Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Modified Montmorillonite Catalysed Ultrasonic Assisted one-pot Synthesis of Novel 2,3-dihydroisoxazolo[5,4-d] pyrimidin-4(7H)-ones as Potential Anticancer Agents Subject The topic of the resource 2,3-dihydroisoxazolo[5,4-d] pyrimidin-4(7H)-ones; Al2O3; Anticancer Activity; CeO2; Montmorillonite Description An account of the resource The development of novel compounds with potential anticancer activity is imperative for combating the challenges posed by cancer. In this study, a modified montmorillonite based catalyst is employed for the synthesis of 2,3-dihydroisoxazolo[5,4-d] pyrimidin-4(7H)-ones, which are promising candidates for anticancer agents. Montmorillonite is modified using mixed metal oxides, typically Al2O3 and CeO2, by a facile approach followed by standard spectroscopic and electron microscopic characterizations. It is then employed for the one-pot synthesis of a series of 2,3-dihydroisoxazolo[5,4-d] pyrimidin-4(7H)-ones. The synthesis protocol, mediated by ultrasound, is simple, efficient, and environment friendly. The mixed metal oxide pillared montmorillonite catalyst exhibits high catalytic activity and selectivity, facilitating the formation of the desired compounds in good to excellent yields. The synthesized compounds are characterized using various spectroscopic techniques such as 1H NMR, 13C NMR and mass spectrometry. Furthermore, the anticancer activity of the synthesized compounds is evaluated against a series of cancer cell lines, revealing promising cytotoxic effects. The findings of this study highlight the potential of novel 2,3-dihydroisoxazolo[5,4-d] pyrimidin-4(7H)-ones as promising anticancer agent, warranting further investigation for their therapeutic potential. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Creator An entity primarily responsible for making the resource Anand S.; Devi K. R S.; Govindaraju S.; Tabassum S. Source A related resource from which the described resource is derived Catalysis Surveys from Asia, Vol-28, No. 4, pp. 435-451. Publisher An entity responsible for making the resource available Springer Date A point or period of time associated with an event in the lifecycle of the resource 2024-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1007/s10563-024-09435-0" target="_blank" rel="noreferrer noopener">https://doi.org/10.1007/s10563-024-09435-0</a> <a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85203334388&doi=10.1007%2Fs10563-024-09435-0&partnerID=40&md5=429ad532898a88f26417ada14745d8f0" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85203334388&doi=10.1007%2fs10563-024-09435-0&partnerID=40&md5=429ad532898a88f26417ada14745d8f0</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 15711013 Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Anand S., Department of Chemistry, CHRIST (Deemed to be University), Bengaluru, 560029, India; Devi K. R S., Department of Chemistry, CHRIST (Deemed to be University), Bengaluru, 560029, India; Govindaraju S., Department of Sciences and Humanities, CHRIST (Deemed to be University), School of Engineering and Technology, Kumbalagodu, Mysore Road, Bengaluru, 560074, India; Tabassum S., Department of Chemistry, Surana College - Autonomous, South End Road, Basavanagudi, Bengaluru, 560004, India