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System and method to secure data using substitution box are provided. The method include generating a round key of a pre-defined size of a byte, computing a sum for each value of the round key, applying a mod function on a computed sum with a value equal to the pre-defined size of the byte associated with the round key for generating an index value, computing a dynamic substitution box based on the compound sum and the index value, wherein computing the dynamic substitution box based on the computed sum and the index value comprises computing the dynamic substitution box is equal to an exclusive OR (XOR) operation of inverse of a static substitution box and a byte value of the round key.</text>
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