Photophysical and antitubercular studies on newly synthesised structurally architectured sulphonamide
- Title
- Photophysical and antitubercular studies on newly synthesised structurally architectured sulphonamide
- Creator
- Shekharagouda P.; Mamatha G.P.; Nagaraju G.; Krishnamurthy C.; Sajjan V.P.; Ali Al-Asbahi B.; Mohammed Al-Hada N.; Gowda B.G.; Naik L.
- Description
- This study presents the synthesis and characterisation of four mono-azo sulphonamide derivatives through diazo-coupling electrophilic substitution reactions. The structural analysis of the synthesised molecules was conducted utilising FT-IR, 1H-NMR and HR-MS techniques. Absorption and fluorescence maxima of the synthesised molecules were determined across solvents of varying polarity to explore Solvatochromic behaviour. Density functional theory was employed to elucidate electronic and optical properties, including the computation of HOMOLUMO energies using Gaussian 09W software, with comparisons to experimental data. Molecular electrostatic potential 3D plots identified electrophilic and nucleophilic sites. Solvent interactions were evaluated using KamletAbboud Taft and Catalan parameters. Further, global chemical reactivity descriptors were estimated to ascertain chemical reactivity of the molecules. Additionally, the effectiveness of the colourant anti-tubercular activity was evaluated using in vitro and molecular docking techniques. The biological activity results reveal that methyl-pyridone and barbituric acid coupled with sulphamethizole (SMP and SMB) displayed excellent anti-tubercular activity compared with the standard Gentamycin. 2024 Informa UK Limited, trading as Taylor & Francis Group.
- Source
- Molecular Physics
- Date
- 2024-01-01
- Publisher
- Taylor and Francis Ltd.
- Subject
- Antitubercular potency; azo dye; chemical reactivity parameters; DFT studies; MESP
- Coverage
- Shekharagouda P., Department of Studies in Chemistry, Davangere University, Davanagere, India; Mamatha G.P., Department of Studies in Chemistry, Davangere University, Davanagere, India; Nagaraju G., Energy Material Research Laboratory, Department of Chemistry, Siddaganga Institute of Technology, Tumakuru, India; Krishnamurthy C., Department of PG Studies and Research in Chemistry, Kuvempu University, Shivamogga, India; Sajjan V.P., Department of Chemistry, Rani Channamma University, Belagavi, India; Ali Al-Asbahi B., Department of Physics & Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia; Mohammed Al-Hada N., Shandong Key Laboratory of Biophysics, Institute of Biophysics, Dezhou University, Dezhou, China; Gowda B.G., Department of Chemistry, Maharani Cluster University, Bangalore, India; Naik L., Department of Physics and Electronics, CHRIST University, Bengaluru, Bengaluru, India
- Rights
- Restricted Access
- Relation
- ISSN: 268976; CODEN: MOPHA
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Shekharagouda P.; Mamatha G.P.; Nagaraju G.; Krishnamurthy C.; Sajjan V.P.; Ali Al-Asbahi B.; Mohammed Al-Hada N.; Gowda B.G.; Naik L., “Photophysical and antitubercular studies on newly synthesised structurally architectured sulphonamide,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 25, 2025, https://archives.christuniversity.in/items/show/13636.