Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Imidazopyridine Hydrazine Conjugates as Potent Anti-TB Agents with their Docking, SAR, and DFT Studies Subject The topic of the resource and X-ray; Anti-TB; DFT studies; Docking; Imidazopyridine Description An account of the resource Novel imidazopyridines hydrazine conjugates were designed and synthesized for their anti-tubercular (anti-TB) activity. A cytotoxicity assay was conducted with Vero cells to determine the safety profile of the most effective compounds. It was found that compound (IA3) (MIC=0.78 ?M) and (IA8) (MIC=1.12 ?M) were nearly 3.7 and 2.5 times more active than pyrazinamide. Based on Density functional theory (DFT), these molecules exhibited better charge transfer between molecular orbital's, which made them suitable for biological applications. Molecular docking on Mycobacterium tuberculosis InhA bound to NITD-916 (PDB: 4R9S) revealed that compounds possessed greater binding affinity towards proteins. In addition, the most active anti-TB compounds (IA3) and (IA8) exhibited high levels of interaction with the target protein and exceptional safety profile, suggesting they may prove to be effective leads for new drugs. 2024 Wiley-VCH GmbH. Creator An entity primarily responsible for making the resource Soumyashree D.K.; Reddy D.S.; Sunitha Kumari M.; Ravikumar R.; Kumar A.; Nagarajaiah H.; Vidya G.; Naik L.; Al-Asbahi B.A.; Kadam N.; Shanavaz H.; Padmashali B. Source A related resource from which the described resource is derived ChemistrySelect, Vol-9, No. 20 Publisher An entity responsible for making the resource available John Wiley and Sons Inc Date A point or period of time associated with an event in the lifecycle of the resource 2024-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1002/slct.202400937" target="_blank" rel="noreferrer noopener">https://doi.org/10.1002/slct.202400937</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85194035562&amp;doi=10.1002%2Fslct.202400937&amp;partnerID=40&amp;md5=eb495cbe7e2e775283c92bd4a1040212" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85194035562&amp;doi=10.1002%2fslct.202400937&amp;partnerID=40&amp;md5=eb495cbe7e2e775283c92bd4a1040212</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 23656549 Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Soumyashree D.K., Department of Chemistry, School of Basic Science, Rani Channamma University, Belagavi, Karnataka, 591156, India; Reddy D.S., Centre for Nano and Material Sciences, Jain (Deemed-to-be University), Jain Global Campus, Kanakapura, Bangalore, Karnataka, 562112, India; Sunitha Kumari M., Department of Physics, Yuvaraja's College, University of Mysore, Mysuru, Karnataka, 570005, India; Ravikumar R., Department of Physics, Yuvaraja's College, University of Mysore, Mysuru, Karnataka, 570005, India; Kumar A., Centre for Nano and Material Sciences, Jain (Deemed-to-be University), Jain Global Campus, Kanakapura, Bangalore, Karnataka, 562112, India; Nagarajaiah H., Department of Chemistry, School of Applied Sciences, REVA University, Yelahanka, Bangalore, 560064, India; Vidya G., Department of Chemistry, Dayananda Sagar College of Engineering, SM Hills, Kumaraswamy layout, Bengaluru, Karnataka, 560111, India; Naik L., Department of Physics and Electronics, CHRIST University, Bangalore, 560029, India; Al-Asbahi B.A., Department of Physics &amp; Astronomy, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia; Kadam N., Sangolli Rayanna First Grade Constituent College, Belagavi, 5900017, India; Shanavaz H., Department of Chemistry, Faculty of Engineering and Technology, Jain University, Jain Global Campus, Jakkasandra Post, Bangalore, 562112, India; Padmashali B., Department of Chemistry, School of Basic Science, Rani Channamma University, Belagavi, Karnataka, 591156, India