Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Synthesis and characterization of 4-nitro benzaldehyde with ZnO-based nanoparticles for biomedical applications Subject The topic of the resource 4-nitrobenzaldehyde; antibacterial activity; anticancer; apoptosis; ZnO Description An account of the resource Globally, cancer is the leading cause of death and morbidity, and skin cancer is the most common cancer diagnosis. Skin problems can be treated with nanoparticles (NPs), particularly with zinc oxide (ZnO) NPs, which have antioxidant, antibacterial, anti-inflammatory, and anticancer properties. An antibacterial activity of zinc oxide nanoparticles prepared in the presence of 4-nitrobenzaldehyde (4NB) was also tested in the present study. In addition, the influence of synthesized NPs on cell apoptosis, cell viability, mitochondrial membrane potential (MMP), endogenous reactive oxygen species (ROS) production, apoptosis, and cell adhesion was also examined. The synthesized 4-nitro benzaldehyde with ZnO (4NBZnO) NPs were confirmed via characterization techniques. 4NBZnO NPs showed superior antibacterial properties against the pathogens tested in antibacterial investigations. As a result of dose-based treatment with 4NBZnO NPs, cell viability, and MMP activity of melanoma cells (SK-MEL-3) cells were suppressed. A dose-dependent accumulation of ROS was observed in cells exposed to 4NBZnO NPs. As a result of exposure to 4NBZnO NPs in a dose-dependent manner, viable cells declined and apoptotic cells increased. This indicates that apoptotic cell death was higher. The cell adhesion test revealed that 4NBZnO NPs reduced cell adhesion and may promote apoptosis of cancer cells because of enhanced ROS levels. 2023 Wiley-VCH GmbH. Creator An entity primarily responsible for making the resource Indumathi T.; Kumaresan I.; Suriyaprakash J.; Alarfaj A.A.; Hirad A.H.; Jaganathan R.; Mathanmohun M. Source A related resource from which the described resource is derived Journal of Basic Microbiology, Vol-64, No. 2 Publisher An entity responsible for making the resource available John Wiley and Sons Inc Date A point or period of time associated with an event in the lifecycle of the resource 2024-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1002/jobm.202300494" target="_blank" rel="noreferrer noopener">https://doi.org/10.1002/jobm.202300494</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85181191065&amp;doi=10.1002%2Fjobm.202300494&amp;partnerID=40&amp;md5=df1241b7bfe3550cfce4ed2c4a134eb7" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85181191065&amp;doi=10.1002%2fjobm.202300494&amp;partnerID=40&amp;md5=df1241b7bfe3550cfce4ed2c4a134eb7</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 0233111X; PubMed ID: 37988661; CODEN: JBMIE Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Indumathi T., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bangalore, India; Kumaresan I., Acharya Institute of Allied Health Sciences, Karnataka, Bangalore, India; Suriyaprakash J., Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou, China; Alarfaj A.A., Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia; Hirad A.H., Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia; Jaganathan R., Microbiology Unit, Preclinical Department, Faculty of Medicine, Universiti Kuala Lumpur, Royal College of Medicine Perak (UniKL-RCMP), Ipoh, Malaysia; Mathanmohun M., Department of Microbiology, Muthayammal College of Arts and Science, Rasipuram, Tamilnadu, Namakkal, India