Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Engineered biocorona on microplastics as a toxicity mitigation strategy in marine environment: Experiments with a marine crustacean Artemia salina Subject The topic of the resource Algae; Brine shrimp; Cell free extract; Engineered biocorona; Microplastics; Toxicity mitigation Description An account of the resource The marine environment has become a major sink for microplastics (MPs) wastes. When MPs interact with biological macromolecules, the biocorona forms on their surface, which can alter their biological reactivity and toxicity. In this study, we investigated the impact of biocorona formation on the toxicity of aminated (NH2) and carboxylated (COOH) polystyrene MPs towards the marine crustacean Artemia salina. Biocoronated MPs were prepared using cell-free extracts (CFEs) from microalgae Chlorella sp. (phytoplankton) and the brine shrimp Artemia salina (zooplankton). The results revealed that biocorona formation effectively reduced the toxicity of MPs. Pristine NH2-MPs exhibited higher reactive oxygen species production (ROS) (182%) compared to COOH-MPs (162%) in Artemia salina. Notably, NH2-MPs coronated with brine shrimp CFE exhibited a substantial reduction in ROS production (127%) than those coronated with algal CFE, with COOH-MPs showing a similar trend (120%). Biocorona formation also significantly decreased malondialdehyde (MDA) levels and antioxidant activity compared to pristine MPs. Molecular docking and dynamics simulations demonstrated a strong binding between polystyrene and acetylcholinesterase (AChE). In vitro studies indicated that pristine NH2-MPs exhibited more reduction in AChE activity (84%) compared to COOH-MPs (95%). However, no significant reduction in AChE activity was observed upon exposure to MPs coronated with either algal or brine shrimp cell-free extracts. Independent action modeling indicated an antagonistic interaction for MPs coronated with both the CFEs. Pearson correlation and cluster heatmap analysis suggested that the toxicity reduction in Artemia salina might be driven by decreased oxidative stress followed by the corona formation. Overall, this study provides valuable insights into the potential of biomolecules from phytoplankton and zooplankton to reduce MPs toxicity in Artemia salina, while highlighting their role in modulating the toxicity of other marine pollutants. 2024 The Author(s) Creator An entity primarily responsible for making the resource Rex M C.; Bairoliya A.; Gairola S.; Sureshkumar P.; Niranjan V.; Nag A.; Mukherjee A. Source A related resource from which the described resource is derived Journal of Hazardous Materials Advances, Vol-17 Publisher An entity responsible for making the resource available Elsevier B.V. Date A point or period of time associated with an event in the lifecycle of the resource 2025-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.hazadv.2024.100558" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.hazadv.2024.100558</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85211182987&amp;doi=10.1016%2Fj.hazadv.2024.100558&amp;partnerID=40&amp;md5=0b632afe476d72f031eb2aea40cf9f88" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85211182987&amp;doi=10.1016%2fj.hazadv.2024.100558&amp;partnerID=40&amp;md5=0b632afe476d72f031eb2aea40cf9f88</a> Rights Information about rights held in and over the resource All Open Access; Gold Open Access Relation A related resource ISSN: 27724166 Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Rex M C., Centre for Nanobiotechnology, VIT, Tamil Nadu, Vellore, 632014, India; Bairoliya A., Centre for Nanobiotechnology, VIT, Tamil Nadu, Vellore, 632014, India; Gairola S., Centre for Nanobiotechnology, VIT, Tamil Nadu, Vellore, 632014, India; Sureshkumar P., R V College of Engineering, Karnataka, Bengaluru, India; Niranjan V., R V College of Engineering, Karnataka, Bengaluru, India; Nag A., Department of Life Sciences, Christ University, Karnataka, Bengaluru, India; Mukherjee A., Centre for Nanobiotechnology, VIT, Tamil Nadu, Vellore, 632014, India