Nanocellulose from coconut midrib used for antibacterial and electromagnetic interference shielding applications
Midrib of coconut (Cocos nucifera) is a natural source of cellulose, which is renewable and biodegradable. The use of natural cellulose for practical applications exemplifies a sustainable reuse of agricultural waste. This work presents the preparation of nanocellulose from coconut midrib using optimized pretreatment and acid hydrolysis processes. The resulting nanocellulose was characterized through various analyses to confirm the morphology and composition. Nanocellulose thus synthesized was used for preparing cellulose nanopaper. In order to improve the water resistance of the cellulose nanopaper, we used a simple approach of functionalization by impregnating it with chitosan (CS), followed by in situ polymerization of polypyrrole (PPy) in the matrix. The functionalized cellulose nanopaper shows good electrical conductivity and an electromagnetic interference (EMI) shielding effectiveness of 21.92 dB at 10 GHz, which makes it a potential material for EMI shielding applications. In addition, the functionalized cellulose nanopaper exhibits bacterial reductions of 93.47% and 82.79% towards Staphylococcus aureus and Escherichia coli, respectively. This work provides a facile and efficient method for the synthesis of nanocellulose from coconut midrib and a useful approach to functionalize cellulose nanopaper. Cellulose nanopapers thus prepared were demonstrated to have applications in EMI shielding and antibacterial coating. 2025 The Royal Society of Chemistry.
New Journal of Chemistry;Volume;49;Issue;22;pp.9475-9483
All Open Access; Hybrid Gold Open Access
https://doi.org/10.1039/d5nj01022e https://www.scopus.com/pages/publications/105005742207?origin=resultslist
Jose J., Department of Chemistry, CHRIST University, Bengaluru, 560029, India; Vinod T.P., Department of Chemistry, CHRIST University, Bengaluru, 560029, India
Nanocomposites in Combating Antimicrobial Resistance
AMR; Antibacterial; Nanocomposite; Synergistic effect
Extensive and improper usage of antibiotics has resulted in the outbreak of multidrugresistant microorganisms and increasing antimicrobial resistance (AMR), which has become a significant threat to global health and health care. Resistant microorganisms adapt various resistance mechanisms like modifying the structure of antibiotics, altering the target, inhibiting the internalization of antibiotics, ejection of antibiotics from bacterial cells, etc. By lowering or completely disabling the efficacy of antibiotics, AMR may become a primary cause of mortality if left unattended. Developing effective antiresistance strategies to combat AMR is an urgent need of time. Nanomaterials have great potential to inactivate pathogens, and their mechanism of antimicrobial activity is different from antibiotics. With these unique mechanisms of antimicrobial action, nanomaterials are less prone to develop AMR. Developing nanocomposites can provide synergistic effects to improve the properties and strengthen the antimicrobial capability of individual nanomaterials. In this chapter, contemporary developments in the application of antimicrobial composites such as carbon nanocomposites, metallic nanocomposites, nonmetallic nanocomposites, metalloid nanocomposites, polymer nanocomposites, ceramic nanocomposites, and their hybrid forms to prevent the evolution of AMR will be discussed. The current research direction, prospects, and possible strategies to explore nanocomposites as potent antimicrobial agents to conquer AMR will be highlighted. The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024.
Varghese M.; Mathew A.A.; Balachandran M.
Nanotechnology Based Strategies for Combating Antimicrobial Resistance, pp. 203-230.
Varghese M., Department of Physics and Electronics, CHRIST (Deemed to be University), Karnataka, Bengaluru, India; Mathew A.A., Department of Physics and Electronics, CHRIST (Deemed to be University), Karnataka, Bengaluru, India; Balachandran M., Department of Physics and Electronics, CHRIST (Deemed to be University), Karnataka, Bengaluru, India
Nanoencapsulation of Ru(p-cymene) Complex Bearing Ginger-based Natural Product into Liposomal Nanoformulation to Improve Its Cellular Uptake and Antiproliferative Activity
6-gingerol; intracellular uptake; nanoencapsulation; polydiacetylene-phospholipid assembly; ROS-generation; Ru(p-cymene) complexes
The organometallic compounds are prospective candidates in the row of developing metallochemotherapeutics with the aim of overcoming the limitations of platinum drugs. In order to explore the anticancer properties of organometallic compounds with the natural medicines, two Ru(II)-p-cymene complexes containing the natural products, viz., 6-gingerol (6G) and benzylated-6-gingerdione (B-6GD) have been synthesized and characterized well. The phenolic group of the Ru(6G) complex facilitates its higher cell-free antioxidant activity than its analogue complex. Also, the same complex shows higher cytotoxicity toward A549 lung and HeLa-S3 cervical cancer cells than the Ru(B-6GD) complex but lower cytotoxicity toward A2058 metastatic melanoma cancer cells. Both complexes are shown to easily accumulate in melanoma cancer cells, and their degree of cytotoxicity in the same cells is found to be positively correlated with cell uptake. The cytotoxicity of complexes arises from their intracellular activity, mainly due to the induction of singlet oxygen production in cancer cells. The subcellular fractionation study shows that mitochondria and ER-Golgi membranes might be their predominant targets. Also, the mechanistic investigation revealed that Ru(B-6GD) induces caspase-dependent non-apoptotic cell death whereas Ru(6G) can induce caspase-independent non-apoptotic cell death. Furthermore, both complexes are found to moderately alter the adhesion properties of cancer cells, which is beneficial for antimetastatic treatment. Despite the potential pharmacological activity, Ru(6G) is encapsulated into polymer-supported liposomes to reduce its toxicity and further improve its anticancer potency. The ?-conjugated yne-ene chain of polydiacetylene aids in the development of a stable nanoformulation, which achieved a slow release of the complex. Most importantly, the cancer cell uptake of the liposome-encapsulated Ru(6G) complex is 20 times enhanced and the total ROS formation in cancer cells is significantly increased compared to the non-encapsulated complex. However, the nanoformulation does not alter the antimetastatic potency of the encapsulated complex. 2022 American Chemical Society. All rights reserved.
Sumithaa C.; Manjunathan T.; Mazuryk O.; Peters S.; Pillai R.S.; Brindell M.; Gopinath P.; Ganeshpandian M.
ACS Applied Bio Materials, Vol-5, No. 7, pp. 3241-3256.
https://doi.org/10.1021/acsabm.2c00231 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85134632163&doi=10.1021%2facsabm.2c00231&partnerID=40&md5=57eb42a7e36aedc684ceeb696340c885
Sumithaa C., Department of Chemistry, SRM Institute of Science and Technology, Tamil Nadu, Kattankulathur, 603 203, India; Manjunathan T., Department of Chemistry, SRM Institute of Science and Technology, Tamil Nadu, Kattankulathur, 603 203, India; Mazuryk O., Department of Inorganic Chemistry, Faculty of Chemistry, Jagiellonian University in Krak, Krakow, 30-387, Poland; Peters S., Department of Chemistry, SRM Institute of Science and Technology, Tamil Nadu, Kattankulathur, 603 203, India; Pillai R.S., Department of Chemistry, Christ University, Karnataka, Bangalore, 560029, India; Brindell M., Department of Inorganic Chemistry, Faculty of Chemistry, Jagiellonian University in Krak, Krakow, 30-387, Poland; Gopinath P., Department of Chemistry, SRM Institute of Science and Technology, Tamil Nadu, Kattankulathur, 603 203, India; Ganeshpandian M., Department of Chemistry, SRM Institute of Science and Technology, Tamil Nadu, Kattankulathur, 603 203, India
Nanofluid flow past a vertical plate with nanoparticle aggregation kinematics, thermal slip and significant buoyancy force effects using modified Buongiorno model
aggregation of nanoparticles; exponential space-based heat source; modified Buongiorno model; nanofluid; Nonlinear Boussinesq approximation; quadratic thermal radiation
The flow of ethylene glycol-based titania nanoliquid passing through a vertical plate induced by significant buoyancy forces (nonlinear convection) is analyzed with quadratic thermal radiation and considering the aggregation kinematics of the nanoparticles. The nanoliquid is modeled accounting for thermo-migration, Brownian motion, and the effectual thermophysical properties. The realistic zero mass flux and thermal slip conditions are considered on the surface of the plate. In addition, the mechanisms of exponential space-related heat source (ESHS) and thermal-based heat source (THS) are incorporated. The finite-difference technique-based bvp5c routine is used to obtain the numerical solution of thenonlinear system of equations. The effects of the parameters are examined on the dimensionless profiles of velocity, temperature, heat transport rate, the volume fraction of nanoparticles, and streamlines. It was found that the aggregation of nanoparticles significantly advances the temperature field while the velocity field is reduced. The ESHS and THS modulations improve the thickness of the thermal boundary layer. The quadratic thermal convection aspect improves the velocity of nanoliquid. Furthermore, the effects of quadratic thermal radiation assist the growth of the thermal boundary layer. The present results are relevant to various thermal systems including flat plate solar collectors, heat exchangers, and nuclear reactors. 2021 Informa UK Limited, trading as Taylor & Francis Group.
Rana P.; Mahanthesh B.; Mackolil J.; Al-Kouz W.
Waves in Random and Complex Media, Vol-34, No. 4, pp. 3425-3449.
Rana P., School of Mathematical Sciences, College of Science and Technology, Wenzhou-Kean University, Wenzhou, China; Mahanthesh B., Department of Mathematics, CHRIST (Deemed to be University), Bengaluru, India; Mackolil J., Department of Mathematics, CHRIST (Deemed to be University), Bengaluru, India; Al-Kouz W., Department of Mechanical and Maintenance Engineering, German Jordanian University, Amman, Jordan
Nanofluid flowing over a rotating disk that is stretching and permeable: An unsteady model
laminar flow; Nanofluid; rotating disk; suction; unsteady flow
The model presented in this paper deals with the investigation of the unsteady laminar flow past a stretchable disk. The nanofluids Al2O3/H2O and Cu/H2O are considered for the analysis where the thermal characteristics and flow behavior of these nanofluids are compared. In addition, the system is subjected to the suction force that has significant impacts on velocity of the nanofluid flow. Further, the nanoparticle solid volume fraction is another important parameter that is discussed which has a prominent role on both profiles of the nanofluid. Furthermore, the investigated mathematical model is framed using PDEs that are transformed to ODEs using suitable transformations. The system of equations obtained in this regard is solved by employing the RKF-45 numerical method where the results are obtained in the form of graphs. Various nanofluids flow parameters arise in the study and the impact of all these parameters has been analyzed and interpreted. Some of the major outcomes are that the higher values of nanoparticle solid volume fraction enhance the temperature while it decreases velocity of the flow. The comparison of flow of the two nanofluids concluded that aluminawater nanofluid has a better velocity while the copperwater nanofluid has a better thermal conductivity. World Scientific Publishing Company.
International Journal of Modern Physics B, Vol-37, No. 28
Puneeth V., Department of Computational Sciences, School of Sciences, CHRIST University, Bengaluru, 560029, India; Aly E.H., Department of Mathematics, Faculty of Education, Ain Shams University, Roxy, Cairo, Egypt; Pop I., Department of Mathematics, Babe?Bolyai University, Cluj Napoca, 400084, Romania
Nanomaterial - Based Electrochemical Sensor for Monitoring Potential Biomakers of Chronic Disorders
Detecting various biomarkers in the health industry and the biomedical sector has been newlinesignificant due to their crucial role in diagnosing, assessing, exposing, and treating disorders. This work reports electrochemical sensors for detecting biomarkers using different modifications (2D materials and nanomaterials) on carbon fiber paper electrode-based (CFPE) sensors. Adopting these modifications on the CFPE electrode greatly intensified the oxidation and reduction of peak current values. The physio-chemical characterizations of the designed electrodes were examined employing Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Electron Diffraction X-ray (EDX), X-Rayv Photoelectron spectroscopy (XPS), Fourier Transform Infrared Spectroscopy (FTIR), and Raman Spectroscopy. Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) newlineassisted in optimizing the electrochemical properties via Nyquist plots, sensing performance, scan rate effect, and pH effect. Both electro-activity studies and Nyquist plots confirmed the enhancement in the electroanalytical performance of the fabricated electrodes. Real sample newlinestudies were successfully analyzed using developed electrodes, producing good recovery newlinepercentages. Overall, all the works conducted have been established to be facile and selective, with novelty in the fabrication of ultrasensitive voltammetric-based sensors to quantify different biomarkers.
Nanomaterial- Based Electrochemical Sensors for Vitamins and Hormones
Women and adolescent girls around the globe have fallen prey to, or rather have become vulnerable to, infections and poor health conditions due to the deficiencies caused by their deprivation of vitamins and proteins along with hormonal imbalance resulting in a snowballing effect causing declining well-being among women. The methods currently available in assessing vital hormones and vitamins are time-consuming and expensive, thereby making them inaccessible to economically weaker sections of society. The work carried out so far in determining and quantifying these biomolecules has mostly employed immunosensing techniques on screen-printed electrodes. Glassy carbon electrodes or carbon paste electrodes modified with metal nanoparticles, graphene, and various polymerized films are also being used for the sensing of these biomolecules. In this chapter, the authors navigate a path through, and give a concise outlook on, various nanomaterial-based electrodes and their comparative efficiency for electrochemical sensing of vitamins and hormones. 2023 selection and editorial matter, Anitha Varghese and Gurumurthy Hegde; individual chapters, the contributors.
Cherian A.R.; Rajeev R.; Nidhin M.; Varghese A.; Hegde G.
Emerging Nanomaterials for Catalysis and Sensor Applications, pp. 249-270.
Cherian A.R., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Bengaluru, India; Rajeev R., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Bengaluru, India; Nidhin M., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Bengaluru, India; Varghese A., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Bengaluru, 560029, India; Hegde G., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Bengaluru, India
Nanomaterials as novel elicitors of pharmacologically active plant specialized metabolites in cell and organ cultures: current status and future outlooks
Cell cultures; Elicitor; Nanomaterials; Organ cultures
Specialized plant metabolites, such as phenolics, terpenes, terpenoids, nitrogen-containing compounds, and sulfur-containing compounds, are commercially valuable owing to their wide array of applications in the medical, pharmacological, cosmetic, agriculture, and food industries. Procuring valuable specialized metabolites from wild or cultivated plants is desirable; however, the concentrations and quality of secondary compounds vary between samples. Therefore, plant cells and organ cultures have been selected as viable alternatives for producing specialized metabolites. Elicitation is a strategy used to enhance the accumulation of specialized compounds in cell and organ cultures. Different biotic substances, including signaling chemicals such as salicylic acid and methyl jasmonate, elements of plant cell walls (cellulose and pectin), polysaccharides from microbes (chitin and glucan), and abiotic substances such as inorganic salts, heavy metals, UV radiation, and high salinity, have been successfully tested and used as elicitors for the hyperaccumulation of bioactive substances in cell and organ cultures. Recently, metals, metal oxide nanoparticles, and carbon-based nanomaterials have been used as unique elicitors to boost the synthesis of bioactive compounds in cell and organ cultures. The applications and usage of nanoparticles as elicitors in plant cell and organ cultures are summarized in this review. The mechanism of elicitation, toxicity, benefits, and drawbacks of using nanoparticles in plant cell and organ cultures are discussed. Graphical abstract: (Figure presented.) The Author(s), under exclusive licence to Springer Nature B.V. 2023.
Murthy H.N.; Joseph K.S.; Paek K.Y.; Park S.Y.
Plant Growth Regulation, Vol-104, No. 1, pp. 5-30.
Springer Science and Business Media B.V.
Murthy H.N., Department of Botany, Karnatak University, Dharwad, 580003, India, Department of Horticultural Science, Chungbuk National University, Cheongju, 28644, South Korea; Joseph K.S., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, 560029, India; Paek K.Y., Department of Horticultural Science, Chungbuk National University, Cheongju, 28644, South Korea; Park S.Y., Department of Horticultural Science, Chungbuk National University, Cheongju, 28644, South Korea
Nanomaterials for A431 Epidermoid Carcinoma Treatment
Drug delivery; Nanoparticles; Nanotherapeutics; Properties; Skin carcinoma
Malignancy is the ancient sickness that causes an increased rate of mortality worldwide. Traditional malignant growth treatments that are clinically utilized comprise chemotherapy, radiotherapy, and medical procedure. Despite the fact that there have been motivating enhancements in the nanotechnology and biomedical field, malignant growth remains the most urgent condition to treat, as the central reason for mortality. Nanotechnology has the possibility to improve medication transport and delivery by modifying pharmacokinetics and conveyance, resulting in reduced negative reactions and in this manner improving precision. Some issues exist regarding destinations and the difficulties that occur, and the potential for success becomes closer with every discovery. Nanomaterials are smaller in size than organic macromolecules. More correctly, they as a rule have a width of many nanometers (nm), which makes them from 100 up to multiple times smaller than even one malignancy cell. Nanoparticles can occur in sizes running from 10 up to 400nm, and can likewise be used with a simple set up or a blend of pharmacologically dynamic medications, depending on a superficial level of properties. The various aspect of nanotechnology for malignant growth treatment include exact targeting of the lively segments in cell/tissues, producing upgrades responsive medication discharge, defeating natural obstructions, interfacing against disease dynamic system with imaging atoms, improving disease examination, and imaging. For the most part, nanoparticles burdened with mending operators are conveyed experimentally for firm malignancy treatment. Todays nanotechnology is a magnificent platform for the treatment of differing malignant growths. 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.
Christobher S.; Kalitha Parveen P.; Easwaran M.; Bhotla H.K.; Kaliannan D.; Balasubramanian B.; Meyyazhagan A.
Nanotechnology in the Life Sciences, pp. 211-235.
Christobher S., Department of Zoology, Nallamuthu Gounder Mahalingam College, Tamil Nadu, Pollachi, India; Kalitha Parveen P., PG Department of Zoology, Hajee Karutha Rowther Howdia College of Arts and Science, Tamil Nadu, Uthamapalayam, India; Easwaran M., Bioknowl Insights Private Limited, Tamil Nadu, Coimbatore, India; Bhotla H.K., Bioknowl Insights Private Limited, Tamil Nadu, Coimbatore, India; Kaliannan D., Zoonosis Research Center, Department of Infection Biology, School of Medicine, Wonkwang University, Iksan, South Korea; Balasubramanian B., Department of Food Science and Biotechnology, College of Life Sciences, Sejong University, Seoul, South Korea; Meyyazhagan A., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, India
Nanomaterials Synthesized from Mangroves and Their Associates
Biomedical applications; Bionanomaterials; Green synthesis; Mangrove; Nanotechnology
Nanotechnology has great potential for developing nano-enabled equipment and products in a variety of industries, including personal care, medical, food, and agriculture. Despite the increasing use of metal nanoparticles in various domains, concerns concerning biological and environmental safety during manufacture remain. Traditional commercial methods for generating nanoparticles often entail chemical procedures and high-energy physical approaches that are both environmentally damaging and expensive. As an alternative, green synthesis employing plants has arisen, which reduces the requirement for toxic chemicals and severe reaction conditions in nanoparticle synthesis. The utilization of mangrove plants for nanoparticle synthesis has recently gained popularity due to their abundance of unique phytochemicals that aid in nanoparticle synthesis. Microorganisms in mangroves and enzymatic activities in plants can be utilized for a range of biotechnological and environmental uses. Bioactive compounds from mangrove resources show potential for creating bionanomaterials that can be utilized in environmental and biomedical fields. Bionanomaterials created from mangroves are incredibly effective in medical uses and cleaning up the environment. Bionanomaterials are produced by utilizing mangrove and various biomolecules obtained from mangrove plants as substances for the creation of nanoparticles. Bionanomaterials made from biomolecules offer benefits for the sustainable use of mangroves because of their large surface area, biocompatibility, and minimal toxicity. Here focuses on the potential of mangroves as a natural resource for producing bionanomaterials in various applications, promoting an eco-friendly approach. This chapter investigates various types of mangrove species and their elements utilized in creating nanoparticles, as well as the applications of the nanoparticles in therapy, agriculture, and industry. It also investigates the obstacles hindering the extensive utilization of plant-based nanoparticle synthesis. Springer Nature Switzerland AG 2025.
Gangwar, Jaya; Joseph, Kadanthottu Sebastian
Reference Series in Phytochemistry;Volume;Part F1;
Restricted Access; Hardcopy may be available in the library
https://doi.org/10.1007/978-3-031-63920-3_30-1 https://www.scopus.com/pages/publications/105015330394?origin=resultslist
Gangwar J., Department of Life Science, School of Sciences, Christ University, Bangalore, India; Joseph K.S., Department of Life Science, School of Sciences, Christ University, Bangalore, India
Nanotechnology has great potential for developing nano-enabled equipment and products in a variety of industries, including personal care, medical, food, and agriculture. Despite the increasing use of metal nanoparticles in various domains, concerns concerning biological and environmental safety during manufacture remain. Traditional commercial methods for generating nanoparticles often entail chemical procedures and high-energy physical approaches that are both environmentally damaging and expensive. As an alternative, green synthesis employing plants has arisen, which reduces the requirement for toxic chemicals and severe reaction conditions in nanoparticle synthesis. The utilization of mangrove plants for nanoparticle synthesis has recently gained popularity due to their abundance of unique phytochemicals that aid in nanoparticle synthesis. Microorganisms in mangroves and enzymatic activities in plants can be utilized for a range of biotechnological and environmental uses. Bioactive compounds from mangrove resources show potential for creating bionanomaterials that can be utilized in environmental and biomedical fields. Bionanomaterials created from mangroves are incredibly effective in medical uses and cleaning up the environment. Bionanomaterials are produced by utilizing mangrove and various biomolecules obtained from mangrove plants as substances for the creation of nanoparticles. Bionanomaterials made from biomolecules offer benefits for the sustainable use of mangroves because of their large surface area, biocompatibility, and minimal toxicity. Here focuses on the potential of mangroves as a natural resource for producing bionanomaterials in various applications, promoting an eco-friendly approach. This chapter investigates various types of mangrove species and their elements utilized in creating nanoparticles, as well as the applications of the nanoparticles in therapy, agriculture, and industry. It also investigates the obstacles hindering the extensive utilization of plant-based nanoparticle synthesis. Springer Nature Switzerland AG 2026.
Reference Series in Phytochemistry;Volume;Part F870;pp.643-661
https://doi.org/10.1007/978-3-031-91066-1_30 https://www.scopus.com/pages/publications/105015419332?origin=resultslist
Functionalization; Heavy metal ion; Nanocarbon; Nanocarbon-based materials; Nanotechnology; Sensing strategies; Water contamination
Nanotechnology is an achievement in the modern period because of its adaptable properties as per its size alterations. Nanomaterials with their size ranging from 1 to 100nm hold incredible novel properties and functionalities because of their molecular arrangements in nano-scale. Nanotechnologies add to pretty much every field of science, including material science, materials chemistry, physics, biology, software and computational engineering and so on. Lately, nanotechnology has been applied to different fields with promising outcomes, particularly in the field of detecting and remediation of toxicity levels, imperilling the ecological solidness just as it does to human wellbeing. One of the principal research interests using nanomaterials is detecting poisonous heavy metal ions. Carbon-based nanomaterials, which are remarkable in view of their toxic-free nature, high surface area and biocompatibility, are valuable for ecological treatments. Heavy metal pollution of water resources is a major issue that poses danger to health and wellbeing. Carbon-based nanomaterials have incredible potential for the detection as well as treatment of heavy metals from water sources in light of their large surface area, nano-scale and accessibility towards various functionalities as they are simpler to be chemically altered and hence reused. Apart from the conventional gas sensors based on SnO2, Fe2O3, In2O3 etc., gas sensors based on nanocarbons materials like carbon nanotubes (CNTs), nanosheets of graphene, carbon nano-fibres etc. exhibit high efficacy when it comes to gas-sensing strategy. Likewise, nanocarbon with hybrids of noble metals or semiconducting oxides can lead to a better performance considering gas-sensing applications. Here in this review, we describe the progress of carbon-based nanomaterials in toxicity detection and remediation. In addition to that, recent trends in nanomaterials-based sensing revealed the advancement of gas sensors based on nanocarbons. 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
Materials Horizons: From Nature to Nanomaterials, pp. 131-147.
Joseph N., Department of Physics & Electronics, CHRIST (Deemed to be University), Bangalore, India; Manoj B., Department of Physics & Electronics, CHRIST (Deemed to be University), Bangalore, India
Nanomedicine: Insight analysis of emerging biomedical research and developments
Cancer diagnostics; Drug delivery; Nanomedicine; Nanovaccine; Tumor imaging
The field of nanomedicine has undergone a revolution owing to the specific optical, electrical, and mechanical behaviors of nanomaterials that are extensively utilized for the detection of biomolecules, improved therapeutics, and imaging of diseased tissues. Different cells have their own unique markers which can be detected by specific nanomaterials which in turn can be used to target micro levels of medicine in precision medicine. Most of the advances in nanomedicine will have effects on the healthcare delivery systems. More works have focused on screening procedures that have better sensitivity and specificity for disease detection, which in turn will greatly improve diagnostic and prognostic domains, thereby reducing healthcare costs. Nanomedicine has the advantages of facilitating early disease detection, quantification of tumor cells and toxicmolecules, delivery of drugs to specific cells like the tumor cells etc. This chapter deals with research and development in nanomedicine which has been a top priority in most of the developed countries, with a view to optimize factors like dose response, efficacy, targeting ability, safety and bioavailability. The Author(s), under exclusive license to Springer Nature Switzerland AG 2023. All rights reserved.
Sarojini S.; Balakrishnan S.P.; Kootery K.P.; Biswas S.; Philip I.; Shitut A.; Baby A.; Jayaram S.
Nanovaccinology: Clinical Application of Nanostructured Materials Research to Translational Medicine, pp. 23-43.
Sarojini S., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, India; Balakrishnan S.P., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, India; Kootery K.P., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, India; Biswas S., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, India; Philip I., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, India; Shitut A., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, India; Baby A., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, India; Jayaram S., Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, India
Nanoparticle aggregation effects on radiative heat transport of nanoliquid over a vertical cylinder with sensitivity analysis
nanoliquid; nanoparticle (NP) aggregation; O302; response surface methodology (RSM); sensitivity analysis; surface heat flux
A sensitivity analysis is performed to analyze the effects of the nanoparticle (NP) aggregation and thermal radiation on heat transport of the nanoliquids (titania based on ethylene glycol) over a vertical cylinder. The optimization of heat transfer rate and friction factor is performed for NP volume fraction (1% ? ? ? 3%), radiation parameter (1 ? Rt ? 3), and mixed convection parameter (1.5 ? ? ? 2.5) via the face-centered central composite design (CCD) and the response surface methodology (RSM). The modified Krieger and Dougherty model (MKDM) for dynamic viscosity and the Bruggeman model (BM) for thermal conductivity are utilized to simulate nanoliquids with the NP aggregation aspect. The complicated nonlinear problem is treated numerically. It is found that the temperature of nanoliquid is enhanced due to the aggregation of NPs. The friction factor is more sensitive to the volume fraction of NPs than the thermal radiation and the mixed convection parameter. Furthermore, the heat transport rate is more sensitive to the effect of radiative heat compared with the NP volume fraction and mixed convection parameter. 2021, Shanghai University and Springer-Verlag GmbH Germany, part of Springer Nature.
Applied Mathematics and Mechanics (English Edition), Vol-42, No. 3, pp. 331-346.
Mahanthesh B., Department of Mathematics, CHRIST (Deemed to be University), Bangalore, 560029, Karnataka, India; Thriveni K., Department of Mathematics, CHRIST (Deemed to be University), Bangalore, 560029, Karnataka, India
Nanoparticle aggregation kinematics on the quadratic convective magnetohydrodynamic flow of nanomaterial past an inclined flat plate with sensitivity analysis
inclined plate; magnetohydrodynamic flow; nanofluid; Nanoparticle aggregation; quadratic convection; sensitivity analysis
The study focuses on the aggregation kinematics in the quadratic convective magneto-hydrodynamics of ethylene glycol-titania ((Formula presented.)) nanofluid flowing through an inclined flat plate. The modified Krieger-Dougherty and Maxwell-Bruggeman models are used for the effective viscosity and thermal conductivity to account for the aggregation aspect. The effects of an exponential space-dependent heat source and thermal radiation are incorporated. The impact of pertinent parameters on the heat transfer coefficient is explored by using the Response Surface Methodology and Sensitivity Analysis. The effects of several parameters on the skin friction and heat transfer coefficient at the plate are displayed via surface graphs. The velocity and thermal profiles are compared for two physical scenarios: flow over a vertical plate and flow over an inclined plate. The nonlinear problem is solved using the RungeKutta-based shooting technique. It was found that the velocity profile significantly decreased as the inclination of the plate increased on the other hand the temperature profile improved. The heat transfer coefficient decreased due to the increase in the Hartmann number. The exponential heat source has a decreasing effect on the heat flux and the angle of inclination is more sensitive to the heat transfer coefficient than other variables. Further, when radiation is incremented, the sensitivity of the heat flux toward the inclination angle augments at the rate 0.5094% and the sensitivity toward the exponential heat source augments at the rate 0.0925%. In addition, 41.1388% decrement in wall shear stress is observed when the plate inclination is incremented from (Formula presented.) to (Formula presented.). IMechE 2021.
Sabu A.S.; Mackolil J.; Mahanthesh B.; Mathew A.
Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering, Vol-236, No. 3, pp. 1056-1066.
Sabu A.S., Department of Mathematics, St. Thomas College (Autonomous), Thrissur, India; Mackolil J., Centre for Mathematical Needs, Department of Mathematics, CHRIST (Deemed to be University), Bengaluru, India; Mahanthesh B., Centre for Mathematical Needs, Department of Mathematics, CHRIST (Deemed to be University), Bengaluru, India; Mathew A., Department of Mathematics, St. Thomas College (Autonomous), Thrissur, India
Nanoparticles and convergence of artificial intelligence for targeted drug delivery for cancer therapy: Current progress and challenges
artificial intelligence; biomarker; cancer; cancer therapy; drug delivery; nanoparticles
Cancer is a life-threatening disease, resulting in nearly 10 million deaths worldwide. There are various causes of cancer, and the prognostic information varies in each patient because of unique molecular signatures in the human body. However, genetic heterogeneity occurs due to different cancer types and changes in the neoplasms, which complicates the diagnosis and treatment. Targeted drug delivery is considered a pivotal contributor to precision medicine for cancer treatments as this method helps deliver medication to patients by systematically increasing the drug concentration on the targeted body parts. In such cases, nanoparticle-mediated drug delivery and the integration of artificial intelligence (AI) can help bridge the gap and enhance localized drug delivery systems capable of biomarker sensing. Diagnostic assays using nanoparticles (NPs) enable biomarker identification by accumulating in the specific cancer sites and ensuring accurate drug delivery planning. Integrating NPs for cancer targeting and AI can help devise sophisticated systems that further classify cancer types and understand complex disease patterns. Advanced AI algorithms can also help in biomarker detection, predicting different NP interactions of the targeted drug, and evaluating drug efficacy. Considering the advantages of the convergence of NPs and AI for targeted drug delivery, there has been significantly limited research focusing on the specific research theme, with most of the research being proposed on AI and drug discovery. Thus, the study's primary objective is to highlight the recent advances in drug delivery using NPs, and their impact on personalized treatment plans for cancer patients. In addition, a focal point of the study is also to highlight how integrating AI, and NPs can help address some of the existing challenges in drug delivery by conducting a collective survey. 2023 Das and J.
All Open Access; Gold Open Access; Green Open Access
https://doi.org/10.3389/fmedt.2022.1067144 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85149135206&doi=10.3389%2ffmedt.2022.1067144&partnerID=40&md5=abbb2f6d774b0d23e407f0215b0b04f3
Das K.P., Department of Computer Science, Christ University, Bangalore, India; Chandra J., Department of Computer Science, Christ University, Bangalore, India
Nanoparticles as fillers in composites for x-ray and gamma-ray shielding: A review
In last few decades, nanomaterials have gained enormous attention in the scientific industry due to their tunable physico-chemical and biological properties with enhanced performance over their bulk counterparts. In particular, nanoparticles have been extensively investigated for their usefulness in X-ray and gamma-ray shielding applications. Various elements and compounds, with high atomic numbers and effective atomic numbers respectively, have the potential to form nanoparticles that offer remarkable enhancement in the shielding performance. Composites, obtained by doping different nanoparticles into structural matrices (concrete, glass, or polymers), not only possess striking thermo-mechanical properties but also are effective shielding materials to replace conventional lead shields. This review is an attempt to throw light on various aspects of nanoparticles and their influence on shielding effectiveness. The authors also summarize the experimental findings so as to highlight the potential underlying the radiation-matter interaction mechanism in nanostructured systems. Copyright 2023, IGI Global.
Diversity and Applications of New Age Nanoparticles, pp. 246-266.
Prabhu S., CHRIST University (Deemed), India; Bubbly S.G., CHRIST University (Deemed), India; Gudennavar S.B., CHRIST University (Deemed), India
Nanoremediation of Groundwater Contaminants Through Mycosynthesized CuONPs and ZnONPs
Copper oxide nanoparticles; Endophytic fungi; Nanoremediation; Phytochemicals; Zinc oxide nanoparticles
The global wide threatening problem is the pollution, especially water and soil pollution are biggest threats to our people. The pollution not only damages the resources but also enters the ecosystem and impairs our health. The pollution disfigures the fertility of the soil and contaminates the groundwater table which is the most reliable source of all living organisms. Due to urbanization of people and scarcity of the water resources, the people rely on the groundwater for the domestic and drinking needs. Earlier researches include the bioremediation and physico-chemical mechanisms in removal of toxic/heavy metals from water but still faced several post-treatment issues. The advancement in science and technology paved a path as nanotechnology to overcome these problems. In this current investigation, the CuO nanoparticles (CuONPs) and ZnO nanoparticles (ZnONPs) were synthesized from endophytic fungal strain and characterized which were previously reported. The groundwater samples were collected near, in, and around of the garbage-dump site of Vellalore-Kurichi village, Coimbatore, Tamil Nadu, India; three areas were selected, and water samples were collected. The basic physico-chemical parameters such as BOD, COD, TDS, hardness, pH, chlorides, sulfates, nitrates, and heavy metal(s) of the collected samples were analyzed. The adsorption studies were initiated with three different concentrations of CuONPs and ZnONPs in 100mL of polluted groundwater samples, and the kinetics was started with 0th min and extended till 180min. The adsorption rate increased with the increase in time; the CuONPs and ZnONPs adsorbed the few pollutants that also included arsenic (V) effectively. The nanoremediated samples were further taken to determine the effectiveness in aiding the plant growth promotion, and this was executed in Trigonella sp. plants. The plants were grown well which was compared to the control plants, and the phytochemical assessment was carried out. The presence of phytochemicals of the plants grown in nanoremediated samples was similar to that of control plants. Further, the CuONPs and ZnONPs have the ability in remediating the pollutants/contaminants in the groundwater. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
Mani, Vellingiri Manon; Mohammedbasha, Munaf; Sabarathinam, Shanmugam; Umesh, Mridul; Paramasivam, Deepak
BioNanoScience;Volume;15;Issue;1;Article No.;175;
https://doi.org/10.1007/s12668-024-01776-4 https://www.scopus.com/pages/publications/85217632962?origin=resultslist
Mani V.M., Department of Life Sciences, Kristu Jayanti College, Karnataka, Bengaluru, 560077, India, Department of Biotechnology, RVS College of Arts and Science, Tamil Nadu, Coimbatore, 641402, India; Mohammedbasha M., Department of Biotechnology, RVS College of Arts and Science, Tamil Nadu, Coimbatore, 641402, India, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei City, 10608, Taiwan; Sabarathinam S., Department of Microbial Biotechnology, Bharathiar University, Coimbatore, 641046, India; Umesh M., Department of Life Sciences, Christ University, Karnataka, Bengaluru, India; Paramasivam D., Department of Life Sciences, Kristu Jayanti College, Karnataka, Bengaluru, 560077, India
Nanoscale synthesis of nickel oxide@carboxy methyl cellulose@nitrogen doped carbon nanotubes supported metal organic frameworks ternary composite for use symmetric supercapacitor
Carboxymethyl cellulose (CMC); Electrochemical supercapacitor; MOF-67; N-MWCNT; Nickel oxide (NiO); Ternary composite
Metal-organic frameworks (MOFs) are a novel class of porous materials that combine organic linkers and inorganic metal ions. Supercapacitors use a large specific surface area, adjustable architecture, and tunable porosity and pore diameters to improve the electrochemical performances with metal sulfides. The main goal of this study was to make a nickel oxide ternary composite using a hydrothermal method with urea as a catalyst for electrochemical uses. We characterized these fabricated composite materials using analytical and morphological characterization for their confirmation. These results show that the composite electrode had a great specific capacitance of 464 F/g at 0.5 A/g in a 1 M KOH electrolyte when set up with three electrodes. The symmetric two-electrode system showed 52.83 F/g at 0.5 A/g with an excellent energy density of 13.14 Whkg?1 and a power density of 616 Wkg?1 via 1 M KOH electrolyte. The fabricated ternary composite electrode demonstrated cyclic stability, with an excellent retention rate of 89 % after 7000 cycles. Therefore, the fabricated ternary composite electrode materials have enormous potential for electrochemical storage properties. 2025 Elsevier B.V.
Ramesh, Sivalingam; Rabani, Iqra; Thangavelu, Indumathi; Yadav, H.M.; Selvaraj, Manickam; Saritha, Appukuttan; Seo, Young-Soo; Kim, Joo-Hyung; Kim, Heung Soo
International Journal of Biological Macromolecules;Volume;318;Issue;;Article No.;144901;
https://doi.org/10.1016/j.ijbiomac.2025.144901 https://www.scopus.com/pages/publications/105007453772?origin=resultslist
Ramesh S., Department of Mechanical, Robotics and Energy Engineering, Dongguk University, 30, Pil-dong, Jung-gu, Seoul, 04620, South Korea; Rabani I., Antwerp engineering, Photo electrochemistry and Sensing (APECS), University of Antwerp, Groenenborgeriaan,171, Antwerp, 2020, Belgium; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bangalore, 560029, India; Yadav H.M., School of Nanoscience and Bio-Technology, Shivaji University, Kolhapur, 416004, India; Selvaraj M., Department of Chemistry, Faculty of Science, King Khalid University, Abha, 61413, Saudi Arabia, Research Center for Advanced Materials Science (RCAMS), King Khalid University, AlQura'a, P.O. Box 960, Abha, Saudi Arabia; Saritha A., Department of Chemistry, Amrita Vishwa Vidyapeetham, Amritapuri, Kerala, Kollam, India; Seo Y.-S., Interface Lab, Department of Nanotechnology and Advanced Materials Engineering, Sejong University, Seoul, 05006, South Korea; Kim J.-H., Department of Mechanical Engineering, Inha University, Inha-ro,100, Namgu, Incheon, 22212, South Korea; Kim H.S., Department of Mechanical, Robotics and Energy Engineering, Dongguk University, 30, Pil-dong, Jung-gu, Seoul, 04620, South Korea
Nanosheets of nickel, cobalt and manganese triple hydroxides/oxyhydroxides as efficient electrode materials for asymmetrical supercapacitors
Transition metals play a significant role in energy storage applications mainly as electrode materials in supercapacitors. In this work, triple hydroxide/oxyhydroxide nanosheets of a nickel, cobalt and manganese (NCM) composite were electrochemically deposited on carbon cloth (CC) and used as electrode materials in supercapacitors. In a three electrode system the composite delivered a specific capacitance of 707 F g -1 at a current density of 3 A g -1 which retained its stability even at a higher current density of 50 A g -1 . An asymmetric supercapacitor (ASC) was assembled and characterized using NCM as the positive electrode, activated carbon as the negative electrode and Whatman filter paper soaked in KOH as the separator. The device operated in a working potential window of 1.75 V and it delivered a power density of 13.12 kW kg -1 and an energy density of 23.7 W h kg -1 . 2019 The Royal Society of Chemistry.
Reghu Nath A.; Jayachandran A.; Sandhyarani N.
Dalton Transactions, Vol-48, No. 13, pp. 4211-4217.
ISSN: 14779226; PubMed ID: 30843558; CODEN: DTARA
https://doi.org/10.1039/c9dt00302a https://www.scopus.com/inward/record.uri?eid=2-s2.0-85063488088&doi=10.1039%2fc9dt00302a&partnerID=40&md5=e900923449377f33614d3b51e5eada18
Reghu Nath A., Nanoscience Research Laboratory, School of Nano Science and Technology, National Institute of Technology Calicut, Calicut, Kerala, India; Jayachandran A., CHRIST (Deemed to Be University), Hosur Road, Bengaluru, Karnataka, India; Sandhyarani N., Nanoscience Research Laboratory, School of Nano Science and Technology, National Institute of Technology Calicut, Calicut, Kerala, India