Normalized group activations based feature extraction technique using heterogeneous data for Alzheimers disease classification
- Title
- Normalized group activations based feature extraction technique using heterogeneous data for Alzheimers disease classification
- Creator
- Vaithianathan K.; Pernabas J.B.; Parthiban L.; Rashid M.; Alshamrani S.S.
- Description
- Several deep learning networks are developed to identify the complex atrophic patterns of Alzheimers disease (AD). Among various activation functions used in deep neural networks, the rectifier linear unit is the most used one. Even though these functions are analyzed individually, group activations and their interpretations are still not explored for neuroimaging analysis. In this study, a unique feature extraction technique based on normalized group activations that can be applied to both structural MRI and resting-state-fMRI (rs-fMRI) is proposed. This method is split into two phases: multi-trait condensed feature extraction networks and regional association networks. The initial phase involves extracting features from various brain regions using different multi-layered convolutional networks. Then, multiple regional association networks with normalized group activations for all the regional pairs are trained and the output of these networks is given as input to a classifier. To provide an unbiased estimate, an automated diagnosis system equipped with the proposed feature extraction is designed and analyzed on multi-cohort Alzheimers Disease Neuroimaging Initiative (ADNI) data to predict multi-stages of AD. This system is also trained/tested on heterogeneous features such as non-transformed features, curvelets, wavelets, shearlets, textures, and scattering operators. Baseline scans of 185 rs-fMRIs and 1442 MRIs from ADNI-1, ADNI-2, and ADNI-GO datasets are used for validation. For MCI (mild cognitive impairment) classifications, there is an increase of 14% in performance. The outcome demonstrates the good discriminatory behaviour of the proposed features and its efficiency on rs-fMRI time-series and MRI data to classify multiple stages of AD. 2024 Vaithianathan et al.
- Source
- PeerJ Computer Science, Vol-10, pp. 1-30.
- Date
- 2024-01-01
- Publisher
- PeerJ Inc.
- Subject
- Alzheimers disease; Classification; Deep learning; Feature extraction; Functional connectivity; Normalized group activations
- Coverage
- Vaithianathan K., Department of Computer Engineering, Karaikal Polytechnic College, Karaikal, Puducherry, Varichikudy, India; Pernabas J.B., Department of Computer Science and Engineering, CHRIST (Deemed to be University, Kengeri Campus, Karnataka, India; Parthiban L., Department of Computer Science and Engineering, Community College, Pondicherry University, Puducherry, India; Rashid M., School of Information Communication and Technology, Bahrain Polytechnic, Isa Town, Bahrain; Alshamrani S.S., Department of Information Technology, College of Computers and Information Technology, Taif University, Taif, Saudi Arabia
- Rights
- All Open Access; Gold Open Access
- Relation
- ISSN: 23765992
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Vaithianathan K.; Pernabas J.B.; Parthiban L.; Rashid M.; Alshamrani S.S., “Normalized group activations based feature extraction technique using heterogeneous data for Alzheimers disease classification,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 23, 2025, https://archives.christuniversity.in/items/show/13424.