Modified Montmorillonite Catalysed Ultrasonic Assisted one-pot Synthesis of Novel 2,3-dihydroisoxazolo[5,4-d] pyrimidin-4(7H)-ones as Potential Anticancer Agents
2,3-dihydroisoxazolo[5,4-d] pyrimidin-4(7H)-ones; Al2O3; Anticancer Activity; CeO2; Montmorillonite
The development of novel compounds with potential anticancer activity is imperative for combating the challenges posed by cancer. In this study, a modified montmorillonite based catalyst is employed for the synthesis of 2,3-dihydroisoxazolo[5,4-d] pyrimidin-4(7H)-ones, which are promising candidates for anticancer agents. Montmorillonite is modified using mixed metal oxides, typically Al2O3 and CeO2, by a facile approach followed by standard spectroscopic and electron microscopic characterizations. It is then employed for the one-pot synthesis of a series of 2,3-dihydroisoxazolo[5,4-d] pyrimidin-4(7H)-ones. The synthesis protocol, mediated by ultrasound, is simple, efficient, and environment friendly. The mixed metal oxide pillared montmorillonite catalyst exhibits high catalytic activity and selectivity, facilitating the formation of the desired compounds in good to excellent yields. The synthesized compounds are characterized using various spectroscopic techniques such as 1H NMR, 13C NMR and mass spectrometry. Furthermore, the anticancer activity of the synthesized compounds is evaluated against a series of cancer cell lines, revealing promising cytotoxic effects. The findings of this study highlight the potential of novel 2,3-dihydroisoxazolo[5,4-d] pyrimidin-4(7H)-ones as promising anticancer agent, warranting further investigation for their therapeutic potential. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
Anand S.; Devi K. R S.; Govindaraju S.; Tabassum S.
Catalysis Surveys from Asia, Vol-28, No. 4, pp. 435-451.
Anand S., Department of Chemistry, CHRIST (Deemed to be University), Bengaluru, 560029, India; Devi K. R S., Department of Chemistry, CHRIST (Deemed to be University), Bengaluru, 560029, India; Govindaraju S., Department of Sciences and Humanities, CHRIST (Deemed to be University), School of Engineering and Technology, Kumbalagodu, Mysore Road, Bengaluru, 560074, India; Tabassum S., Department of Chemistry, Surana College - Autonomous, South End Road, Basavanagudi, Bengaluru, 560004, India