ItemArticle

Construction of Sorafenib Tosylate and Etoposide-loaded Liposomes: A Path to Precision Liver Cancer Therapy and its Apoptosis Induction

Title
Construction of Sorafenib Tosylate and Etoposide-loaded Liposomes: A Path to Precision Liver Cancer Therapy and its Apoptosis Induction
Creator
Ganesan S.; Upadhye V.J.; Sharma N.; Arora A.; Chinnathambi A.; Alharbi S.A.; Hussein-Al-Ali S.H.; Abudoleh S.M.; Thangavelu I.
Description
Nanotechnology is an effective tool in fighting against cancer, playing a crucial role in investigating and fabricating novel anticancer drugs. Recognizing the worldwide prevalence of cancer, we combined sorafenib tosylate (ST) and etoposide (ETP) within liposomes. We assessed their ability to kill human umbilical vein endothelial cells (HUVECs) and HepG2 liver cancer cells. The liposomes effectively contained ST and ETP, exhibiting a particle size distribution below 180nm, a polydisperse index (PDI) below 0.2, a spherical shape, a strong negatively charged zeta potential, and encapsulation efficiencies of 59% for ST, 88% for ETP, and 57% for ST combined with 87% for ETP. The FTIR analysis indicates that the drugs were incorporated within liposomes. Encapsulation of the drugs in liposomes resulted in a more significant cytotoxic impact on HepG2 cells and a reduced cytotoxic impact on HUVECs. The morphological assessment of the HepG2 liver cancer cells was investigated using AO-EB and Hoechst 33258 staining methods. Apoptosis mechanisms of HepG2 cells were examined by Annexin V and PI dual staining. Furthermore, the coadministration of ST and ETP, which were enclosed in liposomes, resulted in a synergistic impact on the drugs, leading to cell death by apoptosis. 2024 Wiley-VCH GmbH.
Source
ChemistrySelect, Vol-9, No. 48
Date
2024-01-01
Publisher
John Wiley and Sons Inc
Subject
Cancer; Etoposide; Liposomes; Sorafenib tosylate; Synergism
Coverage
Ganesan S., Department of Chemistry and Biochemistry, JAIN (Deemed-to-be University), Karnataka, Bangalore, 560069, India; Upadhye V.J., Parul Institute of Applied Sciences, Parul University, PO Limda, Tal, Waghodia, Gujarat, Vadodara, 391760, India; Sharma N., Department of Sciences, Vivekananda Global University, Jaipur, 303012, India; Arora A., Centre of Research Impact and Outcome, Chitkara University, Punjab, Rajpura, 140417, India; Chinnathambi A., Department of Botany and Microbiology, College of Science, King Saud University, PO Box -2455, Riyadh, 11451, Saudi Arabia; Alharbi S.A., Department of Botany and Microbiology, College of Science, King Saud University, PO Box -2455, Riyadh, 11451, Saudi Arabia; Hussein-Al-Ali S.H., Department of Chemistry, Faculty of Sciences, Isra University, Amman, 11622, Jordan; Abudoleh S.M., Faculty of Pharmacy, Middle East University, Amman, 11831, Jordan; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bangalore, 560029, India
Rights
Restricted Access
Relation
ISSN: 23656549
Format
Online
Language
English
Type
Article

Collection

Articles

Citation

Ganesan S.; Upadhye V.J.; Sharma N.; Arora A.; Chinnathambi A.; Alharbi S.A.; Hussein-Al-Ali S.H.; Abudoleh S.M.; Thangavelu I., “Construction of Sorafenib Tosylate and Etoposide-loaded Liposomes: A Path to Precision Liver Cancer Therapy and its Apoptosis Induction,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 25, 2025, https://archives.christuniversity.in/items/show/12627.

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