Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Folic Acid-Modified B-Type Y2O3:Eu3+ Quantum Dots: A Bright Approach to Fluorescence Imaging of Cancer Cells Subject The topic of the resource cancer cell imaging; Eu doping; monoclinic yttria; PEG-folic acid capping; photoluminescence Description An account of the resource Clinical applications of nanophosphors have gained extensive interest in research areas such as bioimaging and targeted drug delivery. The development of nontoxic semiconductor quantum dots (QDs), which can replace the conventional fluorescent probes, can bring significant developments in the bioimaging industry. This work reports the synthesis of monoclinic Y2O3:Eu QDs, without and with surface functionalization using PEG/folic acid at low temperature and its application in live cancer cell imaging. The synthesized quantum dots show sharp absorption in the short UV region and an intense red emission at 614 nm. Concentration-dependent optical properties are studied in detail, and color purity is measured. Transmission electron microscopy substantiates the monoclinic structure, crystalline nature, and the lower particle dimensions essential for the biological applications. The surface-modified sample is characterized for its structural and luminescence properties. Biocompatibility was ensured by performing MTT Assay on L6 skeletal muscle cell lines (normal) and MCF 7 cell lines (cancer) for the samples without and with surface modification, respectively. Fluorescence detection experiments on SKMEL cells using an uncapped sample prove the suitability of the material as a fluorescent probe. The effect of surface functionalization on imaging results was established by carrying out fluorescence detection experiments on MCF 7 cells using PEG-folic acid-functionalized sample, which resulted in enhanced cell uptake, specific binding, and bright fluorescence emission. Thus, this work authenticates the suitability of the material to be used as a reliable nanophosphor and an efficient fluorescent probe for imaging cancer cells. 2024 American Chemical Society. Creator An entity primarily responsible for making the resource Nath S.G.; Jose J.; Bhat S.G.; Anila E.I. Source A related resource from which the described resource is derived ACS Applied Nano Materials, Vol-7, No. 17, pp. 21160-21169. Publisher An entity responsible for making the resource available American Chemical Society Date A point or period of time associated with an event in the lifecycle of the resource 2024-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1021/acsanm.4c04510" target="_blank" rel="noreferrer noopener">https://doi.org/10.1021/acsanm.4c04510</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85201912258&amp;doi=10.1021%2Facsanm.4c04510&amp;partnerID=40&amp;md5=6e3bff9248ec837c636a07a0a5908459" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85201912258&amp;doi=10.1021%2facsanm.4c04510&amp;partnerID=40&amp;md5=6e3bff9248ec837c636a07a0a5908459</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 25740970 Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Nath S.G., Optoelectronics and Nanomaterials Research Laboratory, Department of Physics, Union Christian College, Kerala, Aluva, 683102, India; Jose J., Department of Biosciences, Rajagiri College of Social Sciences, Kalamassery, Kerala, Kochi, 683104, India; Bhat S.G., Cochin University of Science and Technology, Kerala, Thrikkakara, 682022, India; Anila E.I., Optoelectronics and Nanomaterials Research Laboratory, Department of Physics, Union Christian College, Kerala, Aluva, 683102, India, CHRIST (Deemed to be University), Karnataka, Bengaluru, 560029, India