Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Chitosan stabilized platinum nanoparticles: Synthesis, characterization and cytotoxic impacts on human breast cancer cells Subject The topic of the resource Anticancer property; AO/PI dual staining; Chitosan; MTT assay; Platinum nanoparticle Description An account of the resource Platinum nanoparticles are widely studied as a nanomedicine against many of the solid tumours. Due to their promising physicochemical properties, chitosan-stabilized platinum nanoparticles may exhibit exceptional cytotoxic effects on cancer cells. This article describes the synthesis and characterization of chitosan-stabilized platinum nanoparticles (Ch-Pt NPs) through a wet chemical method and in vitro studies of their anticancer effect on human breast cancer cells (MCF-7 cell line). Different analytical methods confirmed the formation of chitosan-stabilized platinum nanoparticles. The structural and surface morphological analyses were done using XRD, FTIR, TEM, FESEM, etc. Elemental analysis was done using XPS and EDX. The hydrodynamic diameter and zeta potential were determined using DLS and zeta analyzer. These platinum nanoparticles have a spherical shape and FCC structure with an average particle size of 3.4 nm and an average hydrodynamic diameter of 248 nm. The characteristic FTIR peaks of chitosan in the sample confirmed the capping of chitosan on the surface of the Pt NPs. The surface charge estimation using a zeta potential analyzer showed ?23.8 mV, elucidating the stability and dispersity of the as-synthesized Pt NPs. The in vitro cytotoxicity study using MTT assay revealed a non-toxic behaviour on normal L929 cell lines and a severe anti-proliferative activity on a human breast cancer (MCF-7) cell line with an IC50 value of 35.60 ?g/ml after 24 h of incubation. This result indicates a better anticancer therapeutic application against human breast cancer cells for the as-synthesized chitosan-stabilized platinum nanoparticles. 2024 Elsevier B.V. Creator An entity primarily responsible for making the resource W F.A.; Jose J.; Anila E.I. Source A related resource from which the described resource is derived Materials Chemistry and Physics, Vol-326 Publisher An entity responsible for making the resource available Elsevier Ltd Date A point or period of time associated with an event in the lifecycle of the resource 2024-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.matchemphys.2024.129864" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.matchemphys.2024.129864</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85201433138&amp;doi=10.1016%2Fj.matchemphys.2024.129864&amp;partnerID=40&amp;md5=315aa4a90aebb0be02c54829e934705c" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85201433138&amp;doi=10.1016%2fj.matchemphys.2024.129864&amp;partnerID=40&amp;md5=315aa4a90aebb0be02c54829e934705c</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 2540584; CODEN: MCHPD Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant W F.A., Department of Physics and Electronics, Christ University, Karnataka, Bengaluru, 560029, India; Jose J., Division of Microbiology, Department of Biosciences, Rajagiri College of Social Sciences (Autonomous), Kerala, Cochin, 683104, India; Anila E.I., Department of Physics and Electronics, Christ University, Karnataka, Bengaluru, 560029, India