Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Articles Article Faculty Publications -Articles Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Histopathological and Toxicological Studies on Zebra Fish Using White-Fruited and Green-Fruited Varieties of Momordica charantia Description An account of the resource Momordica charantia is well known for its medicinal properties. It has exhibited various pharmacological activities, such as antidiabetic, anti-inflammatory, and antimicrobial activities. Although this plant is used worldwide as a vegetable and medicinal ingredient in herbal medicines, its toxicity studies have not been conducted to date. This study attempts to understand its toxicity. The present study examined the activity of two enzymes, acetylcholinesterase and succinate dehydrogenase, as well as histopathological variations in the liver, intestine, and gills of zebrafish. The results of the acetylcholinesterase assay showed that the concentrations of 40 mg/L and 60 mg/L of the four extracts (leaf and fruit extracts of both varieties) exhibited increased enzyme activity. Interestingly, the leaves of the green fruit variety at a concentration of 60 mg/L showed the highest activity, with a value of 2.824 0.0682 micromoles/min compared to the control value of 1.8347 0.0046 micromoles/min. On the other hand, the succinate dehydrogenase assay revealed that the concentrations of 40 mg/L and 60 mg/L of the extracts decreased the enzyme activity. The highest inhibition was observed in the concentration of 60 mg/L of the leaves of the white-fruited variety and the green-fruited variety, with values of 1.884 0.0482 micromoles/min compared to the control value of 2.747 0.0046 micromoles/min. The studies on histopathological changes also demonstrated abnormalities in the brain, liver, intestine, and gills of zebrafish after the exposure to the extracts of M. charantia. The severity of the damage varied from low to high concentraions. In general, this study sheds light on the safety profile of Momordica charantia and highlights its potential toxicity in animal models. The findings suggest that more research is needed to fully understand the toxicity of this plant and its implications for human use. 2024 Jobi Xavier et al. Creator An entity primarily responsible for making the resource Xavier J.; Jose J.; Reddy J.; Ka P. Source A related resource from which the described resource is derived Scientifica, Vol-2024 Publisher An entity responsible for making the resource available Hindawi Limited Date A point or period of time associated with an event in the lifecycle of the resource 2024-01-01 Identifier An unambiguous reference to the resource within a given context <a href="https://doi.org/10.1155/2024/4689625" target="_blank" rel="noreferrer noopener">https://doi.org/10.1155/2024/4689625</a> <br /><br /><a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85197219738&amp;doi=10.1155%2F2024%2F4689625&amp;partnerID=40&amp;md5=49390b9c448e8d9dfecbf2c5ceba05cc" target="_blank" rel="noreferrer noopener">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85197219738&amp;doi=10.1155%2f2024%2f4689625&amp;partnerID=40&amp;md5=49390b9c448e8d9dfecbf2c5ceba05cc</a> Rights Information about rights held in and over the resource All Open Access; Gold Open Access; Green Open Access Relation A related resource ISSN: 2090908X Format The file format, physical medium, or dimensions of the resource Online Language A language of the resource English Type The nature or genre of the resource Article Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Xavier J., Department of Life Sciences, Christ University, Karnataka, Bangalore, India; Jose J., Department of Life Sciences, Christ University, Karnataka, Bangalore, India; Reddy J., Department of Botany, St. Joseph's University, Karnataka, Bengaluru, India; Ka P., Department of Life Sciences, Christ University, Karnataka, Bangalore, India