Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Environmentally conscious synthesis of novel pyrano[2,3-d]pyrimidines via ternary deep eutectic solvents Subject The topic of the resource Catalytic solvent; Deep eutectic solvents; Four-component reaction; Open-flask; Pyrano[2,3-d]pyrimidine; Sustainable synthesis Description An account of the resource Pyrano[2,3-d]pyrimidine and its analogues have gained considerable courtesy because of their diverse biological functions and wide-ranging applications, from pharmaceutical agents to essential natural pigments. However, synthesising pyrano[2,3-d]pyrimidine with multiple reactants is challenging and requires advanced green chemistry solutions. This study investigates the generation of thirteen new pyrano[2,3-d]pyrimidine analogues through a single-step, open-flask, multicomponent reaction (MCR) strategy involving aldehydes, phenylhydrazine, ethyl acetoacetate, and barbituric acid via deep eutectic solvents (DES). These DESs serve as environmentally friendly alternatives to traditional solvents. A ternary deep eutectic solvent (TDES) was evaluated for its catalytic solvent activity among ten different formulations. TDES-7 (5 mL) demonstrated the best performance, achieving 95 % product formation within 30 min at room temperature. Its remarkable catalytic activity and ability to produce high yields across multiple reaction cycles make it a standout choice for this application. The collaboration between MCR and TDES underscores an important blend of two significant green aspects, demonstrating their potential to achieve a green and productive sustainable synthesis method with an noble E-factor of 0.1236. 2024 Elsevier B.V. Creator An entity primarily responsible for making the resource Kumar S.L.; Tabassum S.; Govindaraju S. Source A related resource from which the described resource is derived Journal of Molecular Liquids, Vol-417 Publisher An entity responsible for making the resource available Elsevier B.V. Date A point or period of time associated with an event in the lifecycle of the resource 2025-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.molliq.2024.126651" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.molliq.2024.126651</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85211185034&amp;doi=10.1016%2Fj.molliq.2024.126651&amp;partnerID=40&amp;md5=06264166a44074bfd54945bd61b38d7e" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85211185034&amp;doi=10.1016%2fj.molliq.2024.126651&amp;partnerID=40&amp;md5=06264166a44074bfd54945bd61b38d7e</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 1677322; CODEN: JMLID Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Kumar S.L., Department of Chemistry, Christ University, Bengaluru, 560029, India; Tabassum S., Department of Chemistry, Surana College, Bengaluru, 560074, India; Govindaraju S., Department of Sciences and Humanities, Christ University, Bengaluru, 560074, India