Teaching through urban sensorium: urban spatiality as a smart learning environment
subject: Emotional intelligence development; Reflective pedagogy; Reflective research; Smart learning; Student self-oriented learning model; Urban sensorium
description: This paper qualitatively analyses the implication of urban sensorium as a pedagogic mode in the teaching of Urban Studies. Underpinned by the frames of smart learning environments, the paper reiterates experiencing urban ontologies as spatial learning environments. By drawing from a range of transdisciplinary and experiential modes of learning, this paper maps how an undergraduate course on Bangalore city in India served learners to critically engage with and experience spatial urban ontologies both digitally, and in real-world experiences of learning, furthering learner autonomy and reflection. The methodological prisms of this paper are autoethnography and critical reflection. It is organised around enabling learners recognize the experiential, embodied urban spaces through the urban sensorium via real-life engagements with urban spaces, and creation of digital portfolios that map this learning. Findings from the learners knowledge of sensory learning, the citys intersectional aspects, and the students embodied and emplaced self in built environments and digital spaces are analysed via cognitive and affective-reflection levels; the course instructor's reflection is analysed via a process-reflection level. These reflections hold implications for the pedagogy of urban studies in undergraduate classrooms by foregrounding spatiality and urban sensorium as significant critical and affective pedagogic tools. The paper has also accommodated critical engagement with an external faculty member as a co-author, in order to manage any bias or researcher subjectivity in the design. 2022, The Author(s).
creator: Jayagopalan G.; Mukherjee S.
source: Smart Learning Environments, Vol-9, No. 1
publisher: Springer
date: 2022-01-01
rights: All Open Access; Gold Open Access
relation: ISSN: 21967091
format: Online
language: English
type: Article
coverage: Jayagopalan G., Department of Language and Literature, Alliance University, Bangalore, India; Mukherjee S., Department of English and Cultural Studies, Christ University, Bangalore Central Campus, Bangalore, India

Are the determinants of foreign direct investment the same within the service sector? Evidence from bootstrap based bias corrected fixed effects model
subject: emerging markets; FDI; service sector
description: Using sectoral as well as subsectoral foreign direct investments (FDI) data, we explore the determinants of FDI in services at both sectoral and sub-sector levels of 25 emerging economies for the period 19992016. We employ a bootstrap-based bias-corrected fixed effects model to analyze whether FDI's determinants vary within the service sector. Our results show that market size, market potential, natural resources endowments, and agglomeration effects are positively associated with the FDI in services and its subsectoral levels. The sectoral disaggregated analysis shows that the variables that attract FDI in services do not vary much from financial to nonfinancial services. This study suggests that there is no need for a separate theory for explaining FDI determinants in financial and nonfinancial services though some modifications are to be made. Before making modifications, we have to consider the salient features of service sector FDI, such as intangibility, inseparability, perishability, heterogeneity, and commercial presence. 2021 John Wiley & Sons Ltd.
creator: Jithin P.; Sureshbabu M.
source: Journal of Public Affairs, Vol-22, No. S1
publisher: John Wiley and Sons Ltd
date: 2022-01-01
rights: Restricted Access
relation: ISSN: 14723891
format: Online
language: English
type: Article
coverage: Jithin P., Department of Economics, Christ University, Bangalore, India; Sureshbabu M., Department of Humanities and Social Sciences, Indian Institute of Technology Madras, Chennai, India

Performance investigation of modular multilevel inverter topologies for photovoltaic applications with minimal switches
subject: fast Fourier transform; multilevel inverter; photovoltaic; pulse width modulation techniques; total harmonic distortion
description: Introduction. In recent years, a growing variety of technical applications have necessitated the employment of more powerful equipment. Power electronics and megawatt power levels are required in far too many medium voltage motor drives and utility applications. It is challenging to incorporate a medium voltage grid with only one power semiconductor that has been extensively modified. As a result, in high power and medium voltage settings, multiple power converter structure has been offered as a solution. A multilevel converter has high power ratings while also allowing for the utilization of renewable energy sources. Renewable energy sources such as photovoltaic, wind, and fuel cells may be readily connected to a multilevel inverter topology for enhanced outcomes. The novelty of the proposed work consists of a novel modular inverter structure for solar applications that uses fewer switches. Purpose. The proposed architecture is to decrease the number of switches and Total Harmonic Distortions. There is no need for passive filters, and the proposed design enhances power quality by creating distortion-free sinusoidal output voltage as the level count grows while also lowering power losses. Methods. The proposed topology is implemented with MATLAB / Simulink, using gating pulses and various pulse width modulation methodologies. Moreover, the proposed model also has been validated and compared to the hardware system. Results. Total harmonic distortion, number of power switches, output voltage and number of DC sources are compared with conventional topologies. Practical value. The proposed topology has been very supportive for implementing photovoltaic based multilevel inverter, which is connected to large demand in grid. References 12, table 5, figures 23. E. Parimalasundar, N.M.G. Kumar, P. Geetha, K. Suresh.
creator: Parimalasundar E.; Kumar N.M.G.; Geetha P.; Suresh K.
source: Electrical Engineering and Electromechanics, Vol-2022, No. 6, pp. 28-34.
publisher: National Technical University "Kharkiv Polytechnic Institute"
date: 2022-01-01
rights: All Open Access; Gold Open Access; Green Open Access
relation: ISSN: 2074272X
format: Online
language: English
type: Article
coverage: Parimalasundar E., Department of Electrical & Electronics Engineering, Sree Vidyanikethan Engineering College, AP, Tirupati, 517102, India; Kumar N.M.G., Department of Electrical & Electronics Engineering, Sree Vidyanikethan Engineering College, AP, Tirupati, 517102, India; Geetha P., Department of Electronics and Communication Engineering, Sree Vidyanikethan Engineering College, AP, Tirupati, 517102, India; Suresh K., Department of Electrical and Electronics Engineering, Christ (Deemed to be University), Bangalore, India

Transparency in governance: A comparative study of right-to-information legislation in India, Indonesia and Nigeria
subject: accountability; corruption; disclosure; government; India; Indonesia; Nigeria; Right to Information Act; transparency
description: This article discusses how the Right to Information Act in India, Nigeria and Indonesia can have an influence on ensuring transparency and accountability in the government system. The acts pertaining to the right to information in these three countries were implemented after long proceedings and deep struggles. The article looks at the legislation on the right to information in these three countries, the factors that motivated each of them to adopt the legislation, the implementation of the Right to Information Act, the challenges faced during the passage of the Act, the scope of coverage of the provisions of the Acts of all three countries, exceptions to the information disclosed to the public and problems faced during implementation from the government's side and the user's side. The article concludes with a summary of the arguments and key policy recommendations. The Author(s) 2022.
creator: Kaur H.
source: Asian Journal of Comparative Politics, Vol-7, No. 4, pp. 1282-1296.
publisher: SAGE Publications Ltd
date: 2022-01-01
rights: Restricted Access
relation: ISSN: 20578911
format: Online
language: English
type: Article
coverage: Kaur H., Christ University, India

SarNet-1 -A Novel Architecture for Diagnosing Covid-19 Pneumonia and Pneumonia through Chest X-Ray Images
subject: Deep learning, Convolutional Neural Network(CNN). Chest X-ray images (CXR) Pneumonia detection COVID-19
description: Coronavirus (COVID-19) is a contagious disease which begins with flu-like symptoms. COVID-19 arose in China and it rapidly spread throughout the globe, leading to a pandemic. For many, it was noticed that the infection started with fever, cough and finally leading to pneumonia. It is very necessary to differentiate between covid pneumonia and general pneumonia for appropriate treatment. Chest X-ray readings are useful for radiologists to identify the severity of infection. While computerising this mechanism, deep learning techniques are found to be very useful in extracting relevant features from medical images. This can help in differentiating pneumonia, COVID19 pneumonia and x-rays of a healthy person. Computer aided methods for identifying the presence of pneumonia can help health providers to a great extent for quick diagnosis. The X-rays gathered from freely available datasets are used in this work to propose an architecture for categorising X-rays into pneumonia and covid pneumonia. 2022 International Journal on Recent and Innovation Trends in Computing and Communication. All rights reserved.
creator: Unnisa S.; Vijayalakshmi A.
source: International Journal on Recent and Innovation Trends in Computing and Communication, Vol-10, No. 1, pp. 1-7.
publisher: Auricle Global Society of Education and Research
date: 2022-01-01
rights: All Open Access; Gold Open Access
relation: ISSN: 23218169
format: Online
language: English
type: Article
coverage: Unnisa S., Department of Computer Science, CHRIST Deemed to be University, Bangalore, India; Vijayalakshmi A., Department of Computer Science, CHRIST Deemed to be University, Bangalore, India

Translation and validation of the Tamil version of depression anxiety stress scales-21
subject: DASS-21; Depression; Invariance; Translation; Validation
description: The Depression Anxiety Stress Scales-21 (DASS-21) is a well-established scale designed to measure the negative emotional states of depression, anxiety, and stress. DASS-21 has been translated into various languages, and findings conclude that it is psychometrically sound, with good reliability and validity. This study adapts and validates the psychometric properties of DASS-21 in the Tamil language. The instrument was administered to 511 Tamil speaking students ranging between 18 and 35 of age with an average age of 21 years. Results reaffirm that DASS-21 three-factor model shows excellent validity and reliability on the entire sample and groups based on age, gender, and residential area. They also find support in different hierarchical variance measurement models (metric, scalar, strict models). This study concludes that Tamil DASS-21 can be used as a universal measure to map symptoms and screen for depression, anxiety, and stress in any circumstances. Our findings provide roadmap for future research on the Tamil version of DASS-21 with specific focus on its clinical use. 2022
creator: Alagarsamy S.; Sugirthan N.; Mehrolia S.; Elangovan N.
source: Journal of Affective Disorders Reports, Vol-10
publisher: Elsevier B.V.
date: 2022-01-01
rights: All Open Access; Gold Open Access
relation: ISSN: 26669153
format: Online
language: English
type: Article
coverage: Alagarsamy S., School of Business, Manipal Academy of Higher Education, Dubai Campus, United Arab Emirates; Sugirthan N., Royal Australian College of General Practitioners, Bridgeview Medical Practice, Toongabbie, NSW, Australia; Mehrolia S., School of Business and Management, Christ University, Bangalore, India; Elangovan N., School of Business and Management, Christ University, Bangalore, India

Fluorescent detection of Pb2+ pollutant in water samples with the help of Delonix regia leaf-derived CQDs
subject: Carbon quantum dots; Delonix regia leaves; FRET; Hydrothermal synthesis; Pb2+ ions
description: Heavy metals released from different sources into water bodies are a major concern in the view of environmental protection. Their non-biodegradability and the numerous health hazards add to the issue. Scientists worldwide have emphasized the issue and are trying to resolve it by different means. Among all the methods, the fluorescent method stands out for its simplicity and rapid results. Here, the study focuses on the development of an efficient and sustainable method for the detection of lead in waste-water effluents. Carbon quantum dots (GCDs), a highly non-toxic substance developed from Delonix regia leaves for the purpose via a simple hydrothermal method. The prepared GCDs exhibited good photostability and water solubility; they also displayed a bright red emission when irradiated with ultraviolet (UV) light. Here, the authors propose the synthesized GCDs as an effective fluorescent probe for sensitive detection of lead ions in aqueous samples. Photoluminescence quenching of GCDs by the addition of lead was studied and a good detection limit of 3.3 nM with a linear range of 10180 M was achieved. Further, real sample analysis was also conducted to prove the applicability of the synthesized GCDs. 2022 Elsevier B.V.
creator: Babu A.M.; Bijoy G.; Keerthana P.; Varghese A.
source: Synthetic Metals, Vol-291
publisher: Elsevier Ltd
date: 2022-01-01
rights: Restricted Access
relation: ISSN: 3796779; CODEN: SYMED
format: Online
language: English
type: Article
coverage: Babu A.M., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bangalore, 560029, India; Bijoy G., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bangalore, 560029, India; Keerthana P., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bangalore, 560029, India; Varghese A., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bangalore, 560029, India

Active galactic nucleus feedback in NGC 3982
subject: Galaxies: Active; Galaxies: individual: NGC 3982; Galaxies: star formation; Ultraviolet: galaxies
description: The energetic feedback from supermassive black holes can influence star formation at the centres of galaxies. Observational evidence for active galactic nucleus (AGN) impact on star formation can be searched for in galaxies by combining ultraviolet imaging and optical integral field unit data. The ultraviolet flux directly traces recent star formation, and the integral field unit data can reveal dust attenuation, gas ionisation mechanisms, and gas kinematics from the central regions of the galaxy disk. A pilot study on NGC 3982 shows star formation suppression in the central regions of the galaxy, likely due to negative AGN feedback, and enhanced star formation in the outer regions. The case of NGC 3982 could be observational evidence of AGN feedback operating in a Seyfert galaxy. 2022 EDP Sciences. All rights reserved.
creator: Joseph P.; George K.; Paul K.T.
source: Astronomy and Astrophysics, Vol-667
publisher: EDP Sciences
date: 2022-01-01
rights: All Open Access; Green Open Access; Hybrid Gold Open Access
relation: ISSN: 46361; CODEN: AAEJA
format: Online
language: English
type: Article
coverage: Joseph P., Department of Physics, CHRIST University, Bangalore, 560029, India, Indian Institute of Astrophysics, Bangalore, 560034, India; George K., Faculty of Physics, Ludwig-Maximilians-Universit, Scheinerstr. 1, Munich, 81679, Germany; Paul K.T., Department of Physics, CHRIST University, Bangalore, 560029, India

The mediating role of parental playfulness on parentchild relationship and competence among parents of children with ASD
subject: Autism spectrum disorder; Child; Parental competence; Parentchild relationship; Playfulness
description: Purpose: The difficulties of a child diagnosed with autism spectrum disorder (ASD) can lead to behaviours that are quite challenging for parents to understand and address. Most of the parental studies of ASD focus on the challenges faced by the parents. This study aims to adopt a strength-based model that investigates the mediating role of parental playfulness in the association between parentchild relationship and parental competence. Design/methodology/approach: This study is a quantitative study that adopts a correlational research design. The mediation analysis explores the role of parental playfulness as a mediator in the association between parentchild relationship and parental competence. The sample consisted of 120 parents of children diagnosed with ASD from India, selected using a purposive sampling technique. Findings: The mediation analysis results indicate that playfulness among parents of children with ASD was found to function as a partial mediator in the relationship between parentchild relationship and parental competence. This could suggest that more playful parents have better parentchild relationships and are competent in parenting. Research limitations/implications: These findings have importance in understanding the role of playful interaction on parentchild relationships and parenting competence, having implications for further research. Enabling playfulness in parenting will enhance children and parents to promote their relationship and thus feel competent to bring positive light in their lives. Practical implications: Most often, the clinicians are concerned with addressing only the autistic symptoms; it is also essential to look into parental well-being. Practical playful interaction training should help parents establish a rapport, understand, adjust and adapt with their child. Social implications: Practical intervention and training plans can be suggested to all family members to improve the condition of the child and the familys general w…
creator: Roy R.G.; Kumar A.
source: Advances in Autism, Vol-8, No. 4, pp. 306-318.
publisher: Emerald Publishing
date: 2022-01-01
rights: Restricted Access
relation: ISSN: 20563868
format: Online
language: English
type: Article
coverage: Roy R.G., Rini Grace Roy and Aneesh Kumar are both based at the Department of Psychology, Christ University, Bangalore, India; Kumar A., Rini Grace Roy and Aneesh Kumar are both based at the Department of Psychology, Christ University, Bangalore, India

Understanding the secular evolution of NGC 628 using UltraViolet Imaging Telescope
subject: galaxies: evolution; galaxies: spiral; galaxies: star formation
description: Secular and environmental effects play a significant role in regulating the star-formation rate and hence the evolution of the galaxies. Since ultraviolet (UV) flux is a direct tracer of the star formation in galaxies, the UltraViolet Imaging Telescope (UVIT) onboard AstroSat enables us to characterize the star-forming regions in a galaxy with its remarkable spatial resolution. In this study, we focus on the secular evolution of NGC 628, a spiral galaxy in the local Universe. We exploit the resolution of UVIT to resolve up to ?63 pc in NGC 628 for identification and characterization of the star-forming regions. We identify 300 star-forming regions in the UVIT far-UV image of NGC 628 using ProFound and the identified regions are characterized using Starburst99 models. The age and mass distribution of the star-forming regions across the galaxy supports the inside-out growth of the disc. We find that there is no significant difference in the star-formation properties between the two arms of NGC 628. We also quantify the azimuthal offset of the star-forming regions of different ages. Since we do not find an age gradient, we suggest that the spiral density waves might not be the possible formation scenario of the spiral arms of NGC 628. The headlight cloud present in the disc of the galaxy is found to be having the highest star-formation rate density (0.23 Myr-1 kpc-2) compared to other star-forming regions on spiral arms and the rest of the galaxy. 2022 The Author(s) Published by Oxford University Press on behalf of Royal Astronomical Society.
creator: Ujjwal K.; Kartha S.S.; Subramanian S.; George K.; Thomas R.; Mathew B.
source: Monthly Notices of the Royal Astronomical Society, Vol-516, No. 2, pp. 2171-2180.
publisher: Oxford University Press
date: 2022-01-01
rights: All Open Access; Green Open Access
relation: ISSN: 358711; CODEN: MNRAA
format: Online
language: English
type: Article
coverage: Ujjwal K., Department of Physics and Electronics, CHRIST (Deemed to Be University), Bangalore, 560029, India; Kartha S.S., Department of Physics and Electronics, CHRIST (Deemed to Be University), Bangalore, 560029, India; Subramanian S., Indian Institute of Astrophysics, Sarjapur Road, Koramangala, Bangalore, 560034, India; George K., Faculty of Physics, Ludwig-Maximilians-Universit, Scheinerstr 1, Munich, D-81679, Germany; Thomas R., Department of Physics and Electronics, CHRIST (Deemed to Be University), Bangalore, 560029, India; Mathew B., Department of Physics and Electronics, CHRIST (Deemed to Be University), Bangalore, 560029, India

Implementation and Investigation of an Optimal Full Adder Design for Low Power and Reduced Delay Conditions
subject: Capacitance; Digital Signal Processing (DSP); Full adder; Power Delay Product (PDP); Transistor; Very Large-Scale Integration (VLSI)
description: Full adder is one of the important components in electronics, used for various fundamental processing algorithms such as addition and multiplication. The application of these full adders is included in but not limited to Very Large-Scale Integration (VLSI) and Digital Signal Processing (DSP). To provide scalability and reliability to the advanced algorithms for high-end applications, the designing system of full adder should be enhanced. So, in this paper, we intended to improve the efficiency of a full adder circuit to work under low power and delay conditions. The software we used in this project is MENTOR GRAPHICS using 180nm technology. The efficiency of the proposed transistor design is evaluated by analysing the power consumption, delay, PDP, capacitor load, delay w.r.t capacitance and PDP w.r.t capacitance. The parameters are compared between our proposed design and the literature schemes such as OLPFAD, DFEFA, DTLPCFA, and DPEHFA, respectively. It is evident that our proposed design outperforms the other. 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
creator: Praghash K.; Arun Metha S.; Sai Tanuja B.; Preethi K.; Chandana N.P.N.S.
source: Wireless Personal Communications, Vol-126, No. 4, pp. 3041-3069.
publisher: Springer
date: 2022-01-01
rights: Restricted Access
relation: ISSN: 9296212; CODEN: WPCOF
format: Online
language: English
type: Article
coverage: Praghash K., Department of Electronics and Communication Engineering, Christ University, Karnataka, Bengaluru, India; Arun Metha S., Department of Electronics and Communication Engineering, Koneru Lakshmaiah Education Foundation, AP, Vaddeswaram, India; Sai Tanuja B., Department of Electronics and Communication Engineering, Koneru Lakshmaiah Education Foundation, AP, Vaddeswaram, India; Preethi K., Department of Electronics and Communication Engineering, Koneru Lakshmaiah Education Foundation, AP, Vaddeswaram, India; Chandana N.P.N.S., Department of Electronics and Communication Engineering, Koneru Lakshmaiah Education Foundation, AP, Vaddeswaram, India

Studies on the characterisation of thiophene substituted 1,3,4-oxadiazole derivative for the highly selective and sensitive detection of picric acid
subject: 1,3,4-oxadiazole; Binding constant; Fluorescence quenching; Nitrated explosives or nitroaromatic compounds; Picric acid
description: A novel thiophene substituted 1,3,4-oxadiazole based chemosensor namely 2-(4-(5-(5-hexylthiophen-2-yl) thiophen-2-yl)phenyl) -5-(5-(5-(5-hexylthiophen-2-yl) thiophen-2-yl)thiophen-2-yl)-1,3,4-oxadiazole [TKO] has been characterised for the efficient detection of picric acid (PA) based on fluorescence quenching mechanism. In this regard, the electronic absorption spectra, fluorescence spectra, and fluorescence lifetime of TKO are recorded in the presence of different nitroaromatic compounds (NACs) in ethanol at room temperature. The absorption studies exhibited a blue shift in the absorption maxima with the increase in the concentration of PA. In the fluorescence titration studies, TKO shows a remarkable fluorescence quenching with picric acid as compared to other nitroaromatic compounds. Using the Benesi-Hildebrand plot, the binding constant value of PA with TKO is determined and is of the order of 6.467 104 M?1. Job's plot analysis confirms the 1:1 binding stoichiometry ratio between TKO and PA and is supported by the 1H NMR studies. The detection limit is determined and is of the order of 10.08 M. The competitive studies revealed that TKO is highly selective for recognizing PA without the interference of other NACs. The theoretical studies were also carried out to understand the binding mechanisms of PA with TKO. The fluorescence quenching of TKO by PA may be attributed to photo induced electron transfer (PET). Overall, the experimental findings suggest that, the novel probe TKO may be used as a highly selective and sensitive chemosensor for the detection of explosives like picric acid. 2022 Elsevier B.V.
creator: Thippeswamy M.S.; Naik L.; Maridevarmath C.V.; Savanur H.M.; Malimath G.H.
source: Journal of Molecular Structure, Vol-1264
publisher: Elsevier B.V.
date: 2022-01-01
rights: Restricted Access
relation: ISSN: 222860; CODEN: JMOSB
format: Online
language: English
type: Article
coverage: Thippeswamy M.S., UG and PG Department of Physics, Karnatak Science College, Karnataka, Dharwad, 580001, India; Naik L., Department of Physics and Electronics, CHRIST (Deemed to be University), Bangalore Central Campus, Karnataka, Bengaluru, 560029, India; Maridevarmath C.V., Department of Physics, Government First Grade College, Karnataka, Hubballi, 580032, India; Savanur H.M., Department of Chemistry, P.C. Jabin, Science College, Karnataka, Hubballi, India; Malimath G.H., UG and PG Department of Physics, Karnatak Science College, Karnataka, Dharwad, 580001, India

Aging, sexual intimacy, and challenges in contemporary India: A qualitative study
subject: age norm; aging; family support; sexual intimacy; social change; social norm
description: An individual's life is shaped by age norms practiced in a particular society. In most societies, there is a deadline for every life event. Sexual intimacy is an essential part of every individual. However, sexual intimacy seems appropriate for young individuals, and middle-aged and older are considered asexual. Those who share sexual intimacy at a later age have to face the consequences for this age-inappropriate behavior in society. This study analyses Badhaai Ho film to explore the consequences of sharing sexual intimacy by middle-aged heterosexual couples in their 50s as it is forbidden by prevalent social norms. This study also explores the role of family in dealing with the repercussions of actions against the prescribed social norms. Thematic analysis suggests that society has a predefined age-bound box for individuals with different age categories. The middle-aged couple suffers various consequences for breaking the prescribed age-bound box. The role of the family is found to be crucial in mending the box by replacing it with an updated version. There are also gender differences in attitude toward sexual intimacy. Implications of this study can be utilized to explore the pathway of social change in existing social (age) norms in any society. Copyright 2022 Srivastava and Upadhaya.
creator: Srivastava S.; Upadhaya P.
source: Frontiers in Psychology, Vol-13
publisher: Frontiers Media S.A.
date: 2022-01-01
rights: All Open Access; Gold Open Access; Green Open Access
relation: ISSN: 16641078
format: Online
language: English
type: Article
coverage: Srivastava S., CHRIST (Deemed to Be) University, NCR, Ghaziabad, Delhi, India; Upadhaya P., School of Gender and Development Studies, Indira Gandhi National Open University, New Delhi, India

In Silico Analysis of the Apoptotic and HPV Inhibitory Roles of Some Selected Phytochemicals Detected from the Rhizomes of Greater Cardamom
subject: Apoptosis; Docking; HPV; In silico analysis; Large cardamom; Phytochemicals
description: Occurrence of cervical cancer, caused due to persistent human papilloma virus (HPV) infection, is common in women of developing countries. As the conventional treatments are expensive and associated with severe side effects, there is a need to find safer alternatives, which is affordable and less toxic to the healthy human cells. Present study aimed to evaluate the anti-HPV and apoptotic potential of four compounds from the greater cardamom (Amomum subulatum Roxb. var. Golsey), namely rhein, phytosphingosine, n-hexadecenoic acid and coronarin E. Their anti-HPV and apoptotic potential were studied against viral E6, E7 and few anti-apoptotic proteins of host cell (BCL2, XIAP, LIVIN) by in silico docking technique. Phytochemicals from the plant extract were analysed and identified by LC/MS and GC/MS. Involvement of the target proteins in various biological pathways was determined through KEGG. Structural optimization of the three-dimensional structures of the ligands (four phytochemicals and control drug) was done by Avogadro1.1. Receptor protein models were built using ProMod3 and other advanced tools. Pharmacophore modelling of the selected phytochemicals was performed in ZINCPharmer. Swiss ADME studies were undertaken to determine drug likeness. The ligands and proteins were digitally docked in DockThor docking program. Protein flexibility-molecular dynamic simulation helped to study proteinligand stability in real time. Finally, the correlation of evaluated molecules was studied by the use of principal component analysis (PCA) based on the docking scores. All the ligands were found to possess apoptotic and anti-cancer activities and did not violate Lipinsky criteria. n-Hexadecanoic acid and its analogues showed maximum efficacy against the target proteins. All the proteinligand interactions were found to be stable. The uncommon phytochemicals identified from rhizomes of greater cardamom have anti-cancer, apoptotic and HPV inhibitory potentials as analysed by dockin…
creator: Nag A.; Verma P.; Paul S.; Kundu R.
source: Applied Biochemistry and Biotechnology, Vol-194, No. 10, pp. 4867-4891.
publisher: Springer
date: 2022-01-01
rights: All Open Access; Bronze Open Access; Green Open Access
relation: ISSN: 2732289; PubMed ID: 35670907
format: Online
language: English
type: Article
coverage: Nag A., Department of Life Sciences, CHRIST (Deemed to Be University), Bangalore, India; Verma P., Laboratory of Advanced Cell Biology, Department of Botany, University of Calcutta, 35 Ballygunge Circular Road, West Bengal, Kolkata, 700019, India; Paul S., Institute of Health Sciences, Presidency University, 2Nd Campus, Kolkata, Newtown, India; Kundu R., Laboratory of Advanced Cell Biology, Department of Botany, University of Calcutta, 35 Ballygunge Circular Road, West Bengal, Kolkata, 700019, India

DeepBBBP: High Accuracy Blood-brain-barrier Permeability Prediction with a Mixed Deep Learning Model
subject: Blood-brain-barrier; Convolutional Neural Network; Deep Learning; Drug design; Mol2vec; Multi-layer Perceptron
description: Blood-brain-barrier permeability (BBBP) is an important property that is used to establish the drug-likeness of a molecule, as it establishes whether the molecule can cross the BBB when desired. It also eliminates those molecules which are not supposed to cross the barrier, as doing so would lead to toxicity. BBBP can be measured in vivo, in vitro or in silico. With the advent and subsequent rise of in silico methods for virtual drug screening, quite a bit of work has been done to predict this feature using statistical machine learning (ML) and deep learning (DL) based methods. In this work a mixed DL-based model, consisting of a Multi-layer Perceptron (MLP) and Convolutional Neural Network layers, has been paired with Mol2vec. Mol2vec is a convenient and unsupervised machine learning technique which produces high-dimensional vector representations of molecules and its molecular substructures. These succinct vector representations are utilized as inputs to the mixed DL model that is used for BBBP predictions. Several well-known benchmarks incorporating BBBP data have been used for supervised training and prediction by our mixed DL model which demonstrates superior results when compared to existing ML and DL techniques used for predicting BBBP. 2022 Wiley-VCH GmbH.
creator: Cherian Parakkal S.; Datta R.; Das D.
source: Molecular Informatics, Vol-41, No. 10
publisher: John Wiley and Sons Inc
date: 2022-01-01
rights: Restricted Access
relation: ISSN: 18681743; PubMed ID: 35393777; CODEN: MIONB
format: Online
language: English
type: Article
coverage: Cherian Parakkal S., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Bengaluru, 560029, India; Datta R., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Bengaluru, 560029, India; Das D., Intel, Bengaluru, 560103, India

Combined effect of channel to rib width ratio and gas diffusion layer deformation on high temperature Polymer electrolyte membrane fuel cell performance
subject: Clamping pressure; Contact resistance; Fuel cell; GDL deformation; Numerical modeling
description: The present study investigates the combined influence of Channel to Rib Width (CRW) ratio and clamping pressure on the structure and performance of High Temperature-Polymer Electrolyte Membrane Fuel Cell (HT-PEMFC) using a three-dimensional numerical model developed previously. It also considers the impact of interfacial contact resistance between the Gas Diffusion Layer (GDL) and Bipolar Plate (BPP). The structural analysis of the single straight channel HT-PEMFC geometry shows that the von-Mises stress greatly increases in the GDL under the ribs as the CRW ratio increases resulting in considerably high deformation. The cell performance analysis depicts the significance of ohmic resistance and concentration polarization for different CRW ratios, particularly at higher operating current densities. However, in low to medium current density regions, the CRW ratio has little influence on cell performance. A substantial impact on the species, overpotential, and current distributions is observed. The findings also reveal that the CRW ratio significantly affects the temperature distribution in the cell. 2022 Hydrogen Energy Publications LLC
creator: Varghese G.; K. P V.B.; Joseph T.V.; Chippar P.
source: International Journal of Hydrogen Energy, Vol-47, No. 77, pp. 33014-33026.
publisher: Elsevier Ltd
date: 2022-01-01
rights: Restricted Access
relation: ISSN: 3603199; CODEN: IJHED
format: Online
language: English
type: Article
coverage: Varghese G., CHRIST (Deemed to be University), Bengaluru, 560 029, India; K. P V.B., CHRIST (Deemed to be University), Bengaluru, 560 029, India; Joseph T.V., CHRIST (Deemed to be University), Bengaluru, 560 029, India; Chippar P., Applied Engineering and Computational Analysis Laboratory, St Joseph Engineering College (Affiliated to Visvesvaraya Technological University, Belagavi), Vamanjoor, Mangaluru, 575 028, India

A Novel Survey for Young Substellar Objects with the W-band Filter. V. IC 348 and Barnard 5 in the Perseus Cloud
description: We report the discovery of substellar objects in the young star cluster IC 348 and the neighboring Barnard 5 dark cloud, both at the eastern end of the Perseus star-forming complex. The substellar candidates are selected using narrowband imaging, i.e., on and off photometric technique with a filter centered around the water absorption feature at 1.45 ?m, a technique proven to be efficient in detecting water-bearing substellar objects. Our spectroscopic observations confirm three brown dwarfs in IC 348. In addition, the source WBIS 03492858+3258064, reported in this work, is the first confirmed brown dwarf discovered toward Barnard 5. Together with the young stellar population selected via near- and mid-infrared colors using the Two Micron All Sky Survey and the Wide-field Infrared Survey Explorer, we diagnose the relation between stellar versus substellar objects with the associated molecular clouds. Analyzed by Gaia EDR3 parallaxes and kinematics of the cloud members across the Perseus region, we propose the star formation scenario of the complex under influence of the nearby OB association. 2022. The Author(s). Published by the American Astronomical Society.
creator: Lalchand B.; Chen W.-P.; Biller B.A.; Albert L.; Allers K.; Dubber S.; Zhang Z.; Liu M.C.; Jose J.; Damian B.; Sharma T.; Bonnefoy M.; Oasa Y.
source: Astronomical Journal, Vol-164, No. 4
publisher: American Astronomical Society
date: 2022-01-01
rights: All Open Access; Gold Open Access; Green Open Access
relation: ISSN: 46256
format: Online
language: English
type: Article
coverage: Lalchand B., Institute of Astronomy, National Central University, 300 Zhongda Road, Zhongli, Taoyuan, 32001, Taiwan; Chen W.-P., Institute of Astronomy, National Central University, 300 Zhongda Road, Zhongli, Taoyuan, 32001, Taiwan, Department of Physics, National Central University, 300 Zhongda Road, Zhongli, Taoyuan, 32001, Taiwan; Biller B.A., SUPA, Institute for Astronomy, University of Edinburgh, Blackford Hill, Edinburgh, EH9 3HJ, United Kingdom, Centre for Exoplanet Science, University of Edinburgh, Edinburgh, United Kingdom; Albert L., Institut de Recherche sur les Exoplanes (IREx), Universitde Montrl, Dartement de Physique, C.P. 6128 Succ. Centre-ville, Montrl, H3C 3J7, QC, Canada; Allers K., Department of Physics and Astronomy, Bucknell University, Lewisburg, 17837, PA, United States; Dubber S., SUPA, Institute for Astronomy, University of Edinburgh, Blackford Hill, Edinburgh, EH9 3HJ, United Kingdom, Centre for Exoplanet Science, University of Edinburgh, Edinburgh, United Kingdom; Zhang Z., The University of Texas at Austin, Department of Astronomy, C1400, 2515 Speedway, Austin, 78712, TX, United States; Liu M.C., Institute for Astronomy, University of Hawai'i, 2680 Woodlawn Drive, Honolulu, 96822, HI, United States; Jose J., Indian Institute of Science Education and Research (IISER) Tirupati, Rami Reddy Nagar, Karakambadi Road, Mangalam (P.O.), Tirupati, 517 507, India; Damian B., CHRIST (Deemed to Be University), Hosur Road, Bengaluru, 560029, India; Sharma T., Institute of Astronomy, National Central University, 300 Zhongda Road, Zhongli, Taoyuan, 32001, Taiwan; Bonnefoy M., Univ. Grenoble Alpes, CNRS, IPAG, Grenoble, F-38000, France; Oasa Y., Faculty of Education, Graduate School of Science and Engineering, Saitama University, 255 Shimo-Okubo, Sakura-ku, Saitama, 338-8570, Japan

A mathematical model that describes the relation of low-density lipoprotein and oxygen concentrations in a stenosed artery
subject: Endothelium; Finite element method; Hypoxia; Recirculation; Wall shear stress
description: The cellular activities of the endothelium layer between lumen and intima are significantly linked to the origin of the disease atherosclerosis. Three stages of atherosclerosis were investigated in this study (40%-mild, 50%-modest, and 60%-acute) concerning the coronary arterial segment. The essence of the hemodynamic factors like flow velocity, pressure, and wall shear stress has been investigated, as well as the interrelationships between them. At all degrees of stenosis, the biophysical relationship between convection-diffusion of low-density lipoproteins (LDL) and convection-diffusion of oxygen in the bloodstream is investigated. The Finite Element Methods (FEM) are used to solve the modeled partial differential equation systems. The method adopted is numerical in nature providing accurate graphical solutions to the framed systems. The physical effects of the deposition of LDL on the arterial wall, like a decrease in the diameter of the lumen, and toughening of the walls, are analyzed through the evaluation of the physical parameters. The study revealed that the deposition of LDL molecules in the post stenotic region leads to the depletion of oxygen in the region leading to the rapid dysfunctioning of the endothelial layer of the lumen-intima boundary. 2022 World Scientific Publishing Company.
creator: Shankar Narayan S.; Anuradha B.; Sunanda S.; Puneeth V.; Ijaz Khan M.; Abdullah A.; Guedri K.; Jameel M.
source: International Journal of Modern Physics B, Vol-36, No. 26
publisher: World Scientific
date: 2022-01-01
rights: Restricted Access
relation: ISSN: 2179792; CODEN: IJPBE
format: Online
language: English
type: Article
coverage: Shankar Narayan S., Department of Mathematics, Cmr Institute of Technology, Bangalore, 560 037, India, Department of Mathematics, Dayananda Sagar University, Bangalore, 560 114, India; Anuradha B., Department of Mathematics, Dayananda Sagar University, Bangalore, 560 114, India; Sunanda S., Department of Mathematics, Vellore Institute of Technology, Vellore, 632 014, India; Puneeth V., Department of Mathematics, Christ (Deemed to Be University), Bangalore, 560 029, India; Ijaz Khan M., Department of Mathematics and Statistics, Ripah International University I-14, Islamabad, 44000, Pakistan, Mathematical Modelling and Applied Computation Research Group (MMAC), Department of Mathematics, King Abdulaziz University, Jeddah, Saudi Arabia; Abdullah A., Department of Mathematics, Taif University, Taif, 21944, Saudi Arabia; Guedri K., Mechanical Engineering Department, College of Engineering and Islamic Architecture, Umm Al-Qura University, P.O. Box 5555, Makkah, 21955, Saudi Arabia; Jameel M., Department of Civil Engineering, College of Engineering, King Khalid University, Asir, P.O. Box 960, Abha, 61421, Saudi Arabia

Statistical features learning to predict the crop yield in regional areas
subject: Classification; Clustering; Computer science; Machine learning; Statistical features
description: The plethora of information presented in the form of benchmark dataset plays a significant role in analyzing and understanding the crop yield in certain regions of regional territory. The information may be presented in the form of attributes makes a prediction of crop yield in various regions of machine learning. The information considered for processing involves data cleaning initially followed by binning to reduce the missing data. The information collected is subjected to clustering of data items based on patterns of similarity, The data items that are similar in nature is fed to the system with similarity measure, which involves understanding the distance of data items from its related data item leading to hyper parameters for analyzing of information while calculating the crop yield. The information may be used to ascertain the patterns of data that exhibit similarity with nearest neighbor represented by another attribute. Thus, the research method has yielded an accuracy of 89.62% of classification for predicting the crop yield in agricultural areas of Karnataka region. 2022 Institute of Advanced Engineering and Science. All rights reserved.
creator: Ramanahalli P.P.; Siddamallu H.K.; Basavaraju R.K.Y.
source: International Journal of Electrical and Computer Engineering, Vol-12, No. 5, pp. 5321-5329.
publisher: Institute of Advanced Engineering and Science
date: 2022-01-01
rights: All Open Access; Gold Open Access; Green Open Access
relation: ISSN: 20888708
format: Online
language: English
type: Article
coverage: Ramanahalli P.P., School and Computer Science and Applications, REVA University, Bangalore, India; Siddamallu H.K., School of Computer Science and Applications, REVA University, Bangalore, India; Basavaraju R.K.Y., Department of Computer Science and Engineering, Christ (Deemed to be University), Bangalore, India

Travel time activities Mobility and femininities in the ladies compartments of the Mumbai local trains
subject: gender; mobility; space; trains; travel; women
description: Activities undertaken during everyday commutes have often been studied to prove the inherent value of travel time to the commuters. Women commuters using the ladies compartments of the Mumbai local trains use this time to eat and share food, shop, chitchat, and watch sitcoms on their phones. Undertaken in a gender-segregated space, these activities make womens mobility an avenue for the performance of their femininities. Thus, while the association between masculinity and mobility stands questioned, what merits enquiry is whether mobility for women is premised on their effective performance of hegemonic femininities. 2022 The Society for Ethnographic Theory. All rights reserved.
creator: Arundhathi
source: HAU: Journal of Ethnographic Theory, Vol-12, No. 2, pp. 565-579.
publisher: University of Chicago Press
date: 2022-01-01
rights: Restricted Access
relation: ISSN: 25751433
format: Online
language: English
type: Article
coverage: Arundhathi, Christ University, Bangalore, India