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Anticancer activity and other biomedical properties of ?-sitosterol: Bridging phytochemistry and current pharmacological evidence for future translational approaches
Sterols, including ?-sitosterol, are essential components of cellular membranes in both plant and animal cells. Despite being a major phytosterol in various plant materials, comprehensive scientific knowledge regarding the properties of ?-sitosterol and its potential applications is essential for scholarly pursuits and utilization purposes. ?-sitosterol shares similar chemical characteristics with cholesterol and exhibits several pharmacological activities without major toxicity. This study aims to bridge the gap between phytochemistry and current pharmacological evidence of ?-sitosterol, focusing on its anticancer activity and other biomedical properties. The goal is to provide a comprehensive understanding of ?-sitosterol's potential for future translational approaches. A thorough examination of the literature was conducted to gather relevant information on the biological properties of ?-sitosterol, particularly its anticancer therapeutic potential. Various databases were searched, including PubMed/MedLine, Scopus, Google Scholar, and Web of Science using appropriate keywords. Studies investigating the effects of ?-sitosterol on different types of cancer were analyzed, focusing on mechanisms of action, pharmacological screening, and chemosensitizing properties. Modern pharmacological screening studies have revealed the potential anticancer therapeutic properties of ?-sitosterol against various types of cancer, including leukemia, lung, stomach, breast, colon, ovarian, and prostate cancer. ?-sitosterol has demonstrated chemosensitizing effects on cancer cells, interfering with multiple cell signaling pathways involved in proliferation, cell cycle arrest, apoptosis, survival, metastasis invasion, angiogenesis, and inflammation. Structural derivatives of ?-sitosterol have also shown anti-cancer effects. However, research in the field of drug delivery and the detailed mode of action of ?-sitosterol-mediated anticancer activities remains limited. ?-sitosterol, as a non-toxic compound with significant pharmacological potential, exhibits promising anticancer effects against various cancer types. Despite being relatively less potent than conventional cancer chemotherapeutics, ?-sitosterol holds potential as a safe and effective nutraceutical against cancer. Further comprehensive studies are recommended to explore the biological properties of ?-sitosterol, including its mode of action, and develop novel formulations for its potential use in cancer treatment. This review provides a foundation for future investigations and highlights the need for further research on ?-sitosterol as a potent superfood in combating cancer. 2023 John Wiley & Sons Ltd. -
Magical mushroom Ganoderma-A Promising treatment for cancer
[No abstract available] -
Updated aspects of alpha-Solanine as a potential anticancer agent: Mechanistic insights and future directions
Cancer remains a critical global health challenge, with limited progress in reducing mortality despite advancements in diagnosis and treatment. The growing resistance of tumors to existing chemotherapy exacerbates this burden. In response, the search for new anticancer compounds from plants has intensified, given their historical success in yielding effective treatments. This review focuses on ?-solanine, a glycoalkaloid primarily derived from potato tubers and nightshade family plants, recognized for its diverse biological activities, including anti-allergic, antipyretic, anti-inflammatory, anti-diabetic, and antibiotic properties. Recently, ?-solanine has gained attention as a potential anticancer agent. Utilizing resources like PubMed/MedLine, ScienceDirect, Web of Science, Scopus, the American Chemical Society, Google Scholar, Springer Link, Wiley, and various commercial websites, this review consolidates two decades of research on ?-solanine's anticancer effects and mechanisms against nine different cancers, highlighting its role in modulating various signaling pathways. It also discusses ?-solanine's potential as a lead compound in cancer therapy. The abundant availability of potato peel, often discarded as waste or sold cheaply, is suggested as a sustainable source for large-scale ?-solanine extraction. The study concludes that ?-solanine holds promise as a standalone or adjunctive cancer treatment. However, further research is necessary to optimize this lead compound and mitigate its toxicity through various strategies. 2024 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC. -
A Comparative Study on Blockchain Architectures for Secure and Transparent Healthcare Systems
The research compares blockchain technologies in the healthcare industry, focusing on data security, decentralization, and transparency for managing data. Traditional healthcare systems face challenges, notably data breaches, inefficiencies in maintaining records, less interoperability, and issues regarding patient privacy. The solution with the use of the distributed nature of blockchain as an advantage is to provide a secure, decentralized space to store and manage medical data that is sensitive for creating a transparent, tamper-proof ledger accessible only by individuals or parties that are authorized. This paper highlights a comprehensive study of several blockchain architectures and applications in industry, such as electronic health records (EHRs), securing patient identity, tracking of drug supply chain, and secure medical data sharing. The approaches enhance data security and provide a transparent and trustworthy record of all data within a system. After analyzing numerous mechanisms and encryption approaches and combining blockchain with emerging technologies such as artificial intelligence (AI) and the Internet of Things (IoT), this chapter surveys blockchains prospect of enhancing healthcare efficiency while holding security and regulatory compliance. Likewise, the chapter discusses the restrictions of blockchain, including scalability, computational expenses, and lawful challenges, providing an understanding of forthcoming study trends and adoption methods for blockchain-based healthcare solutions. 2026 Anindya Nag, Md. Mehedi Hassan, Riya Sil and Asif Karim. -
To study the factors of consumer involvement in fashion clothing /
International Journal Of Science And Research, Vol.3, Issue 7, pp.542-546, ISSN No: 2319-7064. -
Finding balance in a digital world: Equanimity as a predictor of nomophobia
The present study examined the relationship between equanimity and nomophobia. The study also examined the differences in experience of nomophobia considering gender, education and employment status. The sample included 216 emerging adults (M = 64, F = 152) from across India. The Equanimity Scale 16 and the Nomophobia Questionnaire were used to measure equanimity and nomophobia, respectively. Mann-Whitney-U test and Rank-Biserial coefficient indicated that gender differences significantly affected the losing connectedness factor of nomophobia. Correlation analysis showed that equanimity had a significant negative relationship with nomophobia and its factors- not being able to access information, giving up convenience and losing connectedness. Regression analysis showed equanimity as a significant predictor of nomophobia. The studys findings hold potential implications for equanimity-based interventions for nomophobia and individual well-being, technological design improvements in the digital age and unfolds areas for future research. 2024 Taylor & Francis Group, LLC. -
Finding balance in a digital world: Equanimity as a predictor of nomophobia
The present study examined the relationship between equanimity and nomophobia. The study also examined the differences in experience of nomophobia considering gender, education and employment status. The sample included 216 emerging adults (M = 64, F = 152) from across India. The Equanimity Scale 16 and the Nomophobia Questionnaire were used to measure equanimity and nomophobia, respectively. Mann-Whitney-U test and Rank-Biserial coefficient indicated that gender differences significantly affected the losing connectedness factor of nomophobia. Correlation analysis showed that equanimity had a significant negative relationship with nomophobia and its factors- not being able to access information, giving up convenience and losing connectedness. Regression analysis showed equanimity as a significant predictor of nomophobia. The studys findings hold potential implications for equanimity-based interventions for nomophobia and individual well-being, technological design improvements in the digital age and unfolds areas for future research. 2024 Taylor & Francis Group, LLC. -
Sustainable Marketing and Green Finance: Integrating ESG Metrics into Financial Reporting and Strategic Branding
As sustainability gains significance in the global business landscape, an increasing number of companies are adopting Environmental, Social, and Governance (ESG) frameworks to enhance transparency and strengthen stakeholder relationships. This study looks at how using ESG metrics in branding and financial reporting affects the creation of long-term corporate value. The main goal is to find out how combining ESG initiatives with marketing plans and financial disclosures affects brand equity and financial credibility. There are both qualitative and quantitative parts to the study. This involves a qualitative analysis of ESG reports from 150 multinational corporations and the utilization of quantitative regression methods to examine the impact of ESG integration on brand performance and financial metrics. The Global Reporting Initiative (GRI) set the rules for ESG scores. Return on Assets (ROA) and Tobin's Q were the most important financial measures. The results show that companies with high levels of ESG integration saw a 12.4% increase in ROA and a 0.38 average increase in Tobin's Q compared to companies with low levels of ESG activity. Both changes were statistically significant at p < 0.01. Survey data also showed that companies that closely linked their ESG disclosures to their branding had a brand trust index that was 22% higher. These results show that strategically branded, ESG-focused reporting not only improves financial performance but also makes consumers feel better about the company. Ultimately, the study offers a framework for integrating ESG metrics into financial and marketing strategies, emphasizing ESG's function as both a moral obligation and a source of competitive advantage in the context of responsible capitalism. Sireesha Nanduri et al. -
Narratives of the self: Comments and confessions on Facebook
Narratives are structured around events, which are used to tell a story. The self is perpetually being constructed through narratives of experience. This chapter focuses on the phenomenon of Facebook confession pages and how they contribute to the construction of digital identity. Drawing on insights from my project on the role of Facebook College Confession pages, the chapter examines how these platforms have transformed the way users express and shape their identities. The anonymity provided by these pages allows users to post confessions without revealing their identities, encouraging a form of virtual self-exploration. These confessions, often written by nameless authors, generate a complex and ongoing narrative of identity, shaped by the interaction of multiple voices and viewpoints. The chapter also explores the motivations behind sharing personal confessions, even when the responses may be negative, and how this contributes to the perpetual construction of the digital self. By examining the intersection of public and private spheres in these online spaces, this chapter highlights how the breaking of the public-private divide enables users to create and negotiate their identities in a digital, networked world. The narrative constructed is endless, and the post is not an end in itself. It paves the way for the generation of an endless narrative by multiple authors with multiple viewpoints. This chapter explores the reasons behind sharing such posts on Facebook, even if the comments are negative in tone. It will refer to Anthony Giddens' concept of time-space "distanciation" (Keefer et al., 2019) to show how multiple tellers through their narratives help to build the complex networked identity of a user. The study will also analyse the role played by the breaking of the public-private divide in creating such spaces for the construction of a private self through public voices. 2024 Rimi Nandy. -
Rays Women and Sartorial Choices: Exploring Through Colonial and Feminist Perspective
[No abstract available] -
IoT and Sustainability Energy Systems: Risk and Opportunity
As IoT (Internet of Things) and smart technologies have developed rapidly, many technological advancements have been made possible. The IoTs main objective is to assist in simplifying processes in a number of different felds, to improve the effciency of technologies and protocols, and ultimately to improve quality of life. Although IoT technologies can beneft the population in numerous ways, their development must be evaluated from an environmental viewpoint to ensure that global resources are used effciently and to prevent negative effects. As previously described, considerable research effort is needed to explore the advantages and disadvantages of IoT technologies. Engineering professionals, industrial experts, and academic researchers successfully interacted at the conference. Several key tracks made up the conference, including smart city, energy and environment, e-health, and engineering modeling. Specifcally, the editorial covered a number of topics including (i) IoT in sustainable energy and environmental management, (ii) smart cities enabled by IoT, (iii) ambient assisted living, and (iv) IoT technologies for transportation and low-carbon products. An important outcome of our introductory analysis has been a greater understanding of both the scientifc developments in IoT applications and the potential ecological consequences associated with increasing IoT applications. The Author(s), under exclusive license to Springer Nature Switzerland AG 2023. -
Optimizing Portfolio for Highly Funded Industries Within Budget Constraints for the Period of 20232024
This research paper aims to analyze and optimize portfolios for the top funded industries based on the budget23. The study uses a data-driven approach to identify the best investment opportunities within these industries. The methodology involves collecting financial data, conducting market analysis, and using optimization techniques to create an optimal portfolio. The results of the study show that the top funded industries have a high potential for growth, and the optimized portfolios can maximize returns while minimizing risk. The findings can provide valuable insights for investors and fund managers who are seeking to make informed investment decisions in these industries. The study also highlights the importance of considering the budget constraints while optimizing portfolios. The Author(s), under exclusive license to Springer Nature Switzerland AG 2024. -
Quantum Information Processing for Legal Applications through Bloch Sphere of Law
The objective of the research work is to propose a quantum information processing model (QIP) for legal applications including litigation and investigation phases. The quantum information processing and quantum computing concepts can be visualized within a Bloch Sphere of Law (BSL) as legal Bloch vectors (LBV) as quantum computing entities. This quantum approach is needed since the complexity of legalities and the legal objects involved in the final judgement are to be reversible with a lot of uncertainties. The reasoning and prosecution through various trials and investigations are to be considered as mathematical matrix or unitary operations in this muti dimensional legal space. The mapping of legal information into technical and then vectorial representations are deployed through a glossary of legal terms in this quantum paradigm. As a forerunning study and application in the quantum paradigm, mathematical and computational models have been proposed in the work with a case study of a recent civil case. 2022 IEEE. -
Edge intelligence to smart management and control of epidemic
The effects of COVID-19 vary from person to person. A pandemic is devastating economically and socially. Thousands of enterprises face the possibility of collapse. More than half of the world's 3.3 billion workers may lose their livelihoods if the current crisis continues. The world's healthcare services are facing an unprecedented situation due to the recent outbreak of a novel coronavirus (COVID-19). Community and government health are adversely affected by the COVID-19 pandemic. COVID-19 has continued to spread, and mortalities have risen steadily. The spread of this disease can therefore be controlled utilizing nonpharmacological methods, such as quarantine, isolation, and public health education. Recent breakthroughs in deep learning (DL) have led to an explosion in applications and services relating to artificial intelligence (AI). The rapid advancements in mobile computing and AI have enabled zillions of Bytes of data to be generated at the network edge from thousands of mobile devices and internet of things (IoT) devices connected to the Internet. As a result of the success of IoT and AI technologies, it is of utmost importance that we expand the AI frontiers to the network edge in order for big data to be fully tapped. Edge computing (EC) can help overcome this trend because it allows computation-intensive AI applications to run on edge hardware. The topic of discussion in this chapter is edge intelligence (EI) technology's application in limiting virus spread during pandemics. 2024 Apple Academic Press, Inc. All rights reserved. -
A Reliable Method of Predicting Water Quality Using Supervised Machine Learning Model
Water contributes to around 70% of the world's exterior and is perhaps the primary source essential to supporting life. The rapid growth of urban and industrial geographies has prompted a disintegration of the quality of water at a concerning pace, bringing about nerve-racking sicknesses. Water quality has been expectedly assessed through costly and tedious lab and measurable examinations, which render the contemporary thought of continuous observing disputable. The disturbing results of helpless water quality require an elective strategy, which is speedier and more economical. With this inspiration, this exploration investigates a progression of administered AI calculations to appraise the Water Quality Index (WQI), which acts as a unique attribute to express the generic nature of water. The proposed system utilizes multiple info boundaries, specifically, temperature, pH, dissolved O2 concentration, and all-out broken down molecules. Of the multitude of utilized regression calculations and slope boosting, the water quality index can be expected most productively, with an MSE of 0.27. The propositioned study accomplishes acceptable precision by utilizing a minimum number of features to improve the chances of it getting implemented progressively in water quality recognition frameworks. 2022 IEEE. -
Leveraging machine learning models for intelligent hazard management
[No abstract available] -
Navigating the ethical landscape of artificial intelligence: Challenges, frameworks, and responsible deployment
In artificial intelligence (AI), machine learning (ML) has become a game-changing concept that allows systems to learn from experience and get better without explicit programming. This chapter explores the main ideas, techniques, and applications of ML, offering a succinct introduction to the field. The first step in the process is to gain a basic understanding of supervised learning, which is the process by which algorithms learn to make predictions or judgements from labelled training data. Next, we introduce unsupervised learning, which emphasizes finding patterns in unlabelled data and frequently results in interesting findings and clustering. To emphasize the importance of reinforcement learning in decision-making processes, the paradigm is presented where agents learn by interacting with an environment and receiving feedback. Ideas related to ML, such as feature engineering, model assessment, and the balance between variance and bias, are discussed. The significance of quality data in ML applications is emphasized, along with the impact of data pretreatment on model performance. It also clarifies how neural networks, a branch of ML, simulate the workings of the human brain. The ability of deep learning, a branch of ML that makes use of multi-layered neural networks, to handle challenging tasks such as speech and picture recognition is being investigated. In order to emphasize the necessity of responsible ML model deployment and usage, practical factors are emphasized, including the significance of ethical considerations and responsible AI. The final section of the chapter offers a preview of MLs future, discussing issues and trends that practitioners and researchers should be aware of. This chapter essentially functions as a thorough introduction to ML principles, providing an overview of the wide range of ML approaches, applications, and ethical issues that support the technologys transformative potential across a range of industries. 2025 selection and editorial matter, G. Sucharitha, Anjanna Matta, M. Srinivas and Sachi Nandan Mohanty; individual chapters, the contributors. -
Exploring AI and ML Strategies for Crop Health Monitoring and Management
This chapter offers a thorough examination of machine learning (ML) and artificial intelligence (AI) approaches designed especially for agricultural crop health monitoring. The story starts with a basic introduction to AI and ML ideas and then covers supervised and unsupervised learning approaches, the fundamentals of reinforcement learning, and the significance of high-quality data preparation in agricultural settings. This chapter explores the use of deep learning architectures and neural networks, explaining how they can be used to simulate human brain activity and how they can be used in picture identification to identify crop diseases. A detailed analysis is conducted of the practical aspects of ML for agriculture, encompassing feature engineering and model assessment methodologies. Additionally, the chapter highlights the ethical issues involved in the proper application of AI/ML models in agricultural contexts. These kinds of applications. In conclusion, the chapter discusses obstacles, offers predictions for future developments, and discusses new lines of inquiry for AI and ML research related to crop health monitoring. Through this thorough research, the chapter seeks to offer insightful information on the transformative potential of AI/ML approaches in supporting efficient and sustainable agriculture practices for improved crop health management. (Publisher name) (publishing year) all right reserved. -
Drones for Crop Monitoring and Analysis
Drones are becoming a vital tool for crop monitoring and analysis in contemporary agriculture. With the use of sophisticated sensors, these unmanned aerial vehicles (UAVs) can gather high-resolution pictures and data, giving farmers real-time insights into the growth and health of their crops. Thanks to technological advancements, drones can now more reliably and effectively collect a variety of data points than previous techniques, including plant health, moisture levels, and insect infestations. Drones are a useful tool for crop monitoring because they enable farmers to identify problems early on, such as nutrient deficits, water stress, and disease outbreaks, and take prompt action to optimize yields and avoid losses. Drones can also swiftly and affordably cover vast tracts of agriculture, giving a thorough picture of crop conditions. Farmers may use the information that drones gather to make educated decisions by choices about fertilization plans, pest control techniques, and irrigation schedules, eventually enhancing crop sustainability and output. Drone technology is projected to play an increasingly bigger role in agriculture as it develops, completely changing how farmers monitor and assess their crops. (Publisher name) (publishing year) all right reserved. -
Ant Colony Systems- Enabled Wireless Network Communication
[No abstract available]