Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Elucidating the interplay of PPAR gamma inhibition and energy demand in adriamycin-induced cardiomyopathy: In Vitro and In Vivo perspective Subject The topic of the resource Adriamycin; cancer; cardiotoxicity; oxidative stress; PPAR? Description An account of the resource Adriamycin is an anticancer anthracycline drug that inhibits the progression of topoisomerase II activity and causes apoptosis. The effective clinical application of the drug is very much limited by its adverse drug reactions on various tissues. Most importantly, Adriamycin causes cardiomyopathy, one of the life-threatening complications of the drug. Altered expression of PPAR? in adipocytes inhibited the glucose and fatty acids uptake by down regulating GLUT4 and CD36 expression and causes cardiotoxicity. Therefore, the influence of Adriamycinin cardiac ailments was investigated in vivo and in vitro. Adriamycin treated rats showed altered ECG profile, arrhythmic heartbeat with the elevated levels of CRP and LDH. Dysregulated lipid profiles with elevated levels of cholesterol and triglycerides were also observed. Possibilities of cardiac problems due to cardiomyopathy were analyzed through histopathology. Adriamycin treated rats showed no signs for atheromatous plaque formation in aorta but disorganized cardiomyocytes with myofibrillar loss and inflammation in heart tissue, indicative of cardiomyopathy. Reduced levels of antioxidant enzymes confirmed the incidence of oxidative stress. Adriamycin treatment significantly reduced glucose and insulin levels, creating energy demand due to decreased glucose and insulin levels with increased fatty acid accumulation, ultimately resulting in oxidative stress mediated cardiomyopathy. Since PPARs play a vital role in regulating oxidative stress, the effect of Adriamycin on PPAR? was analyzed by western blot. Adriamycin downregulated PPAR? in a dose-dependent manner in H9C2 cells in vitro. Overall, our study suggests that Adriamycin alters glucose and lipid metabolism via PPAR? inhibition that leads to oxidative stress and cardiomyopathy that necessitates a different therapeutic approach. 2024 Wiley Periodicals LLC. Creator An entity primarily responsible for making the resource Seenivasan K.; Arunachalam S.; Tirupathi Pichiah P.B.; Vasan S.B.; Venkateswaran M.R.; Siva D.; Gothandam J.; Achiraman S. Source A related resource from which the described resource is derived Journal of Biochemical and Molecular Toxicology, Vol-38, No. 10 Publisher An entity responsible for making the resource available John Wiley and Sons Inc Date A point or period of time associated with an event in the lifecycle of the resource 2024-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1002/jbt.23855" target="_blank" rel="noreferrer noopener">https://doi.org/10.1002/jbt.23855</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85205151987&amp;doi=10.1002%2Fjbt.23855&amp;partnerID=40&amp;md5=97fa69011cf37fe16f064a25212a980e" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85205151987&amp;doi=10.1002%2fjbt.23855&amp;partnerID=40&amp;md5=97fa69011cf37fe16f064a25212a980e</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 10956670; PubMed ID: 39328005; CODEN: JBMTF Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Seenivasan K., Department of Environmental Biotechnology, Bharathidasan University, Tamil Nadu, Tiruchirappalli, India; Arunachalam S., Department of Life Sciences, School of Sciences, CHRIST University, Karnataka, Bengaluru, India; Tirupathi Pichiah P.B., Department of Environmental Biotechnology, Bharathidasan University, Tamil Nadu, Tiruchirappalli, India; Vasan S.B., School of Life Sciences, Bharathidasan University, Tamil Nadu, Tiruchirappalli, India; Venkateswaran M.R., Department of Environmental Biotechnology, Bharathidasan University, Tamil Nadu, Tiruchirappalli, India; Siva D., Centre for Laboratory Animal Technology and Research, Sathyabama Institute of Science and Technology, Tamil Nadu, Chennai, India; Gothandam J., Department of Environmental Biotechnology, Bharathidasan University, Tamil Nadu, Tiruchirappalli, India; Achiraman S., Department of Environmental Biotechnology, Bharathidasan University, Tamil Nadu, Tiruchirappalli, India