Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Facile construction of gefitinib-loaded zeolitic imidazolate framework nanocomposites for the treatment of different lung cancer cells Subject The topic of the resource apoptosis; gefitinib; lung cancer; nanocomposites; zeolitic imidazolate framework Description An account of the resource Gefitinib (GET) is a revolutionary targeted treatment inhibiting the epidermal growth factor receptor's tyrosine kinase action by competitively inhibiting the ATP binding site. In preclinical trials, several lung cancer cell lines and xenografts have demonstrated potential activity with GET. Response rates neared 25% in preclinical trials for non-small cell lung cancer. Here, we describe the one-pot synthesis of GET@ZIF-8 nanocomposites (NCs) in pure water, encapsulating zeolitic imidazolate framework 8 (ZIF-8). This method developed NCs with consistent morphology and a loading efficiency of 9%, resulting in a loading capacity of 20wt%. Cell proliferation assay assessed the anticancer effect of GET@ZIF-8 NCs on A549 and H1299 cells. The different biochemical staining (Calcein-AM and PI and 4?,6-Diamidino-2-phenylindole nuclear staining) assays assessed the cell death and morphological examination. Additionally, the mode of apoptosis was evaluated by mitochondrial membrane potential (??m) and reactive oxygen species. Therefore, the study concludes that GET@ZIF-8 NCs are pledged to treat lung cancer cells. 2024 International Union of Biochemistry and Molecular Biology, Inc. Creator An entity primarily responsible for making the resource Aiyasamy K.; Ramasamy M.; Hirad A.H.; Arulselvan P.; Jaganathan R.; Suriyaprakash J.; Thangavelu I.; Alarfaj A.A. Source A related resource from which the described resource is derived Biotechnology and Applied Biochemistry, Vol-71, No. 4, pp. 896-908. Publisher An entity responsible for making the resource available John Wiley and Sons Inc Date A point or period of time associated with an event in the lifecycle of the resource 2024-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1002/bab.2585" target="_blank" rel="noreferrer noopener">https://doi.org/10.1002/bab.2585</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85190431877&amp;doi=10.1002%2Fbab.2585&amp;partnerID=40&amp;md5=e9da2c579f8a809f012961728cb080cc" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85190431877&amp;doi=10.1002%2fbab.2585&amp;partnerID=40&amp;md5=e9da2c579f8a809f012961728cb080cc</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 8854513; PubMed ID: 38594878; CODEN: BABIE Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Aiyasamy K., Department of Biochemistry, Vivekanandha College of Arts and Sciences for Women (Autonomous), Tiruchengode, Tamil Nadu, Namakkal, India; Ramasamy M., Department of Biochemistry, Vivekanandha College of Arts and Sciences for Women (Autonomous), Tiruchengode, Tamil Nadu, Namakkal, India; Hirad A.H., Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia; Arulselvan P., Department of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Tamil Nadu, Chennai, India; Jaganathan R., Preclinical Department, Faculty of Medicine, Universiti Kuala Lumpur, Royal College of Medicine Perak (UniKL-RCMP), Perak, Malaysia; Suriyaprakash J., Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou, China; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, India; Alarfaj A.A., Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia