Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Construction of multifunctional hyaluronic acid modified gold nanoparticles clocked with Irinotecan and indocyanine green: Investigation of chemotherapy and cancer cell imaging Subject The topic of the resource Cancer; Gold nanoparticles; Hyaluronic acid; Imaging; Indocyanine green; Irinotecan Description An account of the resource To overcome the inherent limits of conventional cancer therapy, there is an immediate need to establish multifunctional drugs that combine accurate diagnosis with treatment. The work describes a small nanocomposite's mild and easy fabrication, including Irinotecan, folic acid, hyaluronic acid, and indocyanine green-integrated gold nanoparticles. The gold nanoparticles with indocyanine green integrated (HA@ICG/Au) were developed in one step for photodynamic treatment and biological fluorescence imaging. Both the drug delivery of Irinotecan and the enhancement of cellular selectivity are achieved by the hyaluronic acid-altered ICG/Au (HA@ICG/Au). To regulate the release of Irinotecan during tumour chemotherapy, the dual-targeted and pH-responsive system known as HA@ICG/Au:FA@IRI was developed. The nanocomposite composed of HA@ICG/Au:FA@IRI had a tiny surface area and was highly efficient at encapsulation and loading drugs. In an acidic milieu, the nanocomposite showed excellent biocompatibility, colloidal stability, photostability, and a rapid cumulative release rate. The improved cellular uptake of HA@ICG/Au:FA@IRI for fluorescence imaging was validated by fluorescence microscopy in vitro. The nanocomposite showed impressive cancer cell death when exposed to laser irradiation using a combination of synergistic chemotherapy and photodynamic treatment (PDT). Taken as a whole, the results show that the nanocomposite was successfully developed to target tumors in two different ways, resulting in a potentially helpful theranostics agent. 2025 Elsevier B.V. Creator An entity primarily responsible for making the resource Menon S.V.; Juneja B.; Joshi U.; Faujdar M.; Chinnathambi A.; Alahmadi T.A.; Arulselvan P.; Thangavelu I. Source A related resource from which the described resource is derived Journal of Drug Delivery Science and Technology, Vol-105 Publisher An entity responsible for making the resource available Editions de Sante Date A point or period of time associated with an event in the lifecycle of the resource 2025-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.jddst.2025.106629" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.jddst.2025.106629</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85216226454&amp;doi=10.1016%2Fj.jddst.2025.106629&amp;partnerID=40&amp;md5=b0b63c97fcb78030cb16a6e98b581f47" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85216226454&amp;doi=10.1016%2fj.jddst.2025.106629&amp;partnerID=40&amp;md5=b0b63c97fcb78030cb16a6e98b581f47</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 17732247; CODEN: JDDSA Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Menon S.V., Department of Chemistry and Biochemistry, JAIN (Deemed-to-be University), Karnataka, Bangalore, 560069, India; Juneja B., Centre of Research Impact and Outcome, Chitkara University, Punjab, Rajpura, 140417, India; Joshi U., Department of Mechanical Engineering, PIET, Parul University, Gujarat, Vadodara, 391760, India; Faujdar M., Department of Sciences, Vivekananda Global University, Jaipur, 391760, India; Chinnathambi A., Department of Botany and Microbiology, College of Science, King Saud University, PO Box -2455, Riyadh, 11451, Saudi Arabia; Alahmadi T.A., Department of Pediatrics, College of Medicine and King Khalid University Hospital, King Saud University, Medical City, PO Box-2925, Riyadh, 11461, Saudi Arabia; Arulselvan P., Department of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, 602105, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bangalore, 560029, India