Synthesis of Benzothiazinones Benzothiazines and Their Selenium Analogues Through Novel Synthetic Routes
- Title
- Synthesis of Benzothiazinones Benzothiazines and Their Selenium Analogues Through Novel Synthetic Routes
- Creator
- Putta, V P Rama Kishore.
- Contributor
- Pujar, Prasad Pralhad
- Description
- Benzo fused N-heterocyclic scaffolds containing oxygen, sulphur or selenium have found wide interest in the field of drug-discovery. Among these N-heterocycles, benzothiazine, benzoxazine, benzoselenazine and benzothiazinone derivatives are a unique class of compounds and have a larger scope towards the development of efficient and simple synthetic methodologies for their synthesis with readily available substrates. newlineDuring the course of the present thesis a convenient and simple synthetic procedures were developed for the synthesis of benzothiazines, benzoxazines, benzoselenazines and benzothiazinones in an onepot methodology. 2-aryl/alkyl substituted 1,3-benzothiazines and selenazines were synthesized by reacting 2-amino benzyl alcohols and thio or seleno benzamides in the presence of T3P.A reagent controlled methodology was developed for the synthesis of 2-amino substituted 1,3-benzothiazines and oxazines. Initially, various 2-amino benzylalcohols are reacted with newlineisothiocyanates to form the corresponding thioureas. The formed thioureas undergo newlinecyclodehydration in the presence of T3P to yield 2-amino substituted 1,3-benzothiazines newlineand on the other hand molecular iodine facilitates desulfurization of the thiourea to yield 2-amino substituted 1,3-benzoxazines. 2-amino substituted 1,3-benzothiazinones were synthesized by reacting anthranilic acids and isothiocyanates in the presence of EDC.HCl. 2-aryl substituted 1,3-benzothiazinones were synthesized by employing thiobenzamides in the presence of T3P. All the compounds synthesized were characterized by 1HNMR, 13C, Mass spectroscopic (LCMS, HRMS) analysis. Docking studies against TANKYRASE-1 enzyme for colorectal cancer (CRC) and antibacterial studies were also discussed.
- Source
- Author's Submission
- Date
- 2020-01-01
- Publisher
- Christ(Deemed to be University)
- Subject
- Chemistry
- Rights
- Open Access
- Relation
- 61000154
- Format
- Language
- English
- Type
- PhD
- Identifier
- http://hdl.handle.net/10603/344779
Collection
Citation
Putta, V P Rama Kishore., “Synthesis of Benzothiazinones Benzothiazines and Their Selenium Analogues Through Novel Synthetic Routes,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 23, 2025, https://archives.christuniversity.in/items/show/12125.