Labelling of human breast cancer cells with PEG/biotin encapsulated B-type Y2O3: Eu nanophosphors for fluorescence detection
- Title
- Labelling of human breast cancer cells with PEG/biotin encapsulated B-type Y2O3: Eu nanophosphors for fluorescence detection
- Creator
- Nath S.G.; Jose J.; Bhat S.G.; Anila E.I.
- Description
- The development of non-toxic quantum dots (QDs) for fluorescence labelling of cancer cells can bring significant advancements in the disease detection. Such findings can effectively replace the conventional toxic fluorescent probes by virtue of its tunable optical characteristics. Through this work, we present the development of an efficient fluorescent probe based on B-type Y2O3: Eu QDs for labelling MCF 7 cell lines. The QDs surface was encapsulated by poly ethylene glycol (PEG) along with tumour targeting ligand, biotin. The luminescence capability of the QDs were established through photoluminescence experiments. The QDs were tested to be non-toxic through MTT assay. Fluorescence detection experiments on MCF 7 cells using the nanophosphor established the material's potential to serve as an efficient probe for cancer cell detection. 2024 Elsevier B.V.
- Source
- Inorganic Chemistry Communications, Vol-169
- Date
- 2024-01-01
- Publisher
- Elsevier B.V.
- Subject
- Fluorescence imaging; MCF 7 cells; PEG/biotin; Surface modification; Y2O3: Eu
- Coverage
- Nath S.G., Optoelectronic and Nanomaterials Research Laboratory, Department of Physics, Union Christian College, Kerala, Aluva, 683102, India; Jose J., Division of Microbiology, Department of Biosciences, Rajagiri College of Social Sciences, Kalamassery, Kerala, Kochi, 683104, India; Bhat S.G., Cochin University of Science and Technology, Kerala, Thrikkakara, 682022, India; Anila E.I., Optoelectronic and Nanomaterials Research Laboratory, Department of Physics, Union Christian College, Kerala, Aluva, 683102, India, CHRIST (Deemed to be University), Karnataka, Bengaluru, 560029, India
- Rights
- Restricted Access
- Relation
- ISSN: 13877003; CODEN: ICCOF
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Nath S.G.; Jose J.; Bhat S.G.; Anila E.I., “Labelling of human breast cancer cells with PEG/biotin encapsulated B-type Y2O3: Eu nanophosphors for fluorescence detection,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 23, 2025, https://archives.christuniversity.in/items/show/12713.