Structural modification of electrophilic group substituted phenyldiazenyl derivatives for antitubercular application
- Title
- Structural modification of electrophilic group substituted phenyldiazenyl derivatives for antitubercular application
- Creator
- Almehizia A.A.; Naglah A.M.; El-Mowafi S.A.; Lobo P.L.; Patil P.; Naik L.
- Description
- In the present work, four electrophilic group substitute phenyldiazenyl derivatives were synthesized using an electrophilic substitution reaction. The physicochemical analysis was carried out using FT-IR, 1H NMR, and HR-MS data. The photophysical studies were carried out using theoretical methods. Density functional theory was employed to illustrate the electronic and optical characteristics of the synthesized compounds. The HOMO-LUMO energies were theoretically computed in different solvents using Gaussian 09W software and results are compared with the experimental values. The molecule PT4 shows highest bandgap of 4.497eV. Further, the global chemical reactivity descriptors were used to determined nature of chemical reactivity. The anti-tubercular activity was evaluated using invitro and molecular docking techniques and results reveal that barbituric acid coupled with phenyldiazenyl displayed excellent anti-tubercular activity compared with the standard Gentamycin. 2024 Indian Chemical Society
- Source
- Journal of the Indian Chemical Society, Vol-101, No. 9
- Date
- 2024-01-01
- Publisher
- Elsevier B.V.
- Subject
- Antitubercular activity; DFT study; GCRD; Phenyldiazenyl derivatives; Photophysical properties
- Coverage
- Almehizia A.A., Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia; Naglah A.M., Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia; El-Mowafi S.A., Peptide Chemistry Department, National Research Centre, Cairo, Dokki, 12622, Egypt; Lobo P.L., Department of Chemistry, Maharani's Science College for Women, Maharani Cluster University, Karnataka, Bengaluru, 560 001, India; Patil P., Department of Studies in Chemistry, Davangere University, Shivagangothri, Karnataka, Davanagere, 577 007, India; Naik L., Department of Physics and Electronics, CHRIST (Deemed to be University), Bengaluru, 560029, India
- Rights
- Restricted Access
- Relation
- ISSN: 194522; CODEN: JICSA
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Almehizia A.A.; Naglah A.M.; El-Mowafi S.A.; Lobo P.L.; Patil P.; Naik L., “Structural modification of electrophilic group substituted phenyldiazenyl derivatives for antitubercular application,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 25, 2025, https://archives.christuniversity.in/items/show/12887.