Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource PHD PhD PhD Thesis Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Relation A related resource 61000278 Title A name given to the resource Synthesis of Thiazines, Thiazinones and N-Cycloalkyl Azoles Via Novel Synthetic Routes Subject The topic of the resource Chemistry Description An account of the resource Heterocyclic building blocks have gained the utmost importance in recent past on the newlineaccount of their significance in biological and pharmaceutical fields. Among these newlinenitrogen and sulphur containing heterocyclic building blocks such as thiazines, newlinethiazinones and N-cycloalkyl heterocyclic motifs hold an important role in medicinal newlinechemistry. Thiazine cores are used for the treatment of various life threating diseases newlinelike cancer, cardiovascular and fabry diseases. Drugs containing thiazinone cores were used to treat Parkinson, Alzheimer s and various neuro degenerative diseases. Ncycloalkyl azole motifs are used to treat various life threating cancers like neck, lung, prostate, breast etc. As per the literature review, synthesis of these motifs are done using multi steps and harsh conditions, which limited the substrate scope. In this thesis we describe our studies on development of one pot, mild condition for newlinesynthesis of thiazinone cores using P(NMe2)3 (HMPT). We had developed HMPT [P(NMe2)3] mediated reactions towards synthesis of Carbon-Nitrogen/Carbon-Sulphur bond. The developed methodology was extended for thiazine cores as well. This new synthetic methodology is useful to synthesize various N, S-heterocycles including the novel spiro molecules. HMPT reagent under the mild and aerobic reaction conditions provided the access for many manifold immense molecules. Molecular docking studies were conducted for the synthesized compounds considering MOA-B inhibitors as target. MOA-B inhibitor motifs were approved for the treatment of Parkinson illness. The synthesized thiazine and thiazinone molecules showed good binding affinity in molecular docking studies conducted. We had developed a new strategy using T3P (1-Propanephosphonic anhydride, ~ 50 % wt, in EA solution) mediated synthetic procedure for the synthesis of N-cycloalkyl newlineazoles. Creator An entity primarily responsible for making the resource Polina, Sai Babu Source A related resource from which the described resource is derived Author's Submission Publisher An entity responsible for making the resource available Christ(Deemed to be University) Date A point or period of time associated with an event in the lifecycle of the resource 2023-01-01 Contributor An entity responsible for making contributions to the resource Prasad, Pralhad Pujar Rights Information about rights held in and over the resource Open Access Format The file format, physical medium, or dimensions of the resource PDF Language A language of the resource English Type The nature or genre of the resource PhD Identifier An unambiguous reference to the resource within a given context <a href="http://hdl.handle.net/10603/533970" target="_blank" rel="noreferrer noopener">http://hdl.handle.net/10603/533970</a>