Development of ?-carrageenan-based transparent and absorbent biodegradable films for wound dressing applications
- Title
- Development of ?-carrageenan-based transparent and absorbent biodegradable films for wound dressing applications
- Creator
- P A.; M R.J.; Joy J.M.; Visnuvinayagam S.; Remya S.; Mathew S.
- Description
- Wound healing remains a critical challenge in healthcare, requiring advanced wound dressings with superior properties like transparency, absorbency, and biocompatibility. However, gaps exist in the use of marine-derived biopolymers for sustainable dressings. This study addresses this gap by combining ?-carrageenan (KC) with polyvinyl pyrrolidone (PVP) to develop transparent and absorbent biodegradable films through solvent casting and lyophilization techniques. Lyophilized films exhibited superior absorbency (9.17 g/cm2) and moisture management, with a water vapour transmission rate of 3990.67 g/m2/24 h, while solvent-cast films showed 78 % transmittance, enabling wound visualization. Mechanical testing revealed high tensile strength (31.5 MPa) and folding endurance (410 folds), ensuring durability. In vitro bactericidal assays confirmed efficacy against MRSA and E. coli, and in vivo tests on Wistar rats showed complete wound healing within 16 days with 91.1 % closure, outperforming untreated controls (76.7 %). This is the first study to explore lyophilized KC-PVP films for wound dressing applications, demonstrating potential for drug release, absorbency, and biodegradability. The innovative combination of biopolymers and fabrication techniques offers a sustainable, high-performance solution for wound care. 2024 Elsevier B.V.
- Source
- International Journal of Biological Macromolecules, Vol-282
- Date
- 2024-01-01
- Publisher
- Elsevier B.V.
- Subject
- Absorbent wound dressings; Biodegradable wound dressing; Carrageenan wound dressing; Lyophilization; Solvent casting; Transparent wound dressing
- Coverage
- P A., Biochemistry and Nutrition Division, ICAR-Central Institute of Fisheries Technology, Kerala, Cochin, 682029, India, Faculty of Marine Sciences, Cochin University of Science and Technology, Kerala, Cochin, 682022, India, Department of Life Sciences, Christ University, Hosur Main Road, Bhavani Nagar, Karnataka, Bangalore, 560029, India; M R.J., Biochemistry and Nutrition Division, ICAR-Central Institute of Fisheries Technology, Kerala, Cochin, 682029, India, Faculty of Marine Sciences, Cochin University of Science and Technology, Kerala, Cochin, 682022, India; Joy J.M., Biochemistry and Nutrition Division, ICAR-Central Institute of Fisheries Technology, Kerala, Cochin, 682029, India, Faculty of Marine Sciences, Cochin University of Science and Technology, Kerala, Cochin, 682022, India, Department of Zoology, St. Teresa's College (Autonomous), Kerala, Ernakulam, 682011, India; Visnuvinayagam S., Microbiology, Fermentation and Biotechnology Division, ICAR-Central Institute of Fisheries Technology, Kerala, Cochin, 682029, India; Remya S., Fish Processing Technology, ICAR-Central Institute of Fisheries Technology, Kerala, Cochin, 682029, India; Mathew S., Biochemistry and Nutrition Division, ICAR-Central Institute of Fisheries Technology, Kerala, Cochin, 682029, India
- Rights
- Restricted Access
- Relation
- ISSN: 1418130; PubMed ID: 39500428; CODEN: IJBMD
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
P A.; M R.J.; Joy J.M.; Visnuvinayagam S.; Remya S.; Mathew S., “Development of ?-carrageenan-based transparent and absorbent biodegradable films for wound dressing applications,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 25, 2025, https://archives.christuniversity.in/items/show/12653.