Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Synthesis of SnO2-Sodium alginate-polyethylene glycol-crocin nanocomposite for enhanced antimicrobial and anticancer activity Subject The topic of the resource Apoptosis; Biopolymers; Cervical cancer; Crocin; Tin oxide Description An account of the resource Bacteria and fungi contribute to antibiotic resistance, posing a growing threat to human health, while cervical cancer remains a significant health concern, impacting women's well-being and mortality rates worldwide. In the present work, the efficiency of formulated tin oxide-sodium alginate-polyethylene glycol-crocin nanocomposites (SnO2-SAPEG-Cro-NCs) on antimicrobial as well as growth inhibition and apoptosis induction in cervical cancer cells was evaluated. The developed nanostructure was exposed to several spectroscopic investigations, including UV, FTIR, XRD, PL, EDAX, DLS studies, and FESEM structural observation. The results of the antimicrobial study revealed increased inhibition zones from 8.5 to 16 mm around the SnO2-SAPEG-Cro-NCs treatment over different pathogens, which proves its antimicrobial efficacy. The findings of the MTT study demonstrated that SnO2-SAPEG-Cro-NCs (0.510 ?g/mL) treatment remarkably inhibited the HeLa cell viability with IC50 concentration of 5 ?g/mL. The SnO2-SAPEG-Cro-NCs-treated HeLa cells also revealed increased intracellular ROS generation at 5 and 7.5 ?g/mL, which may facilitate oxidative stress-mediated cell death. Further, the dual staining and DAPI staining results demonstrated that the SnO2-SAPEG-Cro-NCs treatment effectively increased the apoptosis in the cervical cancer HeLa cells. Overall, the outcomes authorized that SnO2-SAPEG-Cro-NCs is an excellent antimicrobial and anticancer agent for future use. 2024 Elsevier B.V. Creator An entity primarily responsible for making the resource Chen H.; Govindasamy C.; Oh D.-H.; Chelliah R.; Ramamoorthy A.; Rengarajan T.; Hussein-Al-Ali S.H.; Chandrasekaran K.; Thangavelu I. Source A related resource from which the described resource is derived Journal of Drug Delivery Science and Technology, Vol-93 Publisher An entity responsible for making the resource available Editions de Sante Date A point or period of time associated with an event in the lifecycle of the resource 2024-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.jddst.2024.105449" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.jddst.2024.105449</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85183998690&amp;doi=10.1016%2Fj.jddst.2024.105449&amp;partnerID=40&amp;md5=9fe7ea12067177d5db9775d6682fae4a" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85183998690&amp;doi=10.1016%2fj.jddst.2024.105449&amp;partnerID=40&amp;md5=9fe7ea12067177d5db9775d6682fae4a</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 17732247; CODEN: JDDSA Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Chen H., Department of Gynaecology and Obstetrics, Tianjin Fifth Central Hospital, No. 41 Zhejiang Road, Tanggu Street, Binhai New Area, Tianjin, 300450, China; Govindasamy C., Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh, 11433, Saudi Arabia; Oh D.-H., Department of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kangwon National University, Chuncheon, 200-701, South Korea, Kangwon Institute of Inclusive Technology KIIT, Kangwon National University, Chuncheon, 24341, South Korea; Chelliah R., Department of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kangwon National University, Chuncheon, 200-701, South Korea, Kangwon Institute of Inclusive Technology KIIT, Kangwon National University, Chuncheon, 24341, South Korea, Saveetha School of Engineering, SIMATS, Tamil Nadu, Chennai, 600124, India; Ramamoorthy A., Department of Biochemistry, Sengamala Thayaar Educational Trust Women's College (Autonomous) (Affiliated to Bharathidasan University, Tiruchirappalli), Thiruvarur Dist., Tamil Nadu, Mannargudi, 614016, India; Rengarajan T., SCIGEN Research and Innovation Pvt. Ltd., Periyar Technology Business Incubator, Tamil Nadu, Thanjavur, 613403, India; Hussein-Al-Ali S.H., Department of Chemistry, Faculty of Sciences, Isra University, Amman, 11622, Jordan; Chandrasekaran K., Department Chemical and biochemical Engineering, Dongguk University, Seoul, 04620, South Korea; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India