Multi-component condesation mediated synthesis of bioactive heterocyclic compounds

Title

Multi-component condesation mediated synthesis of bioactive heterocyclic compounds

Creator

Mishra, Manisha

Contributor

Nizam, Aatika

Description

Aromatic heterocycles constitute the most diverse family of organic compounds. Moreover, aromatic heterocycles are widely used for the synthesis of dyes and polymeric materials of high value. The development of selective reactions that utilize easily available and abundant precursors for the efficient synthesis of heterocyclic compounds is a long-standing goal of chemical research. Despite the centrality of its role in a number of important research areas, including medicinal chemistry, total synthesis, and materials science, a general, selective, step-economical, and step-efficient synthesis of heterocycles is still needed. newlinePyrano[2,3-c]pyrazole derivatives have been synthesised by a one-pot multicomponent condensation of different aldehydes, dialdehydes, and ketones with malononitrile, ethyl acetoacetate, hydrazine hydrate (or phenylhydrazine) in the presence of magnetic nano-[CoFe2O4] catalyst under ultrasonic irradiation. The catalyst can be retrieved using an external magnet and used repeatedly. A practical, scalable method for obtaining various pyranopyrazoles has been demonstrated. The extraordinary catalytic role of the various catalyst has been discovered in the processes, which reveals a possible character of enhancing reaction rates and stabilising the intermediates during the course of the reactions.

Source

Author's Submission

Date

2021-01-01

Publisher

Christ(Deemed to be University)

Subject

Chemistry

Rights

Open Access

Relation

61000185

Format

PDF

Language

English

Type

PhD

Identifier

http://hdl.handle.net/10603/393394