Environmental Pollutants as Emerging Concerns for Cardiac Diseases: A Review on Their Impacts on Cardiac Health
subject: cardiac health; cardiovascular diseases (CVDs); environmental pollutants; health risk factors; particulate matter
description: Comorbidities related to cardiovascular disease (CVD) and environmental pollution have emerged as serious concerns. The exposome concept underscores the cumulative impact of environmental factors, including climate change, air pollution, chemicals like PFAS, and heavy metals, on cardiovascular health. Chronic exposure to these pollutants contributes to inflammation, oxidative stress, and endothelial dysfunction, further exacerbating the global burden of CVDs. Specifically, carbon monoxide (CO), ozone, particulate matter (PM2.5), nitrogen dioxide (NO2), sulfur dioxide (SO2), heavy metals, pesticides, and micro- and nanoplastics have been implicated in cardiovascular morbidity and mortality through various mechanisms. PM2.5 exposure leads to inflammation and metabolic disruptions. Ozone and CO exposure induce oxidative stress and vascular dysfunction. NO2 exposure contributes to cardiac remodeling and acute cardiovascular events, and sulfur dioxide and heavy metals exacerbate oxidative stress and cellular damage. Pesticides and microplastics pose emerging risks linked to inflammation and cardiovascular tissue damage. Monitoring and risk assessment play a crucial role in identifying vulnerable populations and assessing pollutant impacts, considering factors like age, gender, socioeconomic status, and lifestyle disorders. This review explores the impact of cardiovascular disease, discussing risk-assessment methods, intervention strategies, and the challenges clinicians face in addressing pollutant-induced cardiovascular diseases. It calls for stronger regulatory policies, public health interventions, and green urban planning. 2025 by the authors.
creator: Kumar V.; S H.; Huligowda L.K.D.; Umesh M.; Chakraborty P.; Thazeem B.; Singh A.P.
source: Biomedicines, Vol-13, No. 1
publisher: Multidisciplinary Digital Publishing Institute (MDPI)
date: 2025-01-01
rights: Restricted Access
relation: ISSN: 22279059
format: Online
language: English
type: Review
coverage: Kumar V., Biomaterials & Tissue Engineering (BITE) Laboratory, Department of Community Medicine, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, SIMATS, Chennai, Tamil Nadu, Thandalam, 602105, India; S H., Biomaterials & Tissue Engineering (BITE) Laboratory, Department of Community Medicine, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, SIMATS, Chennai, Tamil Nadu, Thandalam, 602105, India; Huligowda L.K.D., Institute for Water and Wastewater Technology, Durban University of Technology, Durban, 4001, South Africa; Umesh M., Department of Life Sciences, Christ University, Hosur Road, Karnataka, Bengaluru, 560029, India; Chakraborty P., Area of Molecular Medicine, Department of Allied Healthcare and Sciences, JAIN (Deemed to be University), Karnataka, Bangalore, 560066, India; Thazeem B., Waste Management Division, Integrated Rural Technology Centre (IRTC), Kerala, Palakkad, 678592, India; Singh A.P., Frankel Cardiovascular Center, Department of Medicine, University of Michigan, Ann Arbor, 48109, MI, United States

The puzzle of pheromones in nature and their mysterious influence: a comprehensive review
subject: Chemical synthesis; Molecular pathway; Pheromones; Synthetic pheromone
description: Pheromones are chemical signals that are given off by creatures to communicate with other conspecifics. Because of their influence on animal behavior and relationships throughout the animal world, pheromones have fascinated scientists for decades. The newest findings and new perspectives on the intriguing field of pheromones are synthesized in this thorough review article. We investigate the many roles played by pheromones, from mating attraction and territorial marking to alarm signaling and social organization. The chemical diversity of pheromones is explored in depth in this paper, highlighting the variety of substances used by different animals as messengers. We go over the processes involved in pheromone detection and processing to help understand how chemosensory receptors and brain circuits interact in complex ways. Additionally, we discuss the role that pheromones play in ecology and evolution by promoting speciation and adaptation. This review emphasizes both the new research on pheromones in humans as well as their function in the animal world. We investigate the data supporting human pheromones and their possible impact on social and reproductive behaviors. The review aims to offer a detailed exploration and insight into the role and effects of pheromones in the natural world. This includes examining the chemical essence of pheromones and their functionality as communication signals across different species, investigating the specificity of these chemicals to certain species and how non-specific pheromones come about, and delving into the evolution of pheromones with a focus on the physiological and evolutionary mechanisms that drive communication. Additionally, the review seeks to understand the role pheromones play in pest management, specifically how species-specific pheromones can be utilized in eco-friendly pest control strategies. It will also explore the enigmatic impact pheromones have on the behavior and interactions within and among species. Dra…
creator: Rixon M.; Pappuswamy M.; Chaudhary A.; Ansar S.S.
source: Journal of Applied Biology and Biotechnology, Vol-13, No. 1, pp. 24-36.
publisher: Open Science Publishers LLP Inc.
date: 2025-01-01
rights: All Open Access; Gold Open Access
relation: ISSN: 2347212X
format: Online
language: English
type: Review
coverage: Rixon M., Department of Life Sciences, School of Sciences, Christ University, Karnataka, Bengaluru, India; Pappuswamy M., Department of Life Sciences, School of Sciences, Christ University, Karnataka, Bengaluru, India; Chaudhary A., Department of Life Sciences, School of Sciences, Christ University, Karnataka, Bengaluru, India; Ansar S.S., Department of Life Sciences, School of Sciences, Christ University, Karnataka, Bengaluru, India

Integration of Hyperspectral Imaging and Deep Learning for Sustainable Mangrove Management and Sustainable Development Goals Assessment
subject: Convolutional Neural Network (CNN); Deep Learning (DL); Hyperspectral Image (HSI); Mangrove ecosystems; Sustainable Development Goals (SDGs)
description: Mangrove forests support biodiversity and provide valuable ecosystem services. Their conservation is important for maintaining these benefits. In addition to this, understanding and preserving these forests is important for the assessment of Sustainable Development Goals (SDGs) such as SDG 1,2,3,6,8,11,12,13,14 and15. This review paper explores how the integration of Hyperspectral Image (HSI) technology and Deep Learning (DL) algorithms is helpful in mangrove conservation and SDGs assessment. HSI in mangrove research allows detailed analysis of tree health, species types and environmental stress factors (includes salinity levels, waterlogging, soil erosion, pollution, habitat fragmentation, disturbances from human activities etc.) with enhanced spectral and spatial resolution. Combining DL algorithms like Convolutional Neural Network (CNN) with HSI data automates mangrove mapping, detects change in mangrove health, estimates carbon sequestration and manages ecological zone. Rich spectral information from HSI empowers DL algorithms to identify patterns and features for accurate and efficient classification tasks in both supervised and unsupervised methods. This review aims to comprehensively summarize the research efforts reported in monitoring mangrove ecosystems through varied remote sensing approaches, algorithms and their support towards SDGs assessment. HSI and DL together offer a powerful approach for researchers, environmentalists and climate activists working towards sustainable development objectives. This paper not only focuses on mangrove conservation but also addresses challenges associated with integrating technologies such as data processing complexities and the need for specialized expertise. This study outlines advancements in HSI technology, DL applications and future directions to drive sustainable management strategies for mangrove ecosystems. The Author(s), under exclusive licence to Society of Wetland Scientists 2025.
creator: Ilamathi P.; Chidambaram S.
source: Wetlands, Vol-45, No. 1
publisher: Springer Science and Business Media B.V.
date: 2025-01-01
rights: Restricted Access
relation: ISSN: 2775212
format: Online
language: English
type: Review
coverage: Ilamathi P., Department of Electronics and Communication Engineering, CHRIST University, Bengaluru, India; Chidambaram S., Department of Electronics and Communication Engineering, CHRIST University, Bengaluru, India

Metaverse marketing: a review and future research agenda
subject: Marketing strategies; Metaverse; Privacy and ethics; Research agenda
description: Purpose: The metaverse represents a rapidly evolving digital environment that blurs the lines between physical and virtual reality, and it offers unique opportunities and challenges for businesses and marketers. The purpose of this study is to provide a comprehensive review of metaverse marketing research. The present study reviews the literature on metaverse to identify theories, contexts, gaps and methodologies using TCCM framework (Theories, Contexts, Characteristics and Methodology) to set a future research agenda. Design/methodology/approach: A review was conducted of 179 English papers related to metaverse marketing from 2010 to 2023 from the Scopus and Web of Science core collection after applying relevant filters using the TCCM framework. Findings: The findings suggest that the studies have inadequately distinguished metaverse as something that only builds interactive experiences that combine the virtual environment and the real world, whereas the theoretical domain of metaverse is dominated by studies in various domains. The applicability of metaverse marketing research is pertinent in various domains of the management field. The study explores various facets of metaverse marketing to capture its dynamic nature. Research limitations/implications: By presenting a comprehensive review, themes and knowledge gaps of the research on metaverse marketing, this study will enhance research output and provide valuable tools for future research on metaverse. Practical implications: By analyzing metaverse in marketing, the companies will be able to use this concept effectively to formulate innovative marketing strategies and personalized consumer experiences and understand consumer behavior. Furthermore, research into metaverse marketing will be helpful in offering predictions about future trends in consumer behavior, technology adoption and virtual world development. Originality/value: This study provides a thorough analysis of the current state of research on metaver…
creator: Kumar R.; Aneja P.; Jadaun R.; Kiran P.B.N.; Saxena N.; Saxena S.; Singh P.K.; Painoli A.K.
source: Information Discovery and Delivery
publisher: Emerald Publishing
date: 2025-01-01
rights: Restricted Access
relation: ISSN: 23986247
format: Online
language: English
type: Review
coverage: Kumar R., School of Management, Doon University, Dehradun, India; Aneja P., School of Business, UPES, Dehradun, India; Jadaun R., Department of Management, Graphic Era Hill University, Dehradun, India; Kiran P.B.N., School of Business and Management, Christ University, Bengaluru, India; Saxena N., Department of Management, Neville Wadia Institute of Management Studies and Research, Pune, India; Saxena S., Department of Management, International School of Business and Media, Pune, India; Singh P.K., School of management, Doon University, Dehradun, India; Painoli A.K., Department of Management, Baddi University of Emerging Sciences and Technology, Baddi, India

Effectiveness of Couple Interventions in Marital Distress: A Systematic Review and Meta-Analysis
subject: Conflict intervention effect; Couple therapy; Hope therapy; Marital conflict resolution; Marital therapy
description: Background: Couple interventions focus on resolving relationship issues and improving partners' intimacy. Several intervention models are used on different occasions to deal with the issues. The present systematic review and meta-analysis investigated the effectiveness of such couple interventions dealing with marital distress. Methods: Using the PRISMA guidelines for reporting systematic reviews and meta-analyses, a search was carried out to identify published articles in the areas of study. The meta-analysis investigated the effectiveness of couple interventions by comparing the post-intervention assessments of the experimental and control groups. Results: The systematic review helped to identify twelve empirical studies published within the last ten years in the following databases: ScienceDirect, EBSCO, APA PsycINFO, NCBI, ProQuest, and Google Scholar. Meta-analysis showed a statistically significant overall effect size (Cohen's d = 0.85, 95% CI: 0.56-1.14). Cochran's Q showed that there was a substantial difference between the studies. There were signs of publication bias. Conclusion: The current study revealed an overall large effect size, indicating that different couple interventions had a noticeable impact on distressed couples who received interventions as opposed to couples who did not receive any interventions. 2025 Joesph et al.
creator: Joseph B.; Joseph V.K.; Rajan S.K.
source: Iranian Journal of Public Health, Vol-54, No. 1, pp. 112-123.
publisher: Tehran University of Medical Sciences
date: 2025-01-01
rights: All Open Access; Gold Open Access
relation: ISSN: 22516085
format: Online
language: English
type: Review
coverage: Joseph B., School of Psychological Sciences, CHRIST University, Bangalore, India; Joseph V.K., School of Psychological Sciences, CHRIST University, Bangalore, India; Rajan S.K., School of Psychological Sciences, CHRIST University, Bangalore, India

Production, Delivery, and Regulatory Aspects for Application of Plant-Based Anti-microbial Peptides: a Comprehensive Review
subject: Bioinformatics; Food spoilage; Nano delivery; Plant antimicrobial peptides; Synthetic peptides
description: Antimicrobial peptides (AMPs) are small, positively charged biomolecules produced by various organisms such as animals, microbes, and plants. These AMPs play a significant role in defense mechanisms and protect from adverse conditions. The emerging problem of drug resistance in microbes poses a global health challenge in treating diseases. This plant-based antimicrobial peptide is a promising candidate for fighting against drug-resistant microbes. The PAMPs process specific key properties, proving their efficacy as antimicrobial agents against a broad spectrum of microbes such as Gram-positive, Gram-negative, and fungi. Extensive research on PAMPs has explored their potential as plant growth regulators and therapeutic agents. Their diverse mode of action on microbes encouraged their application in food industries. ThePAMPs are isolated and purified from various plant species organs such as roots, shoots, leaves, flowers, and seeds. These are bioactive molecules with significant stability, and low toxicity has encouraged their application as food additives. Furthermore, to meet the consumer demand, mass production of AMPs was possible with recombinant DNA technology. The advanced and nanotechnology-based delivery system has significantly improved the efficacy and bioavailability of PAMPs as food preservatives for improved shelf-life and prevent spoilage of food products. ThePAMPs are of green origin and can be used as natural bio preservatives that do not alter the sensory properties of food and are harmless to consumers. Plants being the rich resource of AMPs to support their quick identification, and retrieval for commercial applications there is a need to integrate the omics approach with databases. TheAMPs are small, positively charged biomolecules produced by various organisms such as animals, microbes, and plants. These AMPs play a significant role in defense mechanisms and protect from adverse conditions. The emerging problem of drug resistance in microbes pos…
creator: Nagella P.; Balasubramanian B.; Park S.; Singh U.; Jayan A.; Mukherjee S.; Nizam A.; Meyyazhagan A.; Pappuswamy M.; Sebastian J.K.; Lakshmaiah V.V.; Mousavi Khaneghah A.
source: Probiotics and Antimicrobial Proteins
publisher: Springer
date: 2025-01-01
rights: Restricted Access
relation: ISSN: 18671306
format: Online
language: English
type: Review
coverage: Nagella P., Department of Life Sciences, Christ University, Karnataka, Bangalore, 560 029, India; Balasubramanian B., Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, 05006, South Korea; Park S., Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, 05006, South Korea; Singh U., Department of Life Sciences, Christ University, Karnataka, Bangalore, 560 029, India; Jayan A., Department of Life Sciences, Christ University, Karnataka, Bangalore, 560 029, India; Mukherjee S., Department of Life Sciences, Christ University, Karnataka, Bangalore, 560 029, India; Nizam A., Department of Chemistry, Christ University, Karnataka, Bangalore, 560 029, India; Meyyazhagan A., Department of Life Sciences, Christ University, Karnataka, Bangalore, 560 029, India; Pappuswamy M., Department of Life Sciences, Christ University, Karnataka, Bangalore, 560 029, India; Sebastian J.K., Department of Life Sciences, Christ University, Karnataka, Bangalore, 560 029, India; Lakshmaiah V.V., Department of Life Sciences, Christ University, Karnataka, Bangalore, 560 029, India; Mousavi Khaneghah A., Faculty of Biotechnologies (BioTech), ITMO University, 9 Lomonosova Street, Saint Petersburg, 191002, Russian Federation

Food additives and contaminants in infant foods: a critical review of their health risk, trends and recent developments
subject: Child health; Food additives; Health risk; Immunological responses; Infant formula food
description: The infant food market has expanded rapidly over the past two decades. However, the industry faces significant challenges, including concerns over the health effects of infant food additives and issues with food safety. However, new evidences suggest that certain food additives, such as those used to preserve and transport infant formula to keep it fresh for longer, should be avoided. Science into the effects of additives on human behavior makes up a sizable sector of the additives market. Problems such as hypernatremic dehydration, malnutrition, and obesity in infants are directly linked to faulty formula production. The Food and Drug Administration (FDA) has established the toxicity types and chemical tests necessary for evaluating the safety of food additives and GRAS (Generally Recognized as Safe) compounds. These tests are crucial in understanding the food safety aspects of food additives. The health effects of different types of food additives on infants are discussed in this context. The article gives an outline of various national and global agencies that provides recommendations and standards to gauge the quality of baby food. The immunological responses, allergic reaction pathways and other related health hazards among the infants and young children caused by the food additive are discussed in this article. Graphical Abstract: (Figure presented.) The Author(s) 2024.
creator: Soni S.; W A.J.; Kurian C.; Chakraborty P.; Paari K.A.
source: Food Production, Processing and Nutrition, Vol-6, No. 1
publisher: BioMed Central Ltd
date: 2024-01-01
rights: All Open Access; Gold Open Access
relation: ISSN: 26618974
format: Online
language: English
type: Review
coverage: Soni S., Department of Life Sciences, CHRIST (Deemed to be) University, Central Campus, Hosur Road, Karnataka, Bangalore, 560029, India; W A.J., Department of Life Sciences, CHRIST (Deemed to be) University, Central Campus, Hosur Road, Karnataka, Bangalore, 560029, India; Kurian C., Department of Life Sciences, CHRIST (Deemed to be) University, Central Campus, Hosur Road, Karnataka, Bangalore, 560029, India; Chakraborty P., Netaji Subhas Open University, Regional Centre, Durgapur, Paschim Bardhaman, India; Paari K.A., Department of Life Sciences, CHRIST (Deemed to be) University, Central Campus, Hosur Road, Karnataka, Bangalore, 560029, India

Polymer photosupercapacitors: combined nanoarchitectonics with polymer solar cell and supercapacitor for emerging powerpacks in next-generation energy applications
description: Efficient energy harvesting and storage are inevitable for the sustenance and growth of mankind, wherein the utilization of advanced technologies in this field has brought a significant impact on the energy sector. Integration of energy harvesting and storage devices is a need for powering next-generation energy needs like the Internet of Things (IoT), opening a wide range of application areas like wearable devices or integration with fabrics. Among third-generation solar cells, organic or polymer solar cells are extremely environment-friendly, lightweight, and flexible, making themselves potential candidates for integrated powerpacks along with supercapacitors. This article is a comprehensive review of polymer solar cell-based photosupercapacitors and their developments over the recent years. Through this review, we intend to give a valid account of polymer photosupercapacitors, to the scientific community regarding recent updates, which would help develop future approaches and strategies. As these integrated devices are considered to have a profound impact on energy industries and related applications, we believe that a detailed review of the present status and future prospects would aid further developments in the research field. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
creator: Jacob S.; George J.; Balachandran M.
source: Journal of Materials Science, Vol-59, No. 47, pp. 21649-21683.
publisher: Springer
date: 2024-01-01
rights: Restricted Access
relation: ISSN: 222461; CODEN: JMTSA
format: Online
language: English
type: Review
coverage: Jacob S., Department of Physics and Electronics, Christ University, Karnataka, Bengaluru, India; George J., Department of Physics and Electronics, Christ University, Karnataka, Bengaluru, India; Balachandran M., Department of Physics and Electronics, Christ University, Karnataka, Bengaluru, India

Potential of insect-based milk moiety from Pacific beetle cockroach, Diploptera punctata (Blattodea): Insights as superfood
subject: Cockroach milk; D. punctata; Lili-Mip; Milk crystal and protein; Superfood; Viviparity
description: Diploptera punctata is a viviparous cockroach and secretes a concoction of glycosylated proteins as a basis of nutrition for developing embryos termed as cockroach milk. The milk proteins were identified as the lipocalin-like milk proteins (Lili-Mip) which are present in the brood sac of the gestated female D. punctata. Blotting techniques and RNA transcriptome assays have reported analogous Lili-Mip in the midgut of D. puncta embryos, which proved the ingestion during development inside brood sac. Thermodynamics and kinetic studies augmented the stability of the milk crystals and their controlled release mechanism of sustenance. Gene ontogeny reported the evolution of the ovoviviparous to viviparous due to selective pressures posed during the development stages of the embryos. Molecular simulation modelling studied unveiled the binding efficacies of the milk protein to build strong affiliates to the ligands to form a stable milk protein complex. Ahead of its nutritional benefits, cockroach milk also offers environmental advantages compared to traditional dairy and plant-based milk production. Nevertheless, there are still important hurdles to overcome to include this unconventional superfood as staple in human diets which are also discussed in the review. This review explored the existing molecular, evolutionary and biochemical insights for understanding the phenomena of the production of milk crystals and addressed the research gaps for developing a novel nutrient prospective from insect source. 2024 Korean Society of Applied Entomology
creator: Pushparaj K.; Pechimuthu C.; Pappuswamy M.; Balasubramanian B.
source: Journal of Asia-Pacific Entomology, Vol-27, No. 4
publisher: Elsevier B.V.
date: 2024-01-01
rights: Restricted Access
relation: ISSN: 12268615
format: Online
language: English
type: Review
coverage: Pushparaj K., Department of Zoology, School of Biosciences, Avinashilingam Institute for Home Science and Higher Education for Women, Tamil Nadu, Coimbatore, 641 043, India; Pechimuthu C., Department of Zoology, School of Biosciences, Avinashilingam Institute for Home Science and Higher Education for Women, Tamil Nadu, Coimbatore, 641 043, India; Pappuswamy M., Department of Life Science, CHRIST University, Karnataka, Bengaluru, 560076, India; Balasubramanian B., Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, 05006, South Korea

Perovskite photosupercapacitors: Next generation powerpacks integrating solar cells and supercapacitors
subject: Energy storage and harvesting; Integrated devices; Perovskite solar cells; Photosupercapacitors; Supercapacitors
description: As solar energy is intermittent, it must be stored in addition to being harvested, opening one of the most potential areas for powering future technology. The devices that have the ability to collect and store energy are called Photosupercapacitors. Owing to their dual purpose, photosupercapacitors are gaining increasing attention as potential components for emerging wearable and portable electronics. These devices have advanced significantly; among them, Perovskite-based Photosupercapacitors have reported greater efficiency so far. When required, this integrated device, which consists of a perovskite solar cell unit and a supercapacitor, can supply reliable off-grid power to external loads and charge itself in an illuminated space. This review primarily focuses on various types of Perovskite-based Photosupercapacitors that have emerged so far, significantly discussing the choice of material for each layer, the technique of connecting the solar cell and supercapacitor, the performance of each part, and the overall powerpack performance. The present review gives a broad outlook on challenges and future perspectives involved in the development of these devices. We believe that this review would provide a valid account of the current developments and future scopes for developing portable, highly efficient Perovskite-based Photosupercapacitors with less toxicity and admissible stability. 2024 Elsevier Ltd
creator: Alex S.; George J.; Balachandran M.
source: Journal of Energy Storage, Vol-103
publisher: Elsevier Ltd
date: 2024-01-01
rights: Restricted Access
relation: ISSN: 2352152X
format: Online
language: English
type: Review
coverage: Alex S., Department of Physics and Electronics, Christ University, Karnataka, Bengaluru, India; George J., Department of Physics and Electronics, Christ University, Karnataka, Bengaluru, India; Balachandran M., Department of Physics and Electronics, Christ University, Karnataka, Bengaluru, India

Phyto- and zoomass-derived nanostructured carbon as efficient catalysts for oxygen reduction reaction in fuel cells: a review
description: Abstract: The oxygen reduction reaction (ORR) plays a pivotal role in several energy storage and conversion technologies, including metal-air batteries, microbial fuel cells, and low-temperature hydrogen and alcohol fuel cells. Fuel cells, in particular, have gained significant traction as a feasible alternative energy source due to their efficiency, cleanliness, adaptability, and ability to reuse exhaust heat. However, the complex nature of ORR requires highly efficient electrocatalysts for optimal fuel cell performance. While Pt-based electrocatalysts are widely regarded as the most suitable for both the cathode and anode in fuel cells, their high cost, scarcity, and susceptibility to fuel crossover have driven the search for alternative ORR catalysts. In this context, carbon materials have emerged as promising candidates due to their low cost, long-term stability, and strong electrocatalytic activity. Recent advancements in biomass-derived carbon nanostructures align with the global push for sustainable energy and a pollution-free environment. This review examines carbon structures derived from the carbonization of plant and animal biomass and evaluates their performance as noble metal supports, non-noble metal electrocatalysts, and metal-free electrocatalysts for ORR. Graphical abstract: (Figure presented.) The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
creator: Toms S.; S Nair A.; Parnika P.; Mathew E.M.; Jafri R.I.
source: Journal of Materials Science, Vol-59, No. 46, pp. 21191-21221.
publisher: Springer
date: 2024-01-01
rights: Restricted Access
relation: ISSN: 222461; CODEN: JMTSA
format: Online
language: English
type: Review
coverage: Toms S., Department of Physics & amp; Electronics, CHRIST (Deemed to be University), Bangalore, 560029, India; S Nair A., Department of Physics & amp; Electronics, CHRIST (Deemed to be University), Bangalore, 560029, India; Parnika P., Department of Physics & amp; Electronics, CHRIST (Deemed to be University), Bangalore, 560029, India; Mathew E.M., Department of Physics & amp; Electronics, CHRIST (Deemed to be University), Bangalore, 560029, India; Jafri R.I., Department of Physics & amp; Electronics, CHRIST (Deemed to be University), Bangalore, 560029, India

An extensive review on transition metal catalyzed indole C[sbnd]H activation: Catalyst selection and mechanistic insights
subject: Antiviral drugs; Catalyst; CH activation of indoles; Iridium; Palladium; Rhodium; Ruthenium and manganese
description: The present review article explores the expansive synthetic methodologies facilitated by C[sbnd]H activation of indoles using transition metal catalysts. The strategic utilization of catalysts such as palladium, rhodium, iridium, ruthenium, and manganese has revolutionized organic synthesis by enabling selective alkynylation, acylation, and annulation reactions. These transformations are pivotal in pharmaceuticals, particularly in the synthesis of antihistamines and potential antiviral drugs against SARS-CoV-2. Additionally, these catalysts play a crucial role in perfumery and other chemical industries, enhancing the efficiency and precision of compound synthesis. The choice of transition metal catalysts is informed by their affordability and compatibility with both traditional analytical methods and innovative techniques like microwave synthesis and LED irradiation. Furthermore, this review underscores the interdisciplinary impact of transition metal-catalyzed C[sbnd]H activation on indoles, highlighting its significance in advancing both fundamental organic chemistry and applied sciences essential for modern technological advancements and drug discovery efforts. 2024 The Author(s)
creator: Ann Mary C.J.; Vasudevan D.; Nagarajan P.; Suhas S.; Vijayan A.; Radhakrishnan K.V.; Sudhakar Y.N.
source: Polyhedron, Vol-264
publisher: Elsevier Ltd
date: 2024-01-01
rights: All Open Access; Hybrid Gold Open Access
relation: ISSN: 2775387; CODEN: PLYHD
format: Online
language: English
type: Review
coverage: Ann Mary C.J., Department of Chemistry, Christ University, Hosur Road, Karnataka, Bengaluru, 560029, India; Vasudevan D., Department of Chemistry, Christ University, Hosur Road, Karnataka, Bengaluru, 560029, India; Nagarajan P., Department of Chemistry, Christ University, Hosur Road, Karnataka, Bengaluru, 560029, India; Suhas S., Department of Chemistry, Christ University, Hosur Road, Karnataka, Bengaluru, 560029, India; Vijayan A., Department of Chemistry, Christ University, Hosur Road, Karnataka, Bengaluru, 560029, India; Radhakrishnan K.V., CSIR- National Institute for Interdisciplinary Science and Technology, Industrial Estate P. O., Thiruvananthapuram, 695019, India; Sudhakar Y.N., Department of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education, Karnataka, Manipal, 576104, India

Biotechnological approaches for the production of camptothecin
subject: Camptotheca acuminata; Camptothecin; Extraction; In vitro production; NothapodytesNimmoniana; Quantification
description: Abstract: Camptothecin (CPT), an indole alkaloid popular for its anticancer property, is considered the third most promising drug after taxol and famous alkaloids from Vinca for the treatment of cancer in humans. Camptothecin was first identified in Camptotheca acuminata followed by several other plant species and endophytic fungi. Increased harvesting driven by rising global demand is depleting the availability of elite plant genotypes, such as Camptotheca acuminata and Nothapodytes nimmoniana, crucial for producing alkaloids used in treating diseases like cancer. Conservation of these genotypes for the future is imperative. Therefore, research on different plant tissue culture techniques such as cell suspension culture, hairy roots, adventitious root culture, elicitation strategies, and endophytic fungi has been adopted for the production of CPT to meet the increasing demand without affecting the source plants existence. Currently, another strategy to increase camptothecin yield by genetic manipulation is underway. The present review discusses the plants and endophytes that are employed for camptothecin production and throws light on the plant tissue culture techniques for the regeneration of plants, callus culture, and selection of cell lines for the highest camptothecin production. The review further explains the simple, accurate, and cost-effective extraction and quantification methods. There is enormous potential for the sustainable production of CPT which could be met by culturing of suitable endophytes or plant cell or organ culture in a bioreactor scale production. Also, different gene editing tools provide opportunities for engineering the biosynthetic pathway of CPT, and the overall CPT production can be improved. Key points: Camptothecin is a naturally occurring alkaloid with potent anticancer properties, primarily known for its ability to inhibit DNA topoisomerase I. Plants and endophytes offer a potential approach for camptothecin production. Biotechno…
creator: Banadka A.; Narasimha S.W.; Dandin V.S.; Naik P.M.; Vennapusa A.R.; Melmaiee K.; Vemanna R.S.; Al-Khayri J.M.; Thiruvengadam M.; Nagella P.
source: Applied Microbiology and Biotechnology, Vol-108, No. 1
publisher: Springer Science and Business Media Deutschland GmbH
date: 2024-01-01
rights: All Open Access; Green Open Access; Hybrid Gold Open Access
relation: ISSN: 1757598; PubMed ID: 38896329; CODEN: AMBID
format: Online
language: English
type: Review
coverage: Banadka A., Department of Life Sciences, CHRIST (Deemed to be University), Karnataka, Bangalore, 560 029, India; Narasimha S.W., Department of Life Sciences, CHRIST (Deemed to be University), Karnataka, Bangalore, 560 029, India; Dandin V.S., Department of Biology, JSS College, Dharwad, India; Naik P.M., Department of Botany, Karnatak University, Karnataka, Dharwad, 580003, India; Vennapusa A.R., Department of Agriculture and Natural Resources, Delaware State University, Dover, 19901, DE, United States; Melmaiee K., Department of Agriculture and Natural Resources, Delaware State University, Dover, 19901, DE, United States; Vemanna R.S., Laboratory of Plant Functional Genomics, Regional Center for Biotechnology, Haryana, Faridabad, 121001, India; Al-Khayri J.M., Department of Agricultural Biotechnology, College of Agriculture and Food Sciences, King Faisal University, Al- Ahsa, 31982, Saudi Arabia; Thiruvengadam M., Department of Crop Science, College of Sanghuh Life Science, Konkuk University, Seoul, South Korea; Nagella P., Department of Life Sciences, CHRIST (Deemed to be University), Karnataka, Bangalore, 560 029, India

Cinnamon A Competent Drug: A Review on Extraction, Analysis and Anticancer Action
subject: Anticancer; Apoptosis; Cinnamon; Extraction; Microwave-assisted analysis
description: Cinnamon, an Indigenous species, is extensively used as a folk medicine in India, China, and other parts of the world due to its therapeutic potential inherited via the latent chemical composition. The vital component presented is cinnamaldehyde, along with cinnamic acid and cinnamate, which contributes to being an anti-inflammatory, antimicrobial, antidiabetic, and anticancer agent together with the capability to control neurological syndromes like Alzheimer's and even Parkinson's diseases. Given the importance of the anticarcinogenic properties of cinnamon on various cell strains concerning the curable effect, this review focuses on evaluating different extraction methods like steam distillation, Soxhlet extraction, microwave-assisted extraction, and more, in addition to a summary of new technologies like gas chromatography, HPLC, DART-MS, and NMR, etc. which paved the way in characterizing the chemical composition of cinnamon. Cinnamaldehyde showed its apoptosis through various mechanistic pathways on an adequate number of cell lines and antineoplastic potential on specific multifaceted cancerous cells, which advocates for continued research and investment in this vital area of drug discovery and suggestions for future scope. 2024 Wiley-VCH GmbH.
creator: Demina T.D.; Margaret Rodrigues R.; George L.; Varghese A.
source: ChemistrySelect, Vol-9, No. 41
publisher: John Wiley and Sons Inc
date: 2024-01-01
rights: Restricted Access
relation: ISSN: 23656549
format: Online
language: English
type: Review
coverage: Demina T.D., Department of Chemistry, CHRIST University, Hosur Road, Karnataka, Bengaluru, 560029, India; Margaret Rodrigues R., Department of Chemistry, CHRIST University, Hosur Road, Karnataka, Bengaluru, 560029, India, Department of Chemistry, St Agnes College (Autonomous), Karnataka, Mangaluru, 575002, India; George L., Department of Chemistry, CHRIST University, Hosur Road, Karnataka, Bengaluru, 560029, India; Varghese A., Department of Chemistry, CHRIST University, Hosur Road, Karnataka, Bengaluru, 560029, India

Epigenetic Mechanisms Induced by Mycobacterium tuberculosis to Promote Its Survival in the Host
subject: apoptosis; autophagy; epigenetics; macrophage polarization; miRNA modification; tuberculosis
description: Tuberculosis caused by the obligate intracellular pathogen, Mycobacterium tuberculosis, is one among the prime causes of death worldwide. An urgent remedy against tuberculosis is of paramount importance in the current scenario. However, the complex nature of this appalling disease contributes to the limitations of existing medications. The quest for better treatment approaches is driving the research in the field of host epigenomics forward in context with tuberculosis. The interplay between various host epigenetic factors and the pathogen is under investigation. A comprehensive understanding of how Mycobacterium tuberculosis orchestrates such epigenetic factors and favors its survival within the host is in increasing demand. The modifications beneficial to the pathogen are reversible and possess the potential to be better targets for various therapeutic approaches. The mechanisms, including histone modifications, DNA methylation, and miRNA modification, are being explored for their impact on pathogenesis. In this article, we are deciphering the role of mycobacterial epigenetic regulators on various strategies like cytokine expression, macrophage polarization, autophagy, and apoptosis, along with a glimpse of the potential of host-directed therapies. 2024 by the authors.
creator: Thomas S.S.; Abhinand K.; Menon A.M.; Nair B.G.; Kumar G.B.; Arun K.B.; Edison L.K.; Madhavan A.
source: International Journal of Molecular Sciences, Vol-25, No. 21
publisher: Multidisciplinary Digital Publishing Institute (MDPI)
date: 2024-01-01
rights: All Open Access; Gold Open Access
relation: ISSN: 16616596; PubMed ID: 39519352
format: Online
language: English
type: Review
coverage: Thomas S.S., School of Biotechnology, Amrita Vishwa Vidyapeetham, AmritapuriKerala, Kollam, 690525, India; Abhinand K., School of Biotechnology, Amrita Vishwa Vidyapeetham, AmritapuriKerala, Kollam, 690525, India; Menon A.M., School of Biotechnology, Amrita Vishwa Vidyapeetham, AmritapuriKerala, Kollam, 690525, India; Nair B.G., School of Biotechnology, Amrita Vishwa Vidyapeetham, AmritapuriKerala, Kollam, 690525, India; Kumar G.B., School of Biotechnology, Amrita Vishwa Vidyapeetham, AmritapuriKerala, Kollam, 690525, India; Arun K.B., Department of Life Sciences, CHRIST (Deemed to be University), Karnataka, Bangalore, 560029, India; Edison L.K., Department of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, 32610, FL, United States; Madhavan A., School of Biotechnology, Amrita Vishwa Vidyapeetham, AmritapuriKerala, Kollam, 690525, India

Heterogeneous Catalysis in the Synthesis of Nitrogen-Containing Heterocyclics
subject: Heterocyclic compounds; Heterogenous catalysts; Organic synthesis; Reactivity
description: The synthesis of nitrogen-containing heterocyclic compounds using heterogeneous catalysis is a topic of significant interest in organic synthesis and chemical research. Heterogeneous catalysis offers several advantages over homogeneous catalysis, including easier separation and recovery of the catalyst, reduced waste generation, and potentially higher stability and reusability. In this review, the pivotal role of heterogeneous catalysis in synthesizing nitrogen-containing heterocyclic compounds is explored. Various types of heterocycles and the specific applications of these compounds in drug discovery and material development are discussed in detail. This review discusses various examples of heterogeneous catalysts employed in the synthesis of nitrogen-containing heterocycles, including metal oxides, supported metals, metal nanoparticles, zeolites, and other porous materials. Emphasis is placed on the mechanistic insights and reaction pathways facilitated by different catalysts. Additionally, recent advancements and innovations in the field are discussed, including novel catalyst designs, green chemistry approaches, and emerging trends in catalytic materials. The aim is to provide a comprehensive overview of the impact and potential of heterogeneous catalysis in this important area of organic synthesis. 2024 Wiley-VCH GmbH.
creator: Rajendran A.; Anand S.; Sunajadevi K.R.P.; Pinheiro D.; Chundattu S.J.
source: ChemistrySelect, Vol-9, No. 41
publisher: John Wiley and Sons Inc
date: 2024-01-01
rights: Restricted Access
relation: ISSN: 23656549
format: Online
language: English
type: Review
coverage: Rajendran A., Department of Chemistry, Christ University, Karnataka, Bengaluru, 560029, India; Anand S., Department of Chemistry, Christ University, Karnataka, Bengaluru, 560029, India; Sunajadevi K.R.P., Department of Chemistry, Christ University, Karnataka, Bengaluru, 560029, India; Pinheiro D., Department of Chemistry, Christ University, Karnataka, Bengaluru, 560029, India; Chundattu S.J., Department of Sciences and Humanities, Christ University, Karnataka, Bengaluru, 560076, India

Integrating dye-sensitized solar cells and supercapacitors: portable powerpacks for future energy applications
description: Integrating energy storage and harvesting devices have been major challenges and significant needs of the time for upcoming energy applications. Photosupercapacitors are combined solar cell-supercapacitor devices which can provide next-generation portable powerpacks. Owing to advantages like economic and environmental friendliness, dye-sensitized solar cells (DSSCs) offer vast potential for being integrated with energy accumulation devices like supercapacitors. Over the past few years, various types of harvesting cum storage power devices combining DSSCs and supercapacitors have been reported. Over time the devices have improved in both performance and stability providing a broad outlook to possible future advancements including commercialization. We still have many challenges that are yet to be resolved in order to take these powerpacks to the next level of applications in portable and wearable electronics and communication devices. In this context, a detailed analysis and comparison of already reported photo-powered integrated supercapacitors based on DSSCs would give further insights into future advancements. In this review, we have discussed the development of photosupercapacitors, their fabrication strategies, and different materials used as counter electrodes, electrolytes, and dye sensitizers. Graphical Abstract: (Figure presented.) The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
creator: Davis J.K.; George J.; Balachandran M.
source: Journal of Materials Science, Vol-59, No. 43, pp. 20176-20203.
publisher: Springer
date: 2024-01-01
rights: Restricted Access
relation: ISSN: 222461; CODEN: JMTSA
format: Online
language: English
type: Review
coverage: Davis J.K., Department of Physics and Electronics, Christ University, Karnataka, Bengaluru, India; George J., Department of Physics and Electronics, Christ University, Karnataka, Bengaluru, India; Balachandran M., Department of Physics and Electronics, Christ University, Karnataka, Bengaluru, India

Heavy metal ion sensing strategies using fluorophores for environmental remediation
subject: Analytical techniques; Biological fluorophores; Environmental issues; Heavy metal ions; Organic dyes; Quantum dots
description: The main aim of this review is to provide a holistic summary of the latest advances within the research area focusing on the detection of heavy metal ion pollution, particularly the sensing strategies. The review explores various heavy metal ion detection approaches, encompassing spectrometry, electrochemical methods, and optical techniques. Numerous initiatives have been undertaken in recent times in response to the increasing demand for fast, sensitive, and selective sensors. Notably, fluorescent sensors have acquired prominence owing to the numerous advantages such as good specificity, reversibility, and sensitivity. Further, this review also explores the advantages of various nanomaterials employed in sensing heavy metal ions. In this regard, exclusive emphasis is placed on fluorescent nanomaterials based on organic dyes, quantum dots, and fluorescent aptasensors for metal ion removal from aqueous systems, and to identify the fate of heavy metal ions in the natural environment. 2024
creator: Shanmugavel A.; Rene E.R.; Balakrishnan S.P.; Krishnakumar N.; Jose S.P.
source: Environmental Research, Vol-260
publisher: Academic Press Inc.
date: 2024-01-01
rights: Restricted Access
relation: ISSN: 139351; PubMed ID: 38969312; CODEN: ENVRA
format: Online
language: English
type: Review
coverage: Shanmugavel A., School of Physics, Madurai Kamaraj University, Tamil Nadu, Madurai, 625021, India; Rene E.R., Department of Water Supply, Sanitation and Environmental Engineering, IHE Delft Institute for Water Education, Westvest 7, 2601DA, Delft, Netherlands; Balakrishnan S.P., Department of Chemistry, CHRIST (Deemed to Be University), Karnataka, Bengaluru, 560029, India; Krishnakumar N., School of Physics, Madurai Kamaraj University, Tamil Nadu, Madurai, 625021, India; Jose S.P., School of Physics, Madurai Kamaraj University, Tamil Nadu, Madurai, 625021, India

Updated aspects of alpha-Solanine as a potential anticancer agent: Mechanistic insights and future directions
subject: anticancer mechanisms; apoptosis; glycoalkaloids; Solanaceae; ?-Solanine
description: Cancer remains a critical global health challenge, with limited progress in reducing mortality despite advancements in diagnosis and treatment. The growing resistance of tumors to existing chemotherapy exacerbates this burden. In response, the search for new anticancer compounds from plants has intensified, given their historical success in yielding effective treatments. This review focuses on ?-solanine, a glycoalkaloid primarily derived from potato tubers and nightshade family plants, recognized for its diverse biological activities, including anti-allergic, antipyretic, anti-inflammatory, anti-diabetic, and antibiotic properties. Recently, ?-solanine has gained attention as a potential anticancer agent. Utilizing resources like PubMed/MedLine, ScienceDirect, Web of Science, Scopus, the American Chemical Society, Google Scholar, Springer Link, Wiley, and various commercial websites, this review consolidates two decades of research on ?-solanine's anticancer effects and mechanisms against nine different cancers, highlighting its role in modulating various signaling pathways. It also discusses ?-solanine's potential as a lead compound in cancer therapy. The abundant availability of potato peel, often discarded as waste or sold cheaply, is suggested as a sustainable source for large-scale ?-solanine extraction. The study concludes that ?-solanine holds promise as a standalone or adjunctive cancer treatment. However, further research is necessary to optimize this lead compound and mitigate its toxicity through various strategies. 2024 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.
creator: Nandi S.; Sikder R.; Nag A.; Khatua S.; Sen S.; Chakraborty N.; Naskar A.; Zhakipbekov K.; Acharya K.; Habtemariam S.; ArslanAte??ahin D.; Goloshvili T.; AhmedAldahish A.; Sharifi-Rad J.; Calina D.
source: Food Science and Nutrition, Vol-12, No. 10, pp. 7088-7107.
publisher: John Wiley and Sons Inc
date: 2024-01-01
rights: All Open Access; Green Open Access; Hybrid Gold Open Access
relation: ISSN: 20487177
format: Online
language: English
type: Review
coverage: Nandi S., Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, Kolkata, India; Sikder R., Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, Kolkata, India; Nag A., Department of Life Sciences, CHRIST (Deemed to be University), Karnataka, Bangalore, India; Khatua S., Department of Botany, Faculty of Science, University of Allahabad, Uttar Pradesh, Prayagraj, India; Sen S., Department of Botany, Fakir Chand College, Kolkata, India; Chakraborty N., Department of Botany, Scottish Church College, Kolkata, India; Naskar A., Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, Kolkata, India; Zhakipbekov K., Department of Organization and Management and Economics of Pharmacy and Clinical Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan; Acharya K., Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, Kolkata, India; Habtemariam S., Pharmacognosy Research & Herbal Analysis Services UK, Kent, United Kingdom; ArslanAte??ahin D., Department of Plant and Animal Production, Baskil Vocational School, F?rat University, Elaz?g, Turkey; Goloshvili T., Department of Plant Physiology and Genetic Resources, Institute of Botany, Ilia State University, Tbilisi, Georgia; AhmedAldahish A., Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia; Sharifi-Rad J., Department of Biomedical Sciences, College of Medicine, Korea University, Seoul, South Korea; Calina D., Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania

Harnessing transition metal oxide?carbon heterostructures: Pioneering electrocatalysts for energy systems and other applications
subject: Batteries; Composites; HER; OER; Supercapacitors; Transition metal oxides
description: Exponential demand for energy resources and fossil fuel substitution with green alternatives are essential to bringing sustainable development and a solution to the energy crisis. Transition metal oxides (TMOs) and their composites (TMOCs) as promising electrocatalysts to develop potential energy conversion and storage devices contribute to the solution to this crisis. The productivity of green fuels such as hydrogen from water-splitting reactions, the efficiency of energy storage and harvesting devices including supercapacitors and batteries, and the performance of electrochemical sensors can be remarkably enhanced with TMOs and their composites. Excellent electrochemical attributes, stability, abundant reserves, low cost, environment-friendly, and low toxicity make TMOs and their composites an excellent choice. The tunability of the physical and chemical properties of TMOs makes them attractive for research in designing different energy storage devices. This review presents a concise overview of the unique physical and electrochemical aspects of various TMOs and TMOCs, such as spinels, perovskites, and TMO-integrated carbon-based compounds, and their relevance for specific applications, emphasizing energy-related fields. The recent research advancements of TMOs-based functional materials for emerging applications, such as water splitting, fuel cells, supercapacitors, batteries, and sensing, are discussed. This review also highlights the advantageous properties and pertinent fabrication methods of TMOs and TMOCs for electrocatalysis, along with the methods to enhance their electrocatalytic abilities, which improve the overall efficiency of the desired applications. 2024
creator: Merlin V S M.; Sariga; Jose S.; Varghese A.
source: Journal of Energy Storage, Vol-99
publisher: Elsevier Ltd
date: 2024-01-01
rights: Restricted Access
relation: ISSN: 2352152X
format: Online
language: English
type: Review
coverage: Merlin V S M., Department of Chemistry, Christ University, Bengaluru, 560029, India; Sariga, Department of Chemistry, Christ University, Bengaluru, 560029, India; Jose S., Department of Chemistry, Christ University, Bengaluru, 560029, India; Varghese A., Department of Chemistry, Christ University, Bengaluru, 560029, India