Titania Doped CDs as Effective CT-DNA Binders: A Novel Fluorescent Probe via Green Synthesis
- Title
- Titania Doped CDs as Effective CT-DNA Binders: A Novel Fluorescent Probe via Green Synthesis
- Creator
- Namrata W.N.; Joseph N.; Varghese N.; Varghese M.; Sreehari K.S.; Joy F.; Nair Y.; Manoj B.
- Description
- Carbon dots (CDs), which belong to the class of zero-dimensional carbon-based nanomaterials, have garnered significant interest owing to their wide array of applications spanning from the electronics industry to the healthcare sector. This work employs a facile, inexpensive approach to synthesize green luminescent carbon dots (J-10) from a potential medicinal plant named Justicia Wynaadensis by the one-step hydrothermal method. A nanocomposite (JT-10) of the CDs is prepared by adding TiO2 nanoparticles derived from green synthesis of Lavandula leaves. The J-10 and JT-10 are further characterized by X-ray Diffraction spectroscopy (XRD), Transmission Electron Microscopy (TEM), Raman analysis X-ray Photoelectron Spectroscopy (XPS), and Fourier transform infrared techniques (FTIR), UVvis spectroscopy, Photoluminescence (PL), and Fluorescence or PL lifetime analysis. The average size of synthesized CDs is 1.85 nm and exhibits an excitation-dependent fluorescence nature at 320 nm. PL lifetime analysis of J-10 and JT-10 is calculated to be 5.80 and 2.84 ns respectively. Offering these unique optical properties and biocompatibility, the synthesised material is suitable for investigating their binding affinity and interaction mechanisms with DNA. The use of JT-10 in DNA binding studies contributes to the development of sustainable and efficient nanomaterials for applications in biosensors, drug delivery, and gene therapy. 2024 Wiley-VCH GmbH.
- Source
- Particle and Particle Systems Characterization, Vol-41, No. 10
- Date
- 2024-01-01
- Publisher
- John Wiley and Sons Inc
- Subject
- biocompatibility; CDs; DNA affinity; fluorescent; green synthesis
- Coverage
- Namrata W.N., Nanocarbon Research Group, Materials Science Research Laboratory, Department of Physics and Electronics, Christ University, Hosur Road, Karnataka, Bangalore, 560029, India; Joseph N., Nanocarbon Research Group, Materials Science Research Laboratory, Department of Physics and Electronics, Christ University, Hosur Road, Karnataka, Bangalore, 560029, India, Department of Electronics, St Joseph's University, 36 Lalbagh Road, Karnataka, Bangalore, 5600027, India; Varghese N., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Karnataka, Bangalore, 560029, India; Varghese M., Nanocarbon Research Group, Materials Science Research Laboratory, Department of Physics and Electronics, Christ University, Hosur Road, Karnataka, Bangalore, 560029, India; Sreehari K.S., Nanocarbon Research Group, Materials Science Research Laboratory, Department of Physics and Electronics, Christ University, Hosur Road, Karnataka, Bangalore, 560029, India; Joy F., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Karnataka, Bangalore, 560029, India; Nair Y., Department of Chemistry, CHRIST (Deemed to be University), Hosur Road, Karnataka, Bangalore, 560029, India; Manoj B., Nanocarbon Research Group, Materials Science Research Laboratory, Department of Physics and Electronics, Christ University, Hosur Road, Karnataka, Bangalore, 560029, India
- Rights
- Restricted Access
- Relation
- ISSN: 9340866; CODEN: PPCHE
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Namrata W.N.; Joseph N.; Varghese N.; Varghese M.; Sreehari K.S.; Joy F.; Nair Y.; Manoj B., “Titania Doped CDs as Effective CT-DNA Binders: A Novel Fluorescent Probe via Green Synthesis,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 25, 2025, https://archives.christuniversity.in/items/show/12803.