Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Psidium guajava-mediated green synthesis of Fe-doped ZnO and Co-doped ZnO nanoparticles: a comprehensive study on characterization and biological applications Subject The topic of the resource Antibacterial activity; Anticancer activity; Green synthesis; Modified ZnO; Transition metal ions Description An account of the resource The efficacy of nanoparticles (NPs) in healthcare applications hinges on their biocidal activity and biocompatibility. This research is dedicated to green-synthesized NPs with potent biocidal properties, aiming for high inhibition rates in bacterial infections and offering a multifunctional application, including potential use in anticancer therapy, in comparison to traditional antibiotics. The present study focuses on synthesis of zinc oxide (ZnO) nanoparticles (NPs), including iron-doped ZnO (GZF) and cobalt-doped ZnO (GZC), using the green co-precipitation method involving Psidium guajava (P. guajava) leaf extract. The physicochemical properties of the synthesized NPs were analyzed using various characterization techniques. The antibacterial and anticancer activity depends on the generation of reactive oxygen species (ROS), particle size, surface area, oxygen vacancy, Zn2+ release, and diffusion ability. The antibacterial activity of the synthesized NPs was tested against various Gram-positive (Streptococcus pneumoniae (S. pneumoniae), Bacillus subtilis (B. subtilis) and Gram-negative (Klebsiella pneumoniae (K. pneumoniae), and Pseudomonas aeruginosa (P. aeruginosa) bacterial strains. The zone of inhibition showed higher activity of GZC (1820mm) compared to GZF (1619mm) and GZO (1115mm) NPs. Moreover, anticancer studies against blood cancer cell line (MOLT-4) showed half-maximal inhibitory concentration of 11.3?g/mL for GZC compared to GZF and GZO NPs with 12.1?g/mL and 12.5?g/mL, respectively. Cytotoxicity assessments carried out on the fibroblast L929 cell line indicated that GZO, GZF, and GZC NPs demonstrated cell viabilities of 85.43%, 86.66%, and 88.14%, respectively. Thus, green-synthesized GZC NPs hold promise as multifunctional agents in the biomedical sector. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Creator An entity primarily responsible for making the resource Boopathi T.S.; Suksom S.; Suriyaprakash J.; Hirad A.H.; Alarfaj A.A.; Thangavelu I. Source A related resource from which the described resource is derived Bioprocess and Biosystems Engineering, Vol-47, No. 8, pp. 1271-1291. Publisher An entity responsible for making the resource available Springer Science and Business Media Deutschland GmbH Date A point or period of time associated with an event in the lifecycle of the resource 2024-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1007/s00449-024-03002-7" target="_blank" rel="noreferrer noopener">https://doi.org/10.1007/s00449-024-03002-7</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85189626666&amp;doi=10.1007%2Fs00449-024-03002-7&amp;partnerID=40&amp;md5=4c0a1182157f539af905ed3003a03402" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85189626666&amp;doi=10.1007%2fs00449-024-03002-7&amp;partnerID=40&amp;md5=4c0a1182157f539af905ed3003a03402</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 16157591; PubMed ID: 38573335; CODEN: BBEIB Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Boopathi T.S., Department of Chemistry, Amrita School of Physical Sciences, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India, Functional Materials Laboratory, Amrita School of Engineering, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India; Suksom S., Department of Public Administration, Western University, Bangkok, Thailand; Suriyaprakash J., Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou, 510006, China; Hirad A.H., Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia; Alarfaj A.A., Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India