Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Facile fabrication of dasatinib laden multifunctional polymeric micelles: Evaluation of anti-proliferative and apoptotic activities in human cancer cells Subject The topic of the resource biomedical applications; conducting polymers; drug delivery systems Description An account of the resource Dasatinib (DAS) has recently gained significant interest for its anticancer potential. Yet, the lipophilicity inherent in DAS limited its potential use as a chemotherapeutic drug. This study aimed to examine the effectiveness of polyethylene glycol-polycaprolactone (PEG-PCL) as a nanocarrier for DAS to increase its anticancer capabilities. The DAS-loaded PEG-PCL nanoparticles (termed as DAS@PEG-PCL NPs) were characterized using Fourier transform infrared (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and dynamic light scattering (DLS). Morphological staining and MTT tests were employed to investigate drug-loaded nanoparticles' apoptotic and anti-proliferative effects. The MTT assay demonstrated that incorporating DAS onto PEG-PCL NPs resulted in a dose-dependent increase in cytotoxicity in A549 (lung cancer) and HeLa (cervical cancer) cells. The A549 cancer cells were analyzed for their morphology using the acridine orange/ethidium bromide (AO/EB) and DAPI staining techniques. Overall, these findings demonstrate that the polymeric PEG-PCL nanoparticle systems hold great potential as a novel therapeutic strategy for cancer treatment. 2024 Wiley Periodicals LLC. Creator An entity primarily responsible for making the resource Menon S.V.; Thakore S.; Verma A.; Dhadda S.; Chinnathambi A.; Alharbi S.A.; Bharathi M.; Arulselvan P.; Thangavelu I. Source A related resource from which the described resource is derived Journal of Applied Polymer Science, Vol-142, No. 3 Publisher An entity responsible for making the resource available John Wiley and Sons Inc Date A point or period of time associated with an event in the lifecycle of the resource 2025-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1002/app.56376" target="_blank" rel="noreferrer noopener">https://doi.org/10.1002/app.56376</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85208728559&amp;doi=10.1002%2Fapp.56376&amp;partnerID=40&amp;md5=c4e0721e78093160e743584076d26768" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85208728559&amp;doi=10.1002%2fapp.56376&amp;partnerID=40&amp;md5=c4e0721e78093160e743584076d26768</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 218995; CODEN: JAPNA Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Menon S.V., Department of Chemistry and Biochemistry, JAIN (Deemed-to-be University), Bangalore, India; Thakore S., Department of Applied Science, PIT, Parul University, Vadodara, India; Verma A., Centre of Research Impact and Outcome, Chitkara University, Rajpura, India; Dhadda S., Department of Sciences, Vivekananda Global University, Jaipur, India; Chinnathambi A., Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia; Alharbi S.A., Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia; Bharathi M., Centre for Bioinformatics, Department of Biochemistry, Karpagam Academy of Higher Education, Coimbatore, India; Arulselvan P., Department of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, India