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Anti-vibrio effects of the precious Tibetan pill, Rinchen Drangjor Rilnag Chenmo (RDRC)
Tibetan precious pills are an integral part of TTM (Traditional Tibetan Medicine). Among them, Rinchen Drangjor Rilnag Chenmo (RDRC) has been named King of Precious Pills due to its efficacy in treating a multitude of human disorders. RDRC has a complex formulation with about 140 ingredients, mostly from medicinal plants and a few precious stones and metals. Not many studies have been done on the experimental validation of antimicrobial properties of this important pill. The current study investigated the antimicrobial activity of the extracts of RDRC. Both aqueous and chloroform extracts were evaluated for their antibacterial potential against a total of seven different bacterial species, which are pathogenic, including three species of Vibrio, viz. V. vulnificus, V. parahaemolyticus and V. harveyi using the well-diffusion method and also by assessing MIC and MBC values. Its antifungal potential was also studied against two fungal strains Aspergillus Niger and Talaromyces islandicus. It was found that the chloroform extract of RDRC exerted a positive antibacterial effect on all the Vibrio species tested, and the least MIC of 3.33 mg/ml was observed for V. parahaemolyticus. This is the first study of its kind on the anti-Vibrio effect of the Tibetan precious pill, Rinchen Drangjor Rilnag Chenmo. Dhargyal et al (2021). This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited (https://creativecommons.org/licenses/by/4.0/). -
Efficient lipophilicity prediction of molecules employing deep-learning models
Lipophilicity, expressed as logP, is a significant physiochemical property and is an indicator of absorption, distribution, metabolism and elimination characteristics of drugs used in medication. It is one of the major deciding factors of the fate of a molecule to be a successful drug. Mol2vec is a convenient and unsupervised machine learning technique which produces high-dimensional vector representations of molecules and its molecular substructures. The work described here aims to simplify prediction of logP values with high-degree of accuracy by using Deep Learning (DL) models paired with Mol2vec. The work described in this paper empirically demonstrates that by using the described DL models paired with Mol2vec, one can achieve results which are much better than the conventional ML techniques as well as more complex and recent algorithms like Message-passing Neural Networks (MPNN), Graph Convolution (GC) and Spatial Graph embedding (C-SGEN). Our RMSE (Root Mean Square Error) scores from the ensemble model is one of the best reported so far in literature. The methods elaborated in this paper are simple, yet effective in predicting logP values to a great degree of accuracy due to the use of Mol2vec and standard TensorFlow operators. The models employed here can be coded and maintained with much more ease compared to the techniques of MPNN, C-SGEN or GC. 2021 Elsevier B.V. -
Multi-objective ANT lion optimization algorithm based mutant test case selection for regression testing
The regression testing is principally carried out on modified parts of the programs. The quality of programs is the only concern of regression testing in the case of produced software. Main challenges to select mutant test cases are related to the affected classes. In software regression testing, the identification of optimal mutant test case is another challenge. In this research work, an evolutionary approach multi objective ant-lion optimization (MOALO) is proposed to identify optimal mutant test cases. The selection of mutant test cases is processed as multi objective enhancement problem and these will solve through MOALO algorithm. Optimal identification of mutant test cases is carried out by using the above algorithm which also enhances the regression testing efficiency. The proposed MOALO methods are implemented and tested using the Mat Lab software platform. On considering the populace size of 100, at that point the fitness estimation of the proposed framework, NSGA, MPSO, and GA are 3, 2.4, 1, and 0.3 respectively. The benefits and efficiencies of proposed methods are compared with random testing and existing works utilizing NSGA-II, MPSO, genetic algorithms in considerations of test effort, mutation score, fitness value, and time of execution. It is found that the execution times of MOALO, NSGA, MPSO, and GA are 2.8, 5, 6.5, and 7.8 respectively. Finally, it is observed that MOALO has higher fitness estimation with least execution time which indicates that MOALO methods provide better results in regression testing. 2021 Scientific Publishers. All rights reserved. -
The Role of Board Independence and Ownership Structure in Improving the Efficacy of Corporate Financial Distress Prediction Model: Evidence from India
The study aimed to investigate the role of non-financial measures in predicting corporate financial distress in the Indian industrial sector. The proportion of independent directors on the board and the proportion of the promoters share in the ownership structure of the business were the non-financial measures that were analysed, along with ten financial measures. For this, sample data consisted of 82 companies that had filed for bankruptcy under the Insolvency and Bankruptcy Code (IBC). An equal number of matching financially sound companies also constituted the sample. Therefore, the total sample size was 164 companies. Data for five years immediately preceding the bankruptcy filing was collected for the sample companies. The data of 120 companies evenly drawn from the two groups of companies were used for developing the model and the remaining data were used for validating the developed model. Two binary logistic regression models were developed, M1 and M2, where M1 was formulated with both financial and non-financial variables, and M2 only had financial variables as predictors. The diagnostic ability of the model was tested with the aid of the receiver operating curve (ROC), area under the curve (AUC), sensitivity, specificity and annual accuracy. The results of the study show that inclusion of the two non-financial variables improved the efficacy of the financial distress prediction model. This study made a unique attempt to provide empirical evidence on the role played by non-financial variables in improving the efficiency of corporate distress prediction models. 2021 by the authors. -
Spectral quasi-linearization and irreversibility analysis of magnetized cross fluid flow through a microchannel with two different heat sources and Newton boundary conditions
Fluid flow in a microchannel with heat transport effects can be seen in various applications such as micro heat collectors, mechanicalelectromechanical systems, electronic device cooling, micro-air vehicles, and micro-heat exchanger systems. However, little is known about the consequence of internal heat source modulations on the flow of fluids in a microchannel. Therefore, in this work, the heat transfer of a magnetized cross fluid is carried out in a micro-channel subjected to two different heat source modulations. Entropy production analysis is also performed. The mathematical model consists of a cross fluid model. In addition, the effects of Joule heating, external magnetism, and the boundary conditions of Newton's heating are also examined. Determinant equations are constructed under steady-state conditions and parameterized using dimensionless variables. The numerical spectral quasi-linearization (SQLM) method was developed to interpret the Bejan number, entropy production, temperature, and velocity profiles. It is established that the power-law index of the cross fluid reduces the magnitude of the entropy production, velocity, and thermal field in the entire microchannel region. Furthermore, a larger Weissenberg number is capable of producing greater entropy, velocity, and thermal fields throughout the microchannel region. The variation in temperature distribution is more noticeable for the ESHS aspect than the THS aspect. The values of the pressure gradient parameter and the Eckert number must be kept high for maximum heat transport of the cross fluid. The entropy production of the cross fluid increases significantly with the physical aspects of Joule heating and convection heating in the system. 2021, The Author(s), under exclusive licence to SocietItaliana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature. -
Individual effects of sinusoidal and non-sinusoidal gravity modulation on Rayleigh-Bard convection in a ferromagnetic liquid and in a nanoliquid with couple stress
The effects of sinusoidal (sine wave) and non-sinusoidal (square wave, triangular wave, and sawtooth wave) forms of gravity modulation on Rayleigh-Bard Convection (RBC) in a ferromagnetic liquid and a nanoliquid with couple stress is examined using linear and non-linear stability analyses. From the linear analysis, the stability of the system is investigated by calculating the correction Rayleigh number using the Venezian method. The heat transfer coefficient is obtained by solving the non-autonomous Lorenz equation. The influence of various non-dimensional parameters on the onset of convection and heat transfer is analyzed. It is observed that the couple stress parameter stabilizes the system and decreases the heat transfer. It is found that the square type of gravity modulation facilitates more heat transport compared to other types of gravity modulation. The ferromagnetic parameters are shown to have their known influence on the onset of convection and heat transport. The results of the single-phase ferromagnetic nanoliquid with couple stress are extracted from the results of the ferromagnetic liquid with couple stress. Advancement of onset due to nanoparticle presence and thereby enhanced heat transfer is discussed. The higher concentration of alumina is shown to be preferable to the rather expensive copper nanoparticles in obtaining the same quantity of heat transfer. 2021, The Author(s), under exclusive licence to EDP Sciences, SocietItaliana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature. -
Electron beam mediated synthesis of photoluminescent organosilicon nanoparticles in TX-100 micellar medium and their prospective applications
The inherent advantages of Silicon have made it as one of the most sought-after elements in the field of nanoscience and nanotechnology. Herein, we report an electron-beam induced formation of blue light emitting organosilicon nanoparticles (OSiNPs) in the micellar medium of Triton X-100 (TX-100). The profound role of the micellar medium can be realized from the enhanced colloidal stability as well as photoluminescence (PL) quantum efficiency (from ~9% to ~55%) of as synthesized OSiNPs. Mechanistic investigations revealed the crucial role of hydroxyl radical ([rad]OH) in the formation of OSiNPs. XPS and FTIR studies indicated the presence of siloxane/silicone and silica (SiO2) like units as the major constituents in the NPs. XRD pattern showed the amorphous nature of the NPs, while TEM studies revealed their aggregation. The hydrodynamic size of the NPs was determined to be ~24 nm. Interestingly, the NPs exhibited an excitation-wavelength-dependent PL behaviour, thereby indicating the presence of multiple emission centres (ECs). Detailed investigations based on steady-state as well as time-resolved PL measurements were conducted to analyse these ECs. In addition, pH and temperature-dependent studies were carried out to further substantiate these findings. Moreover, the experimental observations revealed their potential applications in the areas of thermosensing, fingerprinting and cell-imaging. Notably, the internalization of as prepared NPs within cells was evident from the bright fluorescence images obtained from the cytoplasmic region as compared to control cells. This observation also suggests the prospective application of these NPs for image guided drug delivery systems. 2021 Elsevier B.V. -
Dynamic optimal network reconfiguration under photovoltaic generation and electric vehicle fleet load variability using self-adaptive butterfly optimization algorithm
Currently, electrical distribution networks (EDNs) have used modern technologies to operate and serve many types of consumers such as renewable energy, energy storage systems, electric vehicles, and demand response programs. Due to the variability and unpredictability of these technologies, all these technologies have brought various challenges to the operation and control of EDNs. In this case, in order to operate effectively, it is inevitable that effective power redistribution is required in the entire network. In this paper, a multi-objective based dynamic optimal network reconfiguration (DONR) problem is formulated using power loss and voltage deviation index considering the hourly variation of load, photovoltaic (PV) power, and electric vehicle (EV) fleet load in the network. This paper introduces recently introduced meta-heuristic butterfly optimization algorithm (BOA) and it's improve variant of self-adaptive method (SABOA) for solving the DONR problem. The simulation study of IEEE 33-bus EDN under different conditions has proved the effectiveness of DONR, and its adoptability for real-time applications. In addition, by comparing different performance indicators (such as mean, standard deviation, variance, and average calculation time) of 50 independently run simulations, the efficiency of SABOA can be evaluated compared with other heuristic methods (HMs). Comparative studies show that SABOA is better than PSO, TLBO, CSA and FPA in the frequent occurrence of global optimal values. 2021 Walter de Gruyter GmbH, Berlin/Boston 2021. -
Studies on Parametric Optimization of HVOF-Sprayed Cr2O3 Coatings on Al6061 Alloy
High-velocity oxy-fuel (HVOF) is a widely used thermal spray technique to obtain high density, high bond strength, and improved hardness coatings. In the present work, optimization of HVOF process parameters was carried out using the Taguchi method to minimize porosity and improve microhardness, and bond strength of Cr2O3 coatings. Based on the signal-to-noise ratio and analysis of variance, the significance of each process parameter and optimum parameter combination is obtained. Based on the signal-to-noise ratio, the most significant process parameter affecting porosity and microhardness was standoff distance, while for bond strength, it was powder feed rate. An optimal combination of process parameters for porosity, microhardness, and bond strength was obtained from S/N ratio analysis. For porosity, optimal parameters were standoff distance of 100rpm, powder feed rate of 30g/min, and gun speed of 250mm/s. The optimal process parameters for microhardness were standoff distance of 300rpm, powder feed rate of 50g/min, and gun speed of 200mm/s. Finally, for bond strength, the optimal process parameters were standoff distance of 300rpm, powder feed rate of 50g/min, and gun speed of 250mm/s. Statistical results for porosity, microhardness, and bond strength showed that the difference between the predicted R2 and adjusted R2 values were relatively minimal and close to the one highlighting the fitness of the regression model employed for analysis. Fracture analysis after bond strength test showed combined adhesion/cohesion type failure for the Cr2O3 coatings. 2021, The Indian Institute of Metals - IIM. -
Heat transport of hybrid nanomaterial in an annulus with quadratic Boussinesq approximation
The convective heat transfer of hybrid nanoliquids within a concentric annulus has wide engineering applications such as chemical industries, solar collectors, gas turbines, heat exchangers, nuclear reactors, and electronic component cooling due to their high heat transport rate. Hence, in this study, the characteristics of the heat transport mechanism in an annulus filled with the Ag-MgO/H2O hybrid nanoliquid under the influence of quadratic thermal radiation and quadratic convection are analyzed. The non-uniform heat source/sink and induced magnetic field mechanisms are used to govern the basic equations concerning the transport of the composite nanoliquid. The dependency of the Nusselt number on the effective parameters (thermal radiation, nonlinear convection, and temperature-dependent heat source/sink parameter) is examined through sensitivity analyses based on the response surface methodology (RSM) and the face-centered central composite design (CCD). The heat transport of the composite nanoliquid for the space-related heat source/sink is observed to be higher than that for the temperature-related heat source/sink. The mechanisms of quadratic convection and quadratic thermal radiation are favorable for the momentum of the nanoliquid. The heat transport rate is more sensitive towards quadratic thermal radiation. 2021, Shanghai University and Springer-Verlag GmbH Germany, part of Springer Nature. -
Significance of inclined magnetic field on nano-bioconvection with nonlinear thermal radiation and exponential space based heat source: a sensitivity analysis
The characteristics of heat transport in nanoliquids under the influence of bio-convection (motile microorganism) have significant applications, since nanoliquids have greater capacity to improve heat transport properties than conventional liquids. With these incredible nanoliquid characteristics, the main objective of current research is to examine the impact of the exponential heat source linked to space and the inclined magnetic force on the nano-bioconvective flow between two turntables. The effect of nonlinear thermal radiation, variable thermal conductivity and viscosity aspects are also considered. The complicated nonlinear problem is treated numerically by using Finite difference method. Optimization procedure implemented via Response surface Methodology for the effective parameters thermophoresis parameter, Hartmann number and radiation parameter on the heat transfer rate. The axial velocity is a dwelling function of the inclined angle of the magnetic field, and the variable viscosity parameter. The temperature profile hikes with an exponential space-related heat source and thermal radiation aspects. Also, the heat transport rate is highly sensitive towards nonlinear thermal radiation parameter compared to the thermophoresis effect and Hartmann number. 2021, The Author(s), under exclusive licence to EDP Sciences, SocietItaliana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature. -
Influence of hydrothermal synthesis conditions on lattice defects in cerium oxide
Cerium oxide makes one of the most promising materials for chemical transformations in environmental and energy applications. Herein, the influence of hydrothermal conditions on the physico-chemical characteristics of cerium oxide prepared from salt solution via ammonia precipitation is analyzed. The systems are well characterized using SEM, TEM, XRD analysis, photoluminescence spectra, Raman spectra, TPR study. and XPS analysis. Normal aqueous conditions lead to particles of size ~8 ?nm, with truncated octahedral geometry, closer to spheroid shape (RT-Ce) bound by {111} and {100} planes. Elevated temperature facilitated preferential exposed {100} plane bounded cubic ceria structures of size ~15 ?nm (HT-Ce), which are stabilized by more number of anion vacancies. Low temperature synthesis yielded smaller sized particles with less crystallinity and higher surface area, when compared to hydrothermal route. Lattice defects, represented in terms of Ce3+ ions and associated lattice oxygen vacancies are seen in higher amounts in ceria synthesised via hydrothermal path, as supported by various characterization results. CeO2 achieved via hydrothermal path exhibited higher catalytic oxidation activity, which is examined using a model oxidation reaction, vis., CO oxidation. The enhanced activity of HT-Ce is explained through the defect structure induced facile redox shift in the system. 2021 Elsevier Inc. -
Effects of Variable Viscosity and Internal Heat Generation on RayleighBard Convection in Newtonian Dielectric Liquid
The onset of RayleighBard convection of variable-viscosity Newtonian dielectric liquid confined between two parallel plates is subject to free-free isothermal boundary condition. The combined and individual effects of temperature-dependent and electric-field-dependent variable-viscosity along with the internal heat generation are studied using the higher order Galerkin technique. This theoretical study shows that even a mild temperature-dependent variable-viscosity destabilizes the system and the electric-field-dependent variable-viscosity stabilizes the system both in the absence/presence of heat source/sink. 2021, The Author(s), under exclusive licence to Springer Nature India Private Limited. -
Molecularly Imprinted Scaffold Based on poly (3-aminobenzoic acid) for Electrochemical Sensing of Vitamin B6
Inadequate or excess consumption of Vitamin B6 (Vit B6) can have ill effects on the overall well-being of humans, thereby making it necessary to control their content and composition in the food we consume. A simple sensor is fabricated in this work for Vit B6 detection based on employing an electropolymerized molecularly imprinted polymer (MIP) of 3-amino benzoic acid. The poly (3- aminobenzoic acid) (P-(3ABA)) film was electrodeposited by potentiodynamic cycling of potential with and without Vit B6 (template) on carbon fiber paper electrode (CFP). The modified working electrodes were characterized by electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). Field emission scanning microscopy, Energy dispersive X-ray spectrometry, Fourier Transform Infrared spectroscopy, Optical profilometry and X-ray photon electron spectroscopy were used for characterization. Nyquist plots revealed least charge transfer resistance at MIP/CFP than other control electrodes due to the molecularly imprinted sites. Under the optimized experimental conditions the developed MIP sensor showed a linear range 0.6 ?M to 700 ?M, with a detection limit of 0.010 ?M. Also a value of the imprinting factor (? = 3.50) indicates very good selectivity of the prepared sensor towards Vit B6 detection over its structurally similar analogues in the analysis of real sample matrices. 2021 The Electrochemical Society ("ECS"). Published on behalf of ECS by IOP Publishing Limited. -
Transition metal oxides in electrochemical and bio sensing: A state-of-art review
This review article portrays the progress in developing novel electrochemical sensors using morphologically varied transition metal oxides. The role and applications of transition metal oxide nanoparticles of iron, titanium, manganese, zirconium, cobalt, nickel and their composites in the field of electrochemical and bio sensing are conferred in detail. Appropriate chemical functionalization of these nanomaterials guarantees the selective and sensitive determination of target molecules including DNA or creating antigen/antibody complexes. Substantial data is summed up in the tables. This review article highlights the significance of transition metal oxide nanoparticles as promising electrode modifiers for fabrication of sensors. The review ends up with a relevant discussion, existing challenges and future scopes. 2021 The Author(s) -
Tamarindusindica Mediated Combustion Synthesis of BiOCl: Photocatalytic Degradation of Dyes and Synthesis of ?-Enaminones
Environmental pollution due to dyes has been increasing continuously due to the large number of textile industries, which affects living systems. Photocatalytic degradation (PCD) is one of the most efficient methods to expel organic dyes in wastewater. In this respect, synthesizing photocatalytic nanoparticles to degrade organic dyes by a simple and cost-effective method is the real challenge. In this article, a carcinogenic dye, methylene blue, is considered for our study as it releases highly toxic species into the ecosystem and causes severe health problems such as cancer, skin and kidney problems, etc. Bismuth oxychloride has been synthesized by simple, low cost and rapid combustion method using low cost, easily available Tamarindusindica as a fuel at 500 C for ~10 min. The obtained BiOCl has been characterized by x-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy, scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HR-TEM), UV-Vis spectroscopy, photoluminescence spectroscopy and surface area by BrunauerEmmettTeller (BET). The XRD pattern shows a tetragonal phase and the FT-IR spectrum shows the presence of Bi-Cl at 1109 cm?1. SEM shows a flake-like morphology and HR-TEM displays d-spacing values of 0.13 nm. Photoluminescence studies show a green emission peak at 530 nm. Synthesis of ?-enaminones was also examined using analogues of aniline and dimedone in presence of BiOCl as a photocatalyst. 2021, The Minerals, Metals & Materials Society. -
An analysis of the ethical challenges of blockchain-enabled E-healthcare applications in 6G networks
Developments in blockchain technology coupled with rapid developments in network technologies have disrupted traditional business and service models. One such application is in the domain of healthcare. However, the domain's sensitive nature and complexity require blockchain-enabled e-healthcare to ensure utilitarianism while suitably addressing the associated ethical challenges. In this milieu, the paper attempts to identify and evaluate the parameters of ethical challenges associated with blockchain adoption in e-healthcare. This paper contributes to the extant body of knowledge by presenting a critical review of the ethical considerations at the meso level of blockchains in e-healthcare. Based on findings from the literature, the study identified nine parameters of blockchain ethics. Of these, Accuracy and Right to be Forgotten were found to be most critical in terms of ethical dilemmas in healthcare applications. No evidence of ethical dilemma could be found with respect to Accountability and Data Ownership. As these services are deployed over networks, all these challenges are further evaluated in the context of 6G network-based models. This will not only provide the stakeholders with a holistic view of the ethical challenges in various blockchain-enabled healthcare applications but also enable a meticulous transition to the 6G network. 2021 -
Multilayer flow and heat transport of nanoliquids with nonlinear Boussinesq approximation and viscous heating using differential transform method
Multilayer fluid flow models are significant in various applications, namely, cooling electronic systems, solar thermal systems, and nuclear reactors. The density of a fluid fluctuates nonlinearly due to large temperature difference circumstances in thermal systems. Thus, the linear Boussinesq approximation is no longer relevant. Therefore, this article describes a multilayer flow of nanoliquids in the presence of nonlinear Boussinesq approximation. The hybrid nanoliquid layer is sandwiched between two nanoliquid layers. The single-phase khanafer-vafai-lightstone model is implemented to simulate the nanoliquids. The quadratic density temperature fluctuation and viscous heating are taken into account. The temperature and velocity across the interface are assumed to be continuous. The equations that govern the problem are solved analytically by using the differential transformation method. The results show that the presence of a hybrid nanoliquid layer affects the velocity and heat transfer properties of the nanofluid flow. Hybrid nanofluid can be used to achieve the desired multilayer flow properties of a nanofluid and its heat transfer properties. Further, the quadratic convection aspect increases the velocity distributions. 2021 Wiley Periodicals LLC -
Effect of Non-inertial Acceleration on BrinkmanBard Convection in Water-Copper Nanoliquid-Saturated Porous Enclosures
In the present paper we have considered rotating porous tall, square and shallow enclosures heated from below. Linear and non-linear analyses are made using a minimal representation by Fourier trigonometric series. The study is done for realistic boundary condition. Thermophysical properties of water-copper nanoliquid as a function of properties of water as base liquid, copper as nanoparticle and 30% glass fiber reinforced polycarbonate as porous medium are obtained from either phenomenological laws or mixture theory. Non-existence of oscillatory convection is discussed. The range for the existence of unicellular convection is mentioned. The effects of Brinkman number (?), porous parameter (?2), aspect ratio (A) and volume fraction (?) in the presence of rotation on the onset of convection and heat transfer are studied and illustrated graphically. The analytically intractable Lorenz model is derived and transformed into the tractable GinzburgLandau equation using the multiscales method. The definition of Ozoe heat transfer parameter is introduced to discuss the rate of heat transfer enhancement or reduction. It is observed that Ta, ? and ?2 have stabilizing effect on the system and thereby leading to diminished heat transfer whereas A and ? have destabilizing effect on the system and thereby leading to increased heat transfer. Among the three enclosures considered in the study enhanced heat transfer takes place in tall enclosure followed by square and shallow enclosures respectively. It is further observed that presence of nanoparticles advances the onset of convection and enhances the heat transfer. The results of the paper are compared with previous existing results in the absence of rotation and the good agreement is found between them. 2021, The Author(s), under exclusive licence to Springer Nature India Private Limited. -
The COVID-19 vaccine preference for youngsters using promethee-ii in the ifss environment
Extensive decision-making during the vaccine preparation period is unpredictable. An account of the severity of the disease, the younger people with COVID-19 comorbidities and other chronic diseases are also at a higher risk of the COVID-19 pandemic. In this research article, the preference ranking structure for the COVID-19 vaccine is recommended for young people who have been exposed to the effects of certain chronic diseases. Multiple Criteria Decision-Making (MCDM) approach effectively handles this vague information. Furthermore, with the support of the Intuitionistic Fuzzy Soft Set (IFSS), the entries under the new extension of the Preference Ranking Organization Method for Enrichment Evaluation-II (PROMETHEE-II) is suggested for Preference Ranking Structure. The concept of intuitionistic fuzzy soft sets is parametric in nature. IFSS suggests how to exploit an intuitionistic ambiguous input from a decision-maker to make up for any shortcomings in the information provided by the decider. The weight of the inputs is calculated under the Intuitionistic Fuzzy Weighted Average (IFWA) operator, the Simply Weighted Intuitionistic Fuzzy Average (SWIFA) operator, and the Simply Intuitionistic Fuzzy Average (SIFA) operator. An Extended PROMETHEE-based ranking, outranking approach is used, and the resultant are recommended under the lexicographic order. Its sustainability and feasibility are explored for three distinct priority structures and the possibilities of the approach. To demonstrate the all-encompassing intuitionistic fuzzy PROMETHEE approach, a practical application regarding COVID-19 severity in patients is given, and then it is compared to other existing approaches to further explain its feasibility, and the sensitivity of the preference structure is examined according to the criteria. 2021 by the authors. Licensee MDPI, Basel, Switzerland.