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Environmental Pollutants as Emerging Concerns for Cardiac Diseases: A Review on Their Impacts on Cardiac Health
Comorbidities related to cardiovascular disease (CVD) and environmental pollution have emerged as serious concerns. The exposome concept underscores the cumulative impact of environmental factors, including climate change, air pollution, chemicals like PFAS, and heavy metals, on cardiovascular health. Chronic exposure to these pollutants contributes to inflammation, oxidative stress, and endothelial dysfunction, further exacerbating the global burden of CVDs. Specifically, carbon monoxide (CO), ozone, particulate matter (PM2.5), nitrogen dioxide (NO2), sulfur dioxide (SO2), heavy metals, pesticides, and micro- and nanoplastics have been implicated in cardiovascular morbidity and mortality through various mechanisms. PM2.5 exposure leads to inflammation and metabolic disruptions. Ozone and CO exposure induce oxidative stress and vascular dysfunction. NO2 exposure contributes to cardiac remodeling and acute cardiovascular events, and sulfur dioxide and heavy metals exacerbate oxidative stress and cellular damage. Pesticides and microplastics pose emerging risks linked to inflammation and cardiovascular tissue damage. Monitoring and risk assessment play a crucial role in identifying vulnerable populations and assessing pollutant impacts, considering factors like age, gender, socioeconomic status, and lifestyle disorders. This review explores the impact of cardiovascular disease, discussing risk-assessment methods, intervention strategies, and the challenges clinicians face in addressing pollutant-induced cardiovascular diseases. It calls for stronger regulatory policies, public health interventions, and green urban planning. 2025 by the authors. -
Microbial engineering strategies for synthetic microplastics clean up: A review on recent approaches
Microplastics are the small fragments of the plastic molecules which find their applications in various routine products such as beauty products. Later, it was realized that it has several toxic effects on marine and terrestrial organisms. This review is an approach in understanding the microplastics, their origin, dispersal in the aquatic system, their biodegradation and factors affecting biodegradation. In addition, the paper discusses the major engineering approaches applied in microbial biotechnology. Specifically, it reviews microbial genetic engineering, such as PET-ase engineering, MHET-ase engineering, and immobilization approaches. Moreover, the major challenges associated with the plastic removal are presented by evaluating the recent reports available. 2022 Elsevier B.V. -
Synthesis and characterization of chitosan nanofibers for wound healing and drug delivery application
Chitosan has emerged as a biodegradable, absorbable, non-toxic, biocompatible biopolymer for wound healing and drug delivery applications. Chitosan can be converted to nanofibers which have higher potential for wound healing and drug delivery applications as compared to chitosan nanoparticles and nanocomposites. Due to these properties chitosan nanofiber has emerged as a promising candidate for biomedical research. In the recent decades it has been observed that several studies reported about the production and medical applications of chitosan nanofibers. Although, preparation and application of chitosan nanofibers is easy. But there are several challenges and bottlenecks associated with its practical application and large-scale production. The presented review is a comprehensive discussion on the major challenges and bottlenecks associated with chitosan nanofibers synthesis and their practical applications in biomedical research. It discusses critically about the issues related to the chitosan nanofibers solubility, stability, mechanical strength, absorption and drug release properties, and its scale up hinderances. Moreover, the review presents an insight into the future recommendations on considering the parameters associated for development of an efficient, sustainable, and promising biopolymer. 2023 Elsevier B.V. -
Lignocellulosic biomass for biochar production: A green initiative on biowaste conversion for pharmaceutical and other emerging pollutant removal
Lignocellulosic waste generation and their improper disposal has accelerated the problems associated with increased greenhouse gas emissions and associated environmental pollution. Constructive ways to manage and mitigate the pollution associated with lignocellulosic waste has propelled the research on biochar production using lignocellulose-based substrates. The sustainability of various biochar production technologies in employing lignocellulosic biomass as feedstock for biochar production not only aids in the lignocellulosic biomass valorization but also helps in carbon neutralization and carbon utilization. Functionalization of biochar through various physicochemical methods helps in improving their functional properties majorly by reducing the size of the biochar particles to nanoscale and modifying their surface properties. The usage of engineered biochar as nano adsorbents for environmental applications like dye absorption, removal of organic pollutants and endocrine disrupting compounds from wastewater has been the thrust areas of research in the past few decades. This review presents a comprehensive outlook on the up-to-date research findings related to the production and engineering of biochar from lignocellulosic biomass and their applications in environmental remediation especially with respect to wastewater treatment. Further a detailed discussion on various biochar activation methods and the future scope of biochar research is presented in this review work. 2024 Elsevier Ltd -
Toxicity analysis of endocrine disrupting pesticides on non-target organisms: A critical analysis on toxicity mechanisms
Endocrine disrupting compounds are the chemicals which mimics the natural endocrine hormones and bind to the receptors made for the hormones. Upon binding they activate the cascade of reaction which leads to permanent activating of the signalling cycle and ultimately leads to uncontrolled growth. Pesticides are one of the endocrine disrupting chemicals which cause cancer, congenital birth defects, and reproductive defects in non-target organisms. Non-target organisms are keen on exposing to these pesticides. Although several studies have reported about the pesticide toxicity. But a critical analysis of pesticide toxicity and its role as endocrine disruptor is lacking. Therefore, the presented review literature is an endeavour to understand the role of the pesticides as endocrine disruptors. In addition, it discusses about the endocrine disruption, neurological disruption, genotoxicity, and ROS induced pesticide toxicity. Moreover, biochemical mechanisms of pesticide toxicity on non-target organisms have been presented. An insight on the chlorpyrifos toxicity on non-target organisms along with species names have been presented. 2023 Elsevier Inc. -
Micropollutants characteristics, fate, and sustainable removal technologies for landfill leachate: A technical perspective
Waste disposal in landfills has gained momentum in the last few decades as it is one among the easy and cost-effective method for waste management for the accelerating global population. Heterogenous nature of the waste ending up in landfills makes it difficult to predict the fate of these pollutants making it difficult for its biomonitoring and specific treatment. Among the major issues associated with landfill treatment, liquid percolation from this heterogenous waste substrate collectively referred as leachate poses the greater risk to environment through soil and ground water pollution. The diversity of micropollutants presents in landfill leachates ranging from microbial pathogens, pesticides, microplastics, pharmaceuticals and other harmful chemicals calls for crucial attention towards improving methods used for their treatment and removal. This review summarizes the key components of landfill leachates with specific emphasize on micropollutant content of leachate. Further the features of most recent and advanced technologies that were successfully explored for micropollutant removal from landfill leachates are presented in this review. 2023 Elsevier Ltd -
Microplastics in food: Occurrence, toxicity, green analytical detection methods and future challenges
The pervasive presence of microplastics (MPs) in the environment has raised significant concerns about their infiltration into the human food chain. In current review, the occurrence and distribution of MPs in various food matrices such as seafood, drinking water, fruits, vegetables, and beverages are discussed along with their potential routes of MPs entry into the human food chain. The toxicity of MPs on human health and different organs are discussed in brief. Current technological advancement and green analytical methods for the detection of MPs in food samples are compared, discussing their advantages and limitations. Green analytical methods, including stereomicroscopy, Fourier Transform Infrared spectroscopy, Raman spectroscopy, and enzymatic digestion, are evaluated for their efficacy and environmental impact. The Analytical Eco-Scale is used to assess the greenness of these methods. Challenges associated with MPs detection in food, such as complex food matrices, pretreatment methods, and variability in MPs concentrations, are addressed. 2024 The Author(s) -
Emerging challenges for the agro-industrial food waste utilization: A review on food waste biorefinery
Modernization and industrialization has undoubtedly revolutionized the food and agro-industrial sector leading to the drastic increase in their productivity and marketing thereby accelerating the amount of agro-industrial food waste generated. In the past few decades the potential of these agro-industrial food waste to serve as bio refineries for the extraction of commercially viable products like organic acids, biochemical and biofuels was largely discussed and explored over the conventional method of disposing in landfills. The sustainable development of such strategies largely depends on understanding the techno economic challenges and planning for future strategies to overcome these hurdles. This review work presents a comprehensive outlook on the complex nature of agro-industrial food waste and pretreatment methods for their valorization into commercially viable products along with the challenges in the commercialization of food waste bio refineries that need critical attention to popularize the concept of circular bio economy. 2022 -
Commercialization potential of PET (polyethylene terephthalate) recycled nanomaterials: A review on validation parameters
Polyethylene Terephthalate (PET) is a polymer which is considered as one of the major contaminants to the environment. The PET waste materials can be recycled to produce value-added products. PET can be converted to nanoparticles, nanofibers, nanocomposites, and nano coatings. To extend the applications of PET nanomaterials, understanding its commercialization potential is important. In addition, knowledge about the factors affecting recycling of PET based nanomaterials is essential. The presented review is focused on understanding the PET commercialization aspects, keeping in mind market analysis, growth drivers, regulatory affairs, safety considerations, issues associated with scale-up, manufacturing challenges, economic viability, and cost-effectiveness. In addition, the paper elaborates the challenges associated with the use of PET based nanomaterials. These challenges include PET contamination to water, soil, sediments, and human exposure to PET nanomaterials. Moreover, the paper discusses in detail about the factors affecting PET recycling, commercialization, and circular economy with specific emphasis on life cycle assessment (LCA) of PET recycled nanomaterials. 2024 Elsevier Ltd -
Origin, ecotoxicity, and analytical methods for microplastic detection in aquatic systems
Over the decades, interaction of microplastics with other pollutants in a dynamic environmental set up was observed to increase their toxic effects. This scenario is worse in aquatic environments due to the entry of huge loads of microplastic components into the waterbodies through direct plastic dumping and those delivered from effluents originating from various treatment plants. Although extensive research was done to understand the issue associated with microplastic contamination of various aquatic environments, a huge research gap still exists in areas like their ecotoxicology, fate, distribution, and detection methods in aquatic environments. Moreover, the combined deleterious effect of microplastics in association with other environmental pollutants is not widely studied and requires more research focus. The major scope of this review is to present a comprehensive outlook on the recent studies carried out to understand the types, origin, distribution, transport, fate, and toxicity of microplastics in aquatic environments, both fresh water and marine. The review summarizes the ecotoxicological effects of microplastic contaminants in aquatic environment like the oxidative damage, neurotoxicity and decreased reproductive potential. An in-depth discussion regarding the ability of the microplastics in combination with other pollutants to serve as potentially hazardous agents in aquatic environment is also elaborated in the review. Further a summary on various microplastic detection methods, challenges associated with microplastic detection and management is carefully reviewed and compiled in this work. The need for proper awareness programs to general public highlighting the toxicity of microplastics and strict regulations regarding their continuous assessment and management in waterbodies are essential factors in controlling their adverse effect on aquatic environment. 2023 Elsevier B.V. -
A Retrospection on Mercury Contamination, Bioaccumulation, and Toxicity in Diverse Environments: Current Insights and Future Prospects
Owing to various industrial applications of mercury (Hg), its release into the environment at high concentration is becoming a great threat to living organisms on a global scale. Human exposure to Hg is greatly correlated with contamination in the food chain through cereal crops and sea foods. Since Hg is a non-essential component and does not possess a biological role and exhibits carcinogenic and genotoxic behaviour, biomonitoring with a focus on biomagnification of higher living animals and plants is the need of the hour. This review traces the plausible relationship between Hg concentration, chemical form, exposure, bioavailability, bioaccumulation, distribution, and ecotoxicology. The toxicity with molecular mechanisms, oxidative stress (OS), protein alteration, genomic change, and enzymatic disruptions are discussed. In addition, this review also elaborates advanced strategies for reducing Hg contamination such as algal and phytoremediation, biochar application, catalytical oxidation, and immobilization. Furthermore, there are challenges to overcome and future perspectives considering Hg concentrations, biomarkers, and identification through the nature of exposures are recommended. 2023 by the authors. -
Bioengineering of biowaste to recover bioproducts and bioenergy: A circular economy approach towards sustainable zero-waste environment
The inevitable need for waste valorisation and management has revolutionized the way in which the waste is visualised as a potential biorefinery for various product development rather than offensive trash. Biowaste has emerged as a potential feedstock to produce several value-added products. Bioenergy generation is one of the potential applications originating from the valorisation of biowaste. Bioenergy production requires analysis and optimization of various parameters such as biowaste composition and conversion potential to develop innovative and sustainable technologies for most effective utilization of biowaste with enhanced bioenergy production. In this context, feedstocks, such as food, agriculture, beverage, and municipal solid waste act as promising resources to produce renewable energy. Similarly, the concept of microbial fuel cells employing biowaste has clearly gained research focus in the past few decades. Despite of these potential benefits, the area of bioenergy generation still is in infancy and requires more interdisciplinary research to be sustainable alternatives. This review is aimed at analysing the bioconversion potential of biowaste to renewable energy. The possibility of valorising underutilized biowaste substrates is elaborately presented. In addition, the application and efficiency of microbial fuel cells in utilizing biowaste are described in detail taking into consideration of its great scope. Furthermore, the review addresses the significance bioreactor development for energy production along with major challenges and future prospects in bioenergy production. Based on this review it can be concluded that bioenergy production utilizing biowaste can clearly open new avenues in the field of waste valorisation and energy research. Systematic and strategic developments considering the techno economic feasibilities of this excellent energy generation process will make them a true sustainable alternative for conventional energy sources. 2023 Elsevier Ltd -
An Integration of Satellite A Based Network with Higher Level Type Network with the use of P-P Connection: A Deep Review
The Aerial Access 6g Network (AAN) is seen as a way to access remote and sparsely populated areas not served by traditional terrestrial networks, especially with the advent of 6G technology. This study presents a new approach for efficient data collection and transmission in point to point access networks using low earth orbit (LEO) satellites and high altitude platforms (HAPS). Incorporating LEO satellites as backlinks and HAPs as airborne base stations, the system provides low-bandwidth transmission to ground users. A Time Augmented Graph (TEG) model is proposed to represent the dynamic topology of the air access network according to time slots. With this example, this study can create an entire programming problem with the goal of maximizing data transfer to the country's data processing centre (DPC) while respecting resource constraints. Benders' decomposition-based algorithm (BDA) is proposed to solve the NP-hardness of the problem and is shown to perform well in producing near-optimal solutions. The effectiveness and efficiency of the proposed strategy is verified through simulation results performed in a realistic environment, showing high speed and performance comparable to search methods. By informing the design and optimization of future communication systems, this study will provide a better understanding of how HAP and LEO satellites work together in aerial access networks for the collection and delivery of remote terrain data. 2024 IEEE. -
Investigation on Constraints and Recommended Context Aware Elicitation for IoT Runtime Workflow
Various technological and application challenges arise in the advancement of Internet of Things. Apart from Design and Deployment, Security also falls as a primary challenge to overcome. Device Management is becoming more complex as numerous network services to be handled. Inter-device communication for technical aspects appears to be underappreciated. There is a critical necessity to include this area's requirements and challenges. By abstracting data models and operations and expressing them using semantics, M2Mcommunication and interoperability and may be made simple. A thorough investigation of the foregoing is preparing the way for various approaches. Along with Semantics, a high-level language construct is suggested that can enable run-time workflow construction. Things Markup Language is the name of the concept (TML). 2024, Ismail Saritas. All rights reserved. -
A study on impact of celebrity endorsement on customer attitude towards the brand and purchase intention
Today celebrity endorsement has become a trend and been used as a winning formula and celebrities in India are the role models; people in the country are so influenced that they are attracted & follow the trends, styles also, consume the product they endorse and they associate the brand with the celebrity therefore the companies and the marketers believe that celebrity changes the purchase intention of the buyer. So this has been conducted to find out the impact of celebrity endorsement on customer attitude towards the brand and intention to purchase. To achieve the objective a questionnaire has been formed to collect the primary data of minimum of 200 respondents that will help to come to a conclusion about the impact if celebrity endorsement. The study also tries out to find out the various factors that affect a buyer purchase intention. For this study attributes of a celebrity and the brand have been studied also the attitude towards the brand. To acquire the required results the questionnaire was distributed to the target group aged 15-50 and the data collected was studied , analyzed to come to the conclusion whether celebrity influence the target group of consumers. -
Political propaganda portrayed in Hindi films /
Politics being one of the central object in democratic and highly politicize country like India has its impact and influence on every walk of life of this country. Since the beginning of the 20th century cinema in many ways has influenced social consciousness and helped in shaping our inner understanding. Both cinema & politics become important aspects of our society. It is important to study how they interact and how cinema adopt or take shape via political discourse of this country. -
Perspectives Envisaging Employee Loyalty : A Case Analysis
Journal of Management Research Vol. 12, No. 2, pp 100-112, ISSN No. 0974-455X -
Understanding motion poster as an emerging trend in Telugu film promotion /
Telugu film industry is one of the biggest industry in the world with its largest number of film production annually. It produces more than 300 films per year. Telugu film industry has adopted a brand new technology from Hollywood which is gaining popularity in the current promotional techniques. This new trend is called as first look Motion Poster. Motion posters are different from normal wall posters. -
Influence of emotional intelligence as mediator between workplace spirituality and organisational citizenship behaviour
Spirituality at work has developed as a research discipline over the last decade. There have been a few theoretical studies emphasizing on the significance of the construct. The external and internal factors affecting the relationship of this construct need to be analysed for enabling its implementation in the business world. The construct needs further empirical studies to establish itself as an implementable HR practice, contributing significantly to the bottom line. Organisational citizenship behaviour is critical for performance amidst uncertainty. Emotional intelligence has become more critical in overcoming the challenges faced by the Information Technology (IT) sector in India. This study fills the gap in the current literature studying the influence of emotional intelligence in the relationship between workplace spirituality and organisational citizenship behaviour in the Indian IT sector context. The challenges faced by the Indian IT sector are unique and needs alternative solution to avoid a downfall in the sector contributing majorly to the national GDP. The sample is 800 IT sector employees selected through judgmental sampling. The data is collected by using online survey instruments. SEM modelling has been used to analyse the data and use the same for development of an implementable model relating the dependent and the independent variables. -
Device, system and method for wireless control of medical devices /
Patent Number: 202121038822, Applicant: Dr K. Sampath Kumar.
The various embodiments of the present invention provide a device coupled with a medical apparatus for controlling a function of the said medical apparatus. The device comprises a processing unit, a communication coupler, an actuator, an accelerometer and a sensor package. The communication coupler provides a communication interface between the processing unit and a processor of a medical apparatus. The actuator is connected to the processing unit through an electromechanical mechanism. The accelerometer is connected to the processing unit through a bidirectional channel to control axial stability in a desirable position. The sensor package is installed over the medical apparatus and is connected to the processing unit.