Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Facile engineering of aptamer-coupled silk fibroin encapsulated myogenic gold nanocomposites: investigation of antiproliferative activity and apoptosis induction Subject The topic of the resource Apoptosis; Aptamer, gold nanocomposites; Liver cancer; Silk fibroin Description An account of the resource Nanocomposites selectively induce cancer cell death, holding potential for precise liver cancer treatment breakthroughs. This study assessed the cytotoxicity of gold nanocomposites (Au NCs) enclosed within silk fibroin (SF), aptamer (Ap), and the myogenic Talaromyces purpureogenus (TP) against a human liver cancer cell (HepG2). The ultimate product, Ap-SF-TP@Au NCs, results from a three-step process. This process involves the myogenic synthesis of TP@Au NCs derived from TP mycelial extract, encapsulation of SF on TP@Au NCs (SF-TP@Au NCs), and the conjugation of Ap within SF-TP@Au NCs. The synthesized NCs are analyzed by various characteristic techniques. Ap-SF-TP@Au NCs induced potential cell death in HepG2 cells but exhibited no cytotoxicity in non-cancerous cells (NIH3T3). The morphological changes in cells were examined through various biochemical staining methods. Thus, Ap-SF-TP@Au NCs emerge as a promising nanocomposite for treating diverse cancer cells. The Author(s), under exclusive licence to Springer Nature B.V. 2024. Creator An entity primarily responsible for making the resource Elayappan P.K.; Kandasamy K.; Sasikumar V.; Bharathi M.; Hirad A.H.; Alarfaj A.A.; Arulselvan P.; Jaganathan R.; Ravindran R.; Suriyaprakash J.; Thangavelu I. Source A related resource from which the described resource is derived Biotechnology Letters, Vol-46, No. 5, pp. 871-885. Publisher An entity responsible for making the resource available Springer Science and Business Media B.V. Date A point or period of time associated with an event in the lifecycle of the resource 2024-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1007/s10529-024-03491-2" target="_blank" rel="noreferrer noopener">https://doi.org/10.1007/s10529-024-03491-2</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191726075&amp;doi=10.1007%2Fs10529-024-03491-2&amp;partnerID=40&amp;md5=3f12e6d5dd240ec3218a0435d39e7c4e" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191726075&amp;doi=10.1007%2fs10529-024-03491-2&amp;partnerID=40&amp;md5=3f12e6d5dd240ec3218a0435d39e7c4e</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 1415492; PubMed ID: 38676857; CODEN: BILED Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Elayappan P.K., Department of Biochemistry, Vivekanandha College of Arts and Sciences for Women (Autonomous), Elayampalayam, Tiruchengode, Tamil Nadu, Namakkal, 637205, India; Kandasamy K., Department of Biochemistry, Vivekanandha College of Arts and Sciences for Women (Autonomous), Elayampalayam, Tiruchengode, Tamil Nadu, Namakkal, 637205, India; Sasikumar V., Department of Biochemistry, K.S.Rangasamy College of Arts and Science, Tiruchengode, Tamil Nadu, Namakkal, 637215, India; Bharathi M., Center for Bioinformatics, Department of Biochemistry, Karpagam Academy of Higher Education, Tamil Nadu, Coimbatore, 641021, India; Hirad A.H., Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia; Alarfaj A.A., Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia; Arulselvan P., Department of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Tamil Nadu, Chennai, 602 105, India; Jaganathan R., Preclinical Department, Faculty of Medicine, Universiti Kuala Lumpur, Royal College of Medicine Perak (UniKL-RCMP), Perak, Ipoh, 30450, Malaysia; Ravindran R., Preclinical Department, Faculty of Medicine, Universiti Kuala Lumpur, Royal College of Medicine Perak (UniKL-RCMP), Perak, Ipoh, 30450, Malaysia; Suriyaprakash J., Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou, 510006, China; Thangavelu I., Department of Chemistry, CHRIST (Deemed to Be University), Bangalore, 560029, India