Biomarkers of Autistic Study : Biochemical, Genomics, Epigenetics and Cytogenetic Signatures
- Title
- Biomarkers of Autistic Study : Biochemical, Genomics, Epigenetics and Cytogenetic Signatures
- Creator
- M, Arun
- Contributor
- P, Manikantan
- Description
- Autism is a complex disorder characterized by social issues, impaired communication, newlineand repetitive behavior. The prevalence of autism has increased significantly over the past two decades, with an estimated incidence of 1 in 150 children in 2000. Cytogenetic investigations are essential for confirming clinical diagnoses, as the disorder has high phenotypic variability and genetic heterogeneity. A study aims to confirm behavioral phenotypes of autistic subjects newlinein South India using DSM IV and ATEC open questionnaires. The study found that metabolic factors, including hormones, neurotransmitters, and oxidative ions, play crucial roles in the progression of symptoms. The study also revealed the roles of two major causative genes (NRXN1 and CNTNAP2) in a spectrum of genotypes imparting severity and heterogeneity.
- Source
- Author's Submission
- Date
- 2024-01-01
- Publisher
- Christ(Deemed to be University)
- Subject
- Life Sciences
- Rights
- Open Access
- Relation
- 61000368
- Format
- Language
- English
- Type
- PhD
- Identifier
- http://hdl.handle.net/10603/585925
Collection
Citation
M, Arun, “Biomarkers of Autistic Study : Biochemical, Genomics, Epigenetics and Cytogenetic Signatures,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 23, 2025, https://archives.christuniversity.in/items/show/12414.