Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Escitalopram treatment ameliorates chronic immobilization stress-induced depressive behavior and cognitive deficits by modulating BDNF expression in the hippocampus Subject The topic of the resource cronic stress; escitalopram; Hippocampus; neuronal plasticity; neurotrophic factors Description An account of the resource Major depressive disorder (MDD) affects 21% of the global population. Chronic exposure to stressful situations may affect the onset, progression, and biochemical alterations underlying MDD and associated cognitive impairments. Patients exhibiting MDD are mainly treated with several antidepressants; one is escitalopram, a selective serotonin reuptake inhibitor. However, whether or not it mitigates chronic stress-induced cognitive deficits is unknown. The present study exposed rats to chronic immobilization stress (CIS) 2 hours/day for 10 days. Then, escitalopram (5 mg and 10 mg/kg i.p.) was administered for 14 days and subjected to the elevated plus maze, open field test, forced swim test, sucrose preference test, and radial arm maze task. A different set of animals were used to assess the vascular endothelial growth factor (VEGF), glial fibrillary acidic protein (GFAP), and brain derived neurotrophic factor (BDNF) levels in the hippocampus, frontal cortex, and amygdale. Our data suggest that escitalopram significantly protected CIS-induced spatial learning and memory deficits, behavioral depression, and anxiety. Furthermore, escitalopram (10 mg/kg) shows a remarkable recovery of dentate gyrus and hippocampal atrophy. In addition, the restoration of molecular markers BDNF, VEGF, and GFAP expression is also implicated in the neuroprotective mechanisms of escitalopram. Our results suggested that esciatlorpam restores cognitive impairments in stressed rats by regulating neurotrophic factors and astrocytic markers. 2024 Shilpa Borehalli Mayegowda et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/). All Rights Reserved. Creator An entity primarily responsible for making the resource Mayegowda S.B.; Rao B.V.; Rao B.S.R.S. Source A related resource from which the described resource is derived Journal of Applied Pharmaceutical Science, Vol-14, No. 3, pp. 170-182. Publisher An entity responsible for making the resource available Open Science Publishers LLP Inc. Date A point or period of time associated with an event in the lifecycle of the resource 2024-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.7324/JAPS.2024.158094" target="_blank" rel="noreferrer noopener">https://doi.org/10.7324/JAPS.2024.158094</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85187495805&amp;doi=10.7324%2FJAPS.2024.158094&amp;partnerID=40&amp;md5=8be823256e161a759c257e6086ed9a8f" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85187495805&amp;doi=10.7324%2fJAPS.2024.158094&amp;partnerID=40&amp;md5=8be823256e161a759c257e6086ed9a8f</a> Rights Information about rights held in and over the resource All Open Access; Gold Open Access Relation A related resource ISSN: 22313354 Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Mayegowda S.B., Department of Psychology, Christ Deemed to be University, Bengaluru, India; Rao B.V., Department of Pharmacology, KLE College of Pharmacy, KLE Academy of Higher Education and Research (KAHER), Bengaluru, India; Rao B.S.R.S., Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, India