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Title A name given to the resource Multifunctional SnO?-Chitosan-D-carvone Nanocomposite: A Promising Antimicrobial, Anticancer, and Antioxidant Agent for Biomedical Applications Subject The topic of the resource Anticancer Activity; Antimicrobial Activity; Antioxidant Activity; MOLT-4 Cells; SnO2; SnO2-Cs-Dcar Nanocomposites Description An account of the resource Nanocomposite made up of inorganic and biocompatible polymer have gained significant attention for biomedical applications due to their enhanced multifunctional properties, offering solutions to serious issues like antimicrobial resistance and cancer treatment. Nanocomposite composed of SnO?, chitosan and D-carvone (SnO2-Cs-Dcar) was prepared to ascertain its efficacy in application for antimicrobial, anticancer activities, and antioxidant effects. The synthesized nanocomposite was characterized by XRD, UV-Vis, FTIR, PL, SEM, TEM, and XPS techniques, confirming successful integration. XRD results confirmed the tetragonal rutile phase of SnO2. The band gap energy was calculated as 4.32eV for SnO2 nanoparticles and 3.11eV for SnO2-Cs-Dcar nanocomposite as observed from UV-Visible spectra. PL emission results showed that SnO2-Cs-Dcar nanocomposite exhibited green emission at 507nm corresponds to number oxygen vacancy site. SEM and TEM results showed that the SnO2-Cs-Dcar nanocomposite entities appear more compact, and the single SnO2 particles are less differentiated, possibly because they have been covered by chitosan and D-carvone. Antimicrobial activity against the pathogens Klebsiella pneumoniae, Candida albicans, Shigella dysenteriae, Bacillus subtilis, and Staphylococcus aureus demonstrated that SnO2-Cs-Dcar exhibited enhanced bacteriostatic effect when compared to bare SnO2. MTT assay on MOLT-4 cancer cells revealed that SnO2-Cs-Dcar nanocomposite exhibited enhanced anticancer activity upon compared to SnO? nanoparticles. The IC50 values were calculated as 13.6 for SnO2 and 12.1 for SnO2-Cs-Dcar nanocomposite. SnO?-Cs-Dcar nanocomposites exhibits high antioxidant activity evidenced by improved free radical scavenging action in comparison with a bare SnO?. Experimental result indicates that the SnO?-Cs-Dcar nanocomposites can be used as biocidal agent for antimicrobial and anticancer therapies. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Creator An entity primarily responsible for making the resource Bamagous G.A.; Ibrahim I.A.A.; Alzahrani A.R.; Shahid I.; Shahzad N.; Falemban A.H.; Alanazi I.M.M.; Hussein-Al-Ali S.H.; Arulselvan P.; Thangavelu I. Source A related resource from which the described resource is derived Journal of Inorganic and Organometallic Polymers and Materials Publisher An entity responsible for making the resource available Springer Date A point or period of time associated with an event in the lifecycle of the resource 2024-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1007/s10904-024-03447-z" target="_blank" rel="noreferrer noopener">https://doi.org/10.1007/s10904-024-03447-z</a> <a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85208107719&doi=10.1007%2Fs10904-024-03447-z&partnerID=40&md5=7149fbe5119061ab02aa80714481938c" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85208107719&doi=10.1007%2fs10904-024-03447-z&partnerID=40&md5=7149fbe5119061ab02aa80714481938c</a> Rights Information about rights held in and over the resource Restricted Access Relation A related resource ISSN: 15741443 Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Bamagous G.A., Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, P.O.Box 13578, Al-Abidiyah, Makkah, 21955, Saudi Arabia; Ibrahim I.A.A., Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, P.O.Box 13578, Al-Abidiyah, Makkah, 21955, Saudi Arabia; Alzahrani A.R., Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, P.O.Box 13578, Al-Abidiyah, Makkah, 21955, Saudi Arabia; Shahid I., Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, P.O.Box 13578, Al-Abidiyah, Makkah, 21955, Saudi Arabia; Shahzad N., Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, P.O.Box 13578, Al-Abidiyah, Makkah, 21955, Saudi Arabia; Falemban A.H., Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, P.O.Box 13578, Al-Abidiyah, Makkah, 21955, Saudi Arabia; Alanazi I.M.M., Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, P.O.Box 13578, Al-Abidiyah, Makkah, 21955, Saudi Arabia; Hussein-Al-Ali S.H., Department of Chemistry, Faculty of Sciences, Isra University, Amman, 11622, Jordan; Arulselvan P., Department of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, 602105, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bangalore, 560029, India