Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bougainvillea glabra-mediated synthesis of Zr?O and chitosan-coated zirconium oxide nanoparticles: Multifunctional antibacterial and anticancer agents with enhanced biocompatibility Subject The topic of the resource Chitosan coated zirconium oxide; colon cancer HCT116 cells; Zr₃O Description An account of the resource The effectiveness and safety of nanomaterials (NMs) are essential for their use in healthcare. This study focuses on creating NPs with multifunctional antibacterial and anticancer properties to combat bacterial infections and cancer disease more effectively than traditional antibiotics. This study investigates the synthesis of Zr3O and chitosan (ch) coated zirconium oxide nanoparticles (chZrO NPs) using Bougainvillea glabra (B. glabra) plant extract through a green, one-pot precipitation method. The synthesized NPs were analyzed using various techniques. Their antibacterial properties are attributed to the production of reactive oxygen species (ROS), influenced by their size, large surface area, oxygen vacancies, ion release, and diffusion capabilities. The chZrO NPs showed superior antibacterial activity compared to Zr3O and chitosan alone, with effective inhibition against both Gram-positive bacteria (S. aureus and B. subtilis) and Gram-negative bacteria (E. coli and P. aeruginosa). Additionally, anticancer studies of chZrO NPs demonstrated significant activity against colon cancer HCT116 cells with C50 values of 4.98 ?g/mL compared to chitosan and Zr3O with 9.62, 6.69 ?g/mL, while biocompatibility tests on L929 cells confirmed their safety showing 93 % cell viability compared to ch and Zr3O. These findings suggest that chZrO NPs are promising candidates for future use in clinical and healthcare applications. 2025 Elsevier B.V. Creator An entity primarily responsible for making the resource Pradeep L.; Thangavelu I.; Suriyaprakash J.; Arulselvan P.; Salmen S.H.; Chinnathambi A.; Boopathi T.S. Source A related resource from which the described resource is derived International Journal of Biological Macromolecules, Vol-300 Publisher An entity responsible for making the resource available Elsevier B.V. Date A point or period of time associated with an event in the lifecycle of the resource 2025-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.ijbiomac.2025.139609" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.ijbiomac.2025.139609</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85216029438&amp;doi=10.1016%2Fj.ijbiomac.2025.139609&amp;partnerID=40&amp;md5=30922fe9a8c60a2c79030d5efa477c67" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85216029438&amp;doi=10.1016%2fj.ijbiomac.2025.139609&amp;partnerID=40&amp;md5=30922fe9a8c60a2c79030d5efa477c67</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 1418130; PubMed ID: 39809398; CODEN: IJBMD Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Pradeep L., Department of Chemistry, Amrita School of Physical Sciences, Coimbatore, Amrita Vishwa Vidyapeetham, 641112, India, Functional Materials Laboratory, Amrita School of Engineering, Coimbatore, Amrita Vishwa Vidyapeetham, 641112, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Suriyaprakash J., Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou, 510006, China; Arulselvan P., Department of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Tamil Nadu, Chennai, 602 105, India; Salmen S.H., Department of Botany and Microbiology, College of Science, King Saud University, PO Box -2455, Riyadh, 11451, Saudi Arabia; Chinnathambi A., Department of Botany and Microbiology, College of Science, King Saud University, PO Box -2455, Riyadh, 11451, Saudi Arabia; Boopathi T.S., Department of Chemistry, Amrita School of Physical Sciences, Coimbatore, Amrita Vishwa Vidyapeetham, 641112, India, Functional Materials Laboratory, Amrita School of Engineering, Coimbatore, Amrita Vishwa Vidyapeetham, 641112, India