Elevating pyrrole derivative synthesis: a three-component revolution

Title

Elevating pyrrole derivative synthesis: a three-component revolution

Creator

Kumar S L.; Servesh A.; Chundattu S.J.; Tabassum S.; Govindaraju S.

Description

Pyrrole is an essential chemical with considerable relevance as a pharmaceutical framework for many biologically necessary medications. The growing demand for biologically active compounds calls for a simple one-pot method for generating novel pyrrole derivatives. Nots surprisingly, several multicomponent reactions (MCRs) aim to synthesize pyrrole derivatives. However, this review presents the three-component synthesis of pyrrole derivatives, highlighting the significance of multicomponent reaction in synthesizing eclectic multi-functionalised pyrrole covering the selected literature on the three-component synthesis of substituted pyrrole from 2016 to late 2023. Furthermore, this article classifies the reactions based on the starting material with functional groups involved in the pyrrole ring formation. Graphical Abstract: (Figure presented.) The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024.

Source

Molecular Diversity

Date

2024-01-01

Publisher

Springer Nature

Subject

Multicomponent; One-pot; Pyrrole; Review; Three-component

Coverage

Kumar S L., Department of Chemistry, CHRIST - Deemed to Be University, Karnataka, Bengaluru, 560029, India; Servesh A., Department of Chemistry, CHRIST - Deemed to Be University, Karnataka, Bengaluru, 560029, India; Chundattu S.J., Department of Sciences & amp; Humanities, CHRIST - Deemed to Be University, Karnataka, Bengaluru, 560074, India; Tabassum S., Department of Chemistry, Surana College, Karnataka, Bengaluru, 560074, India; Govindaraju S., Department of Sciences & amp; Humanities, CHRIST - Deemed to Be University, Karnataka, Bengaluru, 560074, India

Rights

Restricted Access

Relation

ISSN: 13811991; CODEN: MODIF

Format

Online

Language

English

Type

Article

Identifier

https://doi.org/10.1007/s11030-024-10884-y

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85193713762&doi=10.1007%2fs11030-024-10884-y&partnerID=40&md5=f28189106521b1d279b75058d63fb21c