Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource One-pot sustainable synthesis of novel pyrido[2,3-d]pyrimidinones and their evaluation for antitubercular and anticancer activity Subject The topic of the resource Anticancer activity; Antitubercular activity; MCR; Pyrido[2,3-d]pyrimidinones; Sustainable synthesis; ?-proline Description An account of the resource A novel green protocol for the construction of diversified pyrido[2,3-d]pyrimidinones was accomplished by a single-pot reaction of aryl aldehydes, Meldrum's acid, thiobarbituric acid, and ammonium acetate/aniline in H2O using ?-proline as an expeditious reusable catalyst at room temperature (26 C). Our strategy provides an innovative synthetic avenue for the construction of pyrido[2,3-d]pyrimidinones, as well as several advantages over traditional methods, including a simple procedure, shorter reaction duration, excellent yields, safe handling, easy workup, catalyst recovery, and environmental compatibility. Furthermore, the synthesised compounds were tested for their impact on different cell lines and microorganisms. Compounds 5d and 5e were particularly effective against Mycobacterium tuberculosis (antitubercular), human breast cancer cells (MCF-7), lung cancer cells (A549 and NCI-H460), and both Gram-positive (S. pyogenes) and Gram-negative (E. coli) bacteria. The derivatives with hydroxyl and nitro substitutions [5e, 5f] showed the highest potency against MCF-7, A549, and NCI-H460 cell lines, with IC50 values of 3.684.36, 3.823.41, and 11.3412.28 g/mL, respectively. 2024 The Author(s) Creator An entity primarily responsible for making the resource Tabassum S.; Ramaraj S.G.; Rajprasad J.; Sadaiyandi V.; Kumar N.; Govindaraju S. Source A related resource from which the described resource is derived Journal of Organometallic Chemistry, Vol-1025 Publisher An entity responsible for making the resource available Elsevier B.V. Date A point or period of time associated with an event in the lifecycle of the resource 2025-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.jorganchem.2024.123450" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.jorganchem.2024.123450</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85210404206&amp;doi=10.1016%2Fj.jorganchem.2024.123450&amp;partnerID=40&amp;md5=0f5d132eb2b7b9d8aa6a0284ed9acf14" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85210404206&amp;doi=10.1016%2fj.jorganchem.2024.123450&amp;partnerID=40&amp;md5=0f5d132eb2b7b9d8aa6a0284ed9acf14</a> Rights Information about rights held in and over the resource All Open Access; Hybrid Gold Open Access Relation A related resource ISSN: 0022328X; CODEN: JORCA Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Tabassum S., Department of Chemistry, Surana College - Autonomous, South End Road, Basavanagudi, Bengaluru, 560004, India; Ramaraj S.G., Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Japan, Department of Materials Physics, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMTS), Thandalam, Tamilnadu, Chennai, 602105, India; Rajprasad J., Department of Civil Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, 603203, India; Sadaiyandi V., Department of Physics and Nanotechnology, SRM Institute of Science and Technology, Kattankulathur, Tamilnadu, Chengalpattu, 603203, India; Kumar N., Department of Electronics &amp; Communication Engineering, Graphic Era Deemed to be University, Uttarakhand, Dehradun, 248002, India; Govindaraju S., Department of Sciences and Humanities, School of Engineering and Technology, Christ University, Mysore Road, Bengaluru, 560074, India