Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A First Report of Docosahexaenoic Acid-Clocked Polymer Enveloped Gold Nanoparticles: A Way to Precision Breast Cancer and Triple Negative Breast Cancer Therapy and Its Apoptosis Induction Subject The topic of the resource apoptosis; breast cancer; docosahexaenoic acid; drug delivery; gold nanoparticles Description An account of the resource Functionalized gold nanoparticles (GNPs) are extensively utilized in various disciplines due to their excellent bioactivity, biocompatibility, and extended drug half-life, influenced by the ligands and size that are changed on surfaces. In this study, we successfully fabricated GNPs coated with ligands containing docosahexaenoic acid (DHA) and polyethylene glycol (PEG) clocked by a carboxyl group. These nanoparticles are referred to as MPA@GNPs-PEG-DHA. The cytotoxicity results demonstrate that MPA@GNPs-PEG-DHA exhibits superior cell selectivity, explicitly inhibiting the proliferation of breast cancerous cells than noncancerous cell lines. Apoptosis is involved in the reduction of cell proliferation by MPA@GNPs-PEG-DHA, as demonstrated clearly through many assays measuring apoptotic index, including AO/EB staining, DAPI, annexin V-FITC staining, mitochondrial membrane potential (MMP), and reactive oxygen species (ROS) measurement. The efficacy of MPA@GNPs-PEG-DHA in inducing apoptosis was demonstrated by its inhibition of mitochondrial dysfunction by ROS. MPA@GNPs-PEG-DHA has the potential to improve the induction of apoptosis in breast cancerous cells. 2024 Wiley Periodicals LLC. Creator An entity primarily responsible for making the resource Khanna L.; Ballal S.; Awasthi K.K.; Singh D.; Chinnathambi A.; Alahmadi T.A.; Abudoleh S.M.; Thangavelu I. Source A related resource from which the described resource is derived Journal of Applied Polymer Science, Vol-142, No. 8 Publisher An entity responsible for making the resource available John Wiley and Sons Inc Date A point or period of time associated with an event in the lifecycle of the resource 2025-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1002/app.56505" target="_blank" rel="noreferrer noopener">https://doi.org/10.1002/app.56505</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85212793141&amp;doi=10.1002%2Fapp.56505&amp;partnerID=40&amp;md5=22c3ff11768cb4e982733cdd606f9ca8" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85212793141&amp;doi=10.1002%2fapp.56505&amp;partnerID=40&amp;md5=22c3ff11768cb4e982733cdd606f9ca8</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 218995; CODEN: JAPNA Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Khanna L., Chitkara Centre for Research and Development, Chitkara University, Himachal Pradesh, Pinjore, India; Ballal S., Department of Chemistry and Biochemistry, JAIN (Deemed-to-be University), Karnataka, Bangalore, India; Awasthi K.K., Department of Sciences, Vivekananda Global University, Jaipur, India; Singh D., Centre of Research Impact and Outcome, Chitkara University, Punjab, Rajpura, India; Chinnathambi A., Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia; Alahmadi T.A., Department of Pediatrics, College of Medicine and King Khalid University Hospital, King Saud University, Medical City, Riyadh, Saudi Arabia; Abudoleh S.M., Faculty of Pharmacy, Middle East University, Amman, Jordan; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bangalore, India