Synthesis, Characterization and Analytical Applications of Disubstituted urea/thiourea derivatives

Title

Synthesis, Characterization and Analytical Applications of Disubstituted urea/thiourea derivatives

Creator

Kumari Rekha

Description

Two Urea/Thiourea derivatives have been synthesized in good yields from Urea/Thiourea and aniline in dry media conditions by using p-TSA as catalyst under microwave assisted method and they are characterized by IR and NMR spectral analysis. There are several advantages of foresaid catalyst like rate enhancements, higher yields, easy work-up procedure and energy efficient. The reaction has been done under solvent free condition having short reaction time period, increased safety and economic advantages. This Thiourea derivatives reagent has been used for the spectrophotometric determination of palladium. The results obtained by the proposed method is accurate reproducible. The proposed method has been successfully applied for the determination of palladium(II) in some synthetic mixtures of alloy samples and mineral. This dissertation contain five chapters Chapter 1 includes significance of Urea/Thiourea derivatives, green experimental protocol, heterogeneous catalysts. It also includes Objective of the study which is a develop a new methodology for the synthesis of Urea/Thiourea derivatives. Chapter 2 includes review of literature on the synthesis of Urea/Thiourea derivatives by different varieties of techniques. Different catalysts are used for that technique. Chapter 3 describes about materials and experimental procedures which are used in this synthesis . Chapter 4 deals with the various characterization results of Urea/Thiourea derivatives. It also describes the application of N,N??-diphenylthiourea in the trace level determination of palladium. Chapter 5 gives the summary and conclusion of the present study. It also gives the future scope of the present work. Furthermore, short reaction times, good yields of products, mild reaction conditions, and easy work-up/purification are the other noteworthy advantages which make this method a valid contribution to the existing methodologies is given in this chapter. Key works: Urea/Thiourea derivatives, p-TSA, MWI, IR, NMR, and Palladium.

Source

Department of Chemistry

Date

2013