Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Self-assembled free nanocarrier prodrugs based on camptothecin and dihydroartemisinin exhibit accumulation and improved anticancer efficacy Subject The topic of the resource apoptosis; camptothecin; carrier-free; combination therapy; dihydroartemisinin; self-assemble Description An account of the resource Small molecule targeted inhibitor therapies often have several drawbacks, including limited oral bioavailability, quick metabolism, toxic effects that limit dosage, and poor water solubility. This study aims to develop a nanodrug self-delivery system that does not require a carrier by utilizing the self-assembly of camptothecin (CPT) and dihydroartemisinin (DHA). CPT/DHA nanoparticles (NPs) with varying diameters can be synthesized without requiring further carrier materials or chemical modifications by changing the CPT-to-DHA ratio (10:1, 5:1, 2:1, 1:1). Even more crucially, CPT/DHA NPs generate an AIE impact when they self-assemble. CPT/DHA NPs are used for cell tracking and bioimaging fluorescent probes. We chose CPT/DHA NPs (2:1) with a size of approximately 140nm for the anticancer examinations. The A549 cells were used to assess the cytotoxicity, morphological changes by biochemical staining methods and apoptosis by flow cytometric techniques of CPT/DHA NPs. Finally, in vitro anticancer research proved that CPT/DHA NPs are biocompatible and have strong synergistic anticancer properties. 2024 International Union of Biochemistry and Molecular Biology, Inc. Creator An entity primarily responsible for making the resource Garg M.; Rangaswamy R.; Mishra R.; Giri S.; Chinnathambi A.; Alahmadi T.A.; Arulselvan P.; Thangavelu I. Source A related resource from which the described resource is derived Biotechnology and Applied Biochemistry Publisher An entity responsible for making the resource available John Wiley and Sons Inc Date A point or period of time associated with an event in the lifecycle of the resource 2024-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1002/bab.2698" target="_blank" rel="noreferrer noopener">https://doi.org/10.1002/bab.2698</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85211098740&amp;doi=10.1002%2Fbab.2698&amp;partnerID=40&amp;md5=b2eaac74e7708ffb0d53eafc1ce88ce3" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85211098740&amp;doi=10.1002%2fbab.2698&amp;partnerID=40&amp;md5=b2eaac74e7708ffb0d53eafc1ce88ce3</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 8854513; CODEN: BABIE Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Garg M., Chitkara Centre for Research and Development, Chitkara University, Himachal Pradesh, Baddi, India; Rangaswamy R., Department of Chemistry and Biochemistry, JAIN (Deemed-to-be University), Karnataka, Bangalore, India; Mishra R., Centre of Research Impact and Outcome, Chitkara University, Punjab, Rajpura, India; Giri S., Department of Sciences, Vivekananda Global University, Rajasthan, Jaipur, India; Chinnathambi A., Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia; Alahmadi T.A., Department of Pediatrics, College of Medicine and King Khalid University Hospital, King Saud University, Medical City, Riyadh, Saudi Arabia; Arulselvan P., Department of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Tamil Nadu, Chennai, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bangalore, India