Hepatoprotective activity of Peltophorum pterocarpum leaf and bark in the isoniazid and rifampicin-induced hepatotoxic rats
Hepatoprotective; Isoniazid; Liver enzymes; Mitochondrial enzymes; Phytomedicines; Rifampicin
Background: In recent years, various phytomedicines have been used in the treatment of hepatic disorders. The aim of this study is to find out whether Peltophorum pterocarpum bark and leaves can help rats that have been exposed to isoniazid and rifampicin-induced hepatotoxicity. Materials and Methods: The rats were divided into 10 groups each with 6 rats. The liver damage is induced by isoniazid and rifampicin. The leaf and bark of P. pterocarpum extracted with ethanol are freshly mixed in sterile water (100, 200 and 400 mg/kg body weight), and given to rats orally in the early morning as a single dosage per day until the study period. The animals were sacrificed and the tissue and serum samples were collected for further investigations. Results: The liver damage induced by isoniazid and rifampicin altered the various biochemical parameters levels, but after the treatment of P. pterocarpum barks and leaves the levels were significantly altered when compared to the negative control rats. The drug silymarin was used as a standard. Conclusion: The extracts have the protective effect of liver markers and membrane-bound enzymes against the toxin-treated rats. This result highlights the hepatoprotective properties of the leaves and barks of the plant in a similar manner and the formulation (Group 10) have high beneficial effects than other groups. 2024
Babu M.J.; Manikandan R.; Balamuralikrishnan B.; Kathirvel B.; Rajagopal R.; Alfarhan A.; Meyyazhagan A.; Vijaya Anand A.
Journal of King Saud University - Science, Vol-36, No. 8
All Open Access; Hybrid Gold Open Access
https://doi.org/10.1016/j.jksus.2024.103282 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85195206863&doi=10.1016%2fj.jksus.2024.103282&partnerID=40&md5=8077ee40b9ea8c43fcb562a144f456d5
Babu M.J., Department of Biochemistry, Bharathiar University, Tamil Nadu, Coimbatore 641 046, India; Manikandan R., Department of Biochemistry, Shrimati Indira Gandhi College, Tamil Nadu, Trichirappalli 620 002, India; Balamuralikrishnan B., Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, 05006, South Korea; Kathirvel B., Department of Human Genetics and Molecular Biology, Bharathiar University, Tamil Nadu, Coimbatore 641 046, India; Rajagopal R., Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia; Alfarhan A., Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia; Meyyazhagan A., Department of Life Sciences, Christ University, Karnataka, Bengaluru, 560029, India; Vijaya Anand A., Department of Human Genetics and Molecular Biology, Bharathiar University, Tamil Nadu, Coimbatore 641 046, India