Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Fluorescent imidazole derived sensor for selective in vitro and in vivo Fe2+ detection and bioimaging in zebrafish with DFT studies Subject The topic of the resource Bio-imaging; Coumarin; Cytotoxicity; Fe<sup>2+</sup>sensor; Imidazole; Zebrafish Description An account of the resource Herein, we have developed imidazole derivatized fluorescent probes IM-1 and IM-2 for extremely selective detection of Fe2+ with rapid response (LOD: 3.245 ?M for IM-1 and 0.297 ?M for IM-2) and excellent binding constants (0.214 105 M?1 and 1.004 105 M?1). Aqueous ethanol system was employed to assess the sensing potency of the probes both in vitro and in vivo in zebrafish is the main highlight of this work. The synthesized fluorophores possess admirable quantum yields of 0.61 and 0.78. The 1:1 binding mechanism of ligands with Fe2+ ions is supported by Job's plot and ESI-Mass spectrum. The synthesized probes demonstrated limited cytotoxicity both in vitro (MDA-MB-231 cells) and in vivo (zebrafish, Danio Rerio) studies. These results prompted us to employ the probes IM-1 and IM-2 to trace out intra cellular Fe2+ ions in zebrafish embryos. 2024 Elsevier B.V. Creator An entity primarily responsible for making the resource Nesaragi A.R.; Ahmed J.; Alsaiari M.; Naik L.; Kalagatur N.K.; Chandan H.R.; Hoolageri S.R.; Harraz F.A.; Balakrishna R.G.; Patil S.A. Source A related resource from which the described resource is derived Optical Materials, Vol-148 Publisher An entity responsible for making the resource available Elsevier B.V. Date A point or period of time associated with an event in the lifecycle of the resource 2024-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1016/j.optmat.2024.114850" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.optmat.2024.114850</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85182504904&doi=10.1016%2Fj.optmat.2024.114850&partnerID=40&md5=4829a33482739c78b8e59cc2a313cd23" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85182504904&doi=10.1016%2fj.optmat.2024.114850&partnerID=40&md5=4829a33482739c78b8e59cc2a313cd23</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 9253467; CODEN: OMATE Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Nesaragi A.R., Centre for Nano and Material Sciences, Jain (Deemed-to-be University), Jain Global Campus, Kanakapura, Karnataka, Bangalore, 562112, India; Ahmed J., Promising Centre for Sensors and Electronic Devices (PCSED), Advanced Materials and Nano-Research Centre, Najran University, Najran, 11001, Saudi Arabia, Department of Chemistry, Faculty of Science and Arts, Najran University, Najran, 11001, Saudi Arabia; Alsaiari M., Promising Centre for Sensors and Electronic Devices (PCSED), Advanced Materials and Nano-Research Centre, Najran University, Najran, 11001, Saudi Arabia, Department of Chemistry, Faculty of Science and Arts at Sharurah, Najran University, Sharurah, 68342, Saudi Arabia; Naik L., Department of Physics and Electronics, CHRIST (Deemed-to-be University), Bangalore Central Campus, Karnataka, Bengaluru, 560029, India; Kalagatur N.K., DRDO-BU, Centre for Life Sciences, Tamil Nadu, Coimbatore, 641 046, India; Chandan H.R., Centre for Nano and Material Sciences, Jain (Deemed-to-be University), Jain Global Campus, Kanakapura, Karnataka, Bangalore, 562112, India; Hoolageri S.R., Department of Studies in Chemistry, Karnatak University, Karnataka, Dharwad, 580003, India; Harraz F.A., Promising Centre for Sensors and Electronic Devices (PCSED), Advanced Materials and Nano-Research Centre, Najran University, Najran, 11001, Saudi Arabia, Department of Chemistry, Faculty of Science and Arts at Sharurah, Najran University, Sharurah, 68342, Saudi Arabia; Balakrishna R.G., Centre for Nano and Material Sciences, Jain (Deemed-to-be University), Jain Global Campus, Kanakapura, Karnataka, Bangalore, 562112, India; Patil S.A., Centre for Nano and Material Sciences, Jain (Deemed-to-be University), Jain Global Campus, Kanakapura, Karnataka, Bangalore, 562112, India