and the hackers to be one step ahead of the other. In this chapter, the aim is to discuss various mechanisms of accomplishing citizens ' data confidentiality and privacy and to present solution approaches for ensuring impenetrable security for personal data. 2021 by IGI Global. All rights reserved. -
Citizens Perception on Livability in Indian Metropolitan Cities
Background: Livability is a complex and multifaceted concept, but is important in creating places where people can thrive. Investing in the factors contributing to livability can create more attractive, sustainable, and equitable communities. Livability is important for several reasons. It can affect peoples health, well-being, and productivity. It can also influence whether people live in a particular place and whether businesses are willing to invest there. Methods: A survey was conducted to review the top livable cities of India as per the Global Livability Index parameters such as sociocultural, environmental, healthcare, education, and infrastructure aspects. A mixed method approach, having both qualitative and quantitative analyses, was adopted for the survey. The targeted sample size was 100 people, covering stakeholders from around the campus. Findings: As an outcome of the survey analysis, the most livable cities were categorized. Conclusion: In conclusion, policy narratives and frameworks are outlined emphasizing the need and the importance of citizens participation in assessing the quality of life across Indian metropolitan cities. 2024 Springer Publishing Company. -
Citric-Acid-Catalyzed Green and Sustainable Synthesis of Novel Functionalized Pyrano[2, 3-e]pyrimidin- and Pyrano[2, 3-d]pyrazol-amines in Water via One-Pot Multicomponent Approaches
An efficient entry into the preparation of elusive, novel pyrano[2, 3-e]pyrimidin-amines and pyrano[2, 3-d]pyrazol-amines has been accomplished using citric acid as a green catalyst in aqueous medium at 25 C. The strategy successively tolerates a variety of functional groups and interestingly, it is eco-compatible, environment-friendly, propitious and the products are obtained in excellent yields without chromatographic purification. The current methodology unfolds the benefits of citric acid as an effective, expeditious, economical, green catalyst and thus adheres to the principles of green chemistry. Ecstatically, the reaction was scaled to the gram level ascertaining the wide applicability of the protocol in academia and industry. The green metrics (E-factor: 0.0497, Mass intensity: 1.1022, PMI: 1.0497 and Emw: 0.0497) for the reaction was also envisaged and the pathway was found to acquaint excellent green chemistry metrics. 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim -
Citrus for wellness: Exploring the bioactive properties of Citrus medica fruit peel with emphasis on its anticancer, antioxidant, antimicrobial and anthelmintic properties
Citrus medica (Citron) is an underutilised plant consisting of various bioactive elements with numerous medicinal benefits. The present study aimed to evaluate the bioactive properties, including anthelmintic, antimicrobial, antioxidant and anticancer activities, of chloroform extract obtained from the of fruit peel of C. medica. The different types of phytochemicals present in the chloroform extract were analysed using GC-MS. The major components detected included n-hexadecanoic acid, octadecanoic acid, t-tetradecenal, 1-nonadecene etc. Anthelmintic study was conducted using Eisenia fetida as a test organism, revealing a significant anthelmintic effect in the C. medica fruit peel extract compared to the standard drug. Antimicrobial properties were assessed against five test bacterial and fungal strains. Antibacterial tests showed zones of inhibition ranging from 8 to 11 mm, while no prominent zones of inhibition were observed in antifungal tests. The DPPH assay demonstrated significant antioxidant properties of Citron fruit peel extract compared to the standard ascorbic acid. The Chloroform extract of citron fruit peel exhibited significant cytotoxic properties against FaDu (human hypopharyngeal tumour) cell line. The present study indicates the potential of the chloroform extract of C. medica fruit peel to be employed as an anthelmintic, antibacterial, antioxidant and anticancer agent. Hence, it emphasises the prominence that can be given to the dietary consumption of citrus fruit peel in various forms, such as dried peel, powder etc. The Author(s). -
Citrus Medica-derived Fluorescent Carbon Dots for the Imaging of Vigna Radiate Root Cells
Bio-imaging is a crucial tool for researchers in the fields of cell biology and developmental biomedical sector. Among the various available imaging techniques, fluorescence based imaging stands out due to its high sensitivity and specificity. However, traditional fluorescent materials used in biological imaging often suffer from issues such as photostability and biocompatibility. Moreover, plant tissues contain compounds that cause autofluorescence and light scattering, which can hinder fluorescence microscopy effectiveness. This study explores the development of fluorescent carbon dots (Cm-CDs) synthesized from Citrus medica fruit extract for the fluorescence imaging of Vigna radiata root cells. The successful synthesis of CDs with an average size of 6.7nm is confirmed by Transmission Electron Microscopy (TEM). The X-ray diffraction (XRD) analysis and raman spectroscopy indicated that the obtained CDs are amorphous in nature. The presence of various functional groups on the surface of CDs were identified by Fourier transform infrared (FTIR) spectra. The optical characteristics of Cm-CDs were studied by UV-Visible spectroscopy and photoluminescence spectroscopy. Cm-CDs demonstrated strong excitation-dependent fluorescence, good solubility, and effective penetration in to the Vigna radiata root cells with multicolor luminescence, and addressed autofluorescence issues. Additionally, a comparative analysis determined the optimal concentration for high-resolution, multi-color root cell imaging, with Cm-CD2 (2.5mg/ml) exhibiting the highest photoluminescence (PL) intensity. These findings highlight the potential of Cm-CDs in enhancing direct endocytosis and overcoming autofluorescence in plant cell imaging, offering promising advancements for cell biology research. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.