Mentha spicata assisted AgCuO nanocomposite enables anti-diabetic and vitamin-C sensing activities
- Title
- Mentha spicata assisted AgCuO nanocomposite enables anti-diabetic and vitamin-C sensing activities
- Creator
- Shahzad N.; Aziz Ibrahim I.A.; R Alzahrani A.; Shahid I.; Falemban A.H.; Alanazi I.M.; A Bamagous G.; Al-Ghamdi S.S.; Imam M.T.; Mohsin N.; Thangavelu I.; Arulselvan P.
- Description
- Diabetes mellitus (DM), a multifactorial chronic health condition, affects a sizable portion of the global population, and more people are expected to contract it in the future, according to the World Health Organisation (WHO). Diabetes mellitus can be treated with conventional drugs, but most of the medications have a variety of side effects. The use of nanocomposites (NCs) to treat diabetes has been prioritized in this scenario. In this study, AgCuO NCs were synthesized using a green method using Mentha spicata leaf extract and their physicochemical properties were investigated with a variety of analytical techniques. According to an extensive in vivo and in vitro analysis of the biological activities of as-synthesized AgCuO NCs, AgCuO NCs possess effective antibacterial, anti-diabetic, and anti-hyperlipidemic characteristics. When AgCuO NCs are administered to STZ-induced animals in a concentration-based manner, the blood levels of inflammatory and liver marker enzymes are reduced and antioxidant enzyme levels are increased. Besides, AgCuO NCs exhibit excellent sensing activity with a limit of detection of 86 nM against Vitamin-C. This study reveals that AgCuO NCs derived from Mentha spicata may, therefore, prove to be a very successful anti-diabetic and biosensor candidate in the future. 2024 Elsevier B.V.
- Source
- Journal of Drug Delivery Science and Technology, Vol-99
- Date
- 2024-01-01
- Publisher
- Editions de Sante
- Subject
- AgCuO; Anti-diabetics; Biosensor; Diabetes mellitus; Green synthesis; nanocomposite; Phytosynthesis
- Coverage
- Shahzad N., Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia; Aziz Ibrahim I.A., Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia; R Alzahrani A., Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia; Shahid I., Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia; Falemban A.H., Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia; Alanazi I.M., Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia; A Bamagous G., Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia; Al-Ghamdi S.S., Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia; Imam M.T., Department of Clinical Pharmacy, Faculty of Pharmacy, Al-Kharj University, Al-Kharj, Saudi Arabia; Mohsin N., Department of Clinical Pharmacy, Faculty of Pharmacy, Najran University, Najran, Saudi Arabia; Thangavelu I., Department of Chemistry, CHRIST (deemed to Be University), Tamil Nadu, Bangalore, India; Arulselvan P., Department of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Tamil Nadu, Chennai, 602 105, India
- Rights
- Restricted Access
- Relation
- ISSN: 17732247; CODEN: JDDSA
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Shahzad N.; Aziz Ibrahim I.A.; R Alzahrani A.; Shahid I.; Falemban A.H.; Alanazi I.M.; A Bamagous G.; Al-Ghamdi S.S.; Imam M.T.; Mohsin N.; Thangavelu I.; Arulselvan P., “Mentha spicata assisted AgCuO nanocomposite enables anti-diabetic and vitamin-C sensing activities,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 28, 2025, https://archives.christuniversity.in/items/show/12870.