Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Synergistic effects of CuO/TiO2-chitosan-farnesol nanocomposites: Synthesis, characterization, antimicrobial, and anticancer activities on melanoma cells SK-MEL-3 Subject The topic of the resource anticancer; farnesol; mitochondrial membrane potential; nanocomposites; ROS; skin cancer Description An account of the resource The current investigation focuses on synthesizing copper oxide (CuO)-titanium oxide (TiO2)-chitosan-farnesol nanocomposites with potential antibacterial, antifungal, and anticancer properties against Melanoma cells (melanoma cells [SK-MEL-3]). The nanocomposites were synthesized using the standard acetic acid method and subsequently characterized using an X-ray diffractometer, scanning electron microscope, transmission electron microscopy, and Fourier transform infrared spectroscopy. The results from the antibacterial tests against Streptococcus pneumoniae and Stapylococcus aureus demonstrated significant antibacterial efficacy. Additionally, the antifungal studies using Candida albicans through the agar diffusion method displayed a considerable antifungal effect. For evaluating the anticancer activity, various assays such as MTT assay, acridine orange/ethidium bromide dual staining assay, reactive oxygen species (ROS) generation assay, and mitochondrial membrane potential (MMP) analysis were conducted on SK-MEL-3 cells. The nanocomposites exhibited the ability to induce ROS generation, decrease MMP levels, and trigger apoptosis in SK-MEL-3 cells. Collectively, the findings demonstrated a distinct pattern for the synthesized bimetallic nanocomposites. Furthermore, these nanocomposites also displayed significant (p &lt; 0.05) antibacterial, antifungal, and anticancer effects when tested on the SK-MEL-3 cell line. 2023 Wiley-VCH GmbH. Creator An entity primarily responsible for making the resource Indumathi T.; Suriyaprakash J.; Alarfaj A.A.; Hirad A.H.; Jaganathan R.; Mathanmohun M. Source A related resource from which the described resource is derived Journal of Basic Microbiology, Vol-64, No. 2 Publisher An entity responsible for making the resource available John Wiley and Sons Inc Date A point or period of time associated with an event in the lifecycle of the resource 2024-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1002/jobm.202300505" target="_blank" rel="noreferrer noopener">https://doi.org/10.1002/jobm.202300505</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85177439365&amp;doi=10.1002%2Fjobm.202300505&amp;partnerID=40&amp;md5=72ab3adda5e797a9390d61d32f850ce1" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85177439365&amp;doi=10.1002%2fjobm.202300505&amp;partnerID=40&amp;md5=72ab3adda5e797a9390d61d32f850ce1</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 0233111X; PubMed ID: 37988658; CODEN: JBMIE Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Indumathi T., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bangalore, India; Suriyaprakash J., Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou, China; Alarfaj A.A., Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia; Hirad A.H., Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia; Jaganathan R., Microbiology Unit, Preclinical Department, Faculty of Medicine, Royal College of Medicine Perak (UniKL-RCMP), Universiti Kuala Lumpur, Ipoh, Malaysia; Mathanmohun M., Department of Microbiology, Muthayammal College of Arts and Science, Rasipuram, Tamil Nadu, Namakkal, India